KM Engle

Publications (2)0 Total impact

• Article: Hydroxyl-directed C-H carbonylation enabled by mono-N-protected amino acid ligands: An expedient route to 1-isochromanones

  Y Lu, DS Leow, XS Wang, KM Engle, JQ Yu
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  ABSTRACT: Cited References Count:61|ROYAL SOC CHEMISTRY|THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND|ISI Document Delivery No.:764KY
  Chemical Science. 01/2011; 2:967-971.
• Article: Hydroxyl-directed C-H carbonylation enabled by mono-N-protected amino acid ligands: An expedient route to 1-isochromanones

  Y Lu, DS Leow, XS Wang, KM Engle, JQ Yu
  [show abstract] [hide abstract]
  ABSTRACT: A Pd(II)-catalyzed C-H carbonylation protocol of phenethyl alcohols has been developed using amino acid ligands to promote the reaction. This transformation provides an expedient route to 1-isochromanone motifs, which are common structural elements in natural products and other biologically active compounds. A concise synthesis of a histamine release inhibitor showcases the utility of this transformation.
  Chemical Science. 01/2011; 2(5):967-971.