Jing Li

Shenyang Pharmaceutical University, Feng-t’ien, Liaoning, China

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Publications (843)2466.03 Total impact

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    ABSTRACT: Bacillus subtilis strain GB03 has been shown to confer salt tolerance in Arabidopsis thaliana. In this study, the potential for GB03 to promote biomass accumulation and increase salt tolerance was investigated in wheat (Triticum aestivum). Soil-grown wheat seedlings were assayed for dry-weight increase. Endogenous Na+ and K+ contents were determined in plants with or without soil inoculation with GB03 along with 0, 25 or 100mM NaCl solution added to the 5 soil. We demonstrated that the introduction of GB03 in the soil triggered wheat biomass accumulation. Furthermore, GB03 improved salt tolerance as measured by increased tissue mass, lower Na+ accumulation and improved K+/Na+ ratio when GB03-inoculated plants were grown under elevated salt conditions. This study provides insight for the application of selected bacteria to monocot crops to combat saline toxicity.
    Crop and Pasture Science 10/2014; 65(5):423-427. · 1.13 Impact Factor
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    ABSTRACT: Investigation on diversity of culturable fungi mainly focused on sponges and corals, yet little attention had been paid to the fungal communities associated with zoanthid corals. In this study, a total of 193 culturable fungal strains were isolated from the zoanthid Palythoa haddoni collected in the South China Sea, of which 49 independent isolates were identified using both morphological characteristics and internal transcribed spacer (ITS) sequence analyses. Thirty-five strains were selected for phylogenetic analysis based on fungal ITS sequences. The results indicated that 18 genera within eight taxonomic orders of two phyla (seven orders of the phylum Ascomycota and one order of the phylum Basidiomycota) together with one unidentified fungal strain have been achieved, and Cladosporium sp. represented the dominant culturable genus. Particularly, 14 genera were isolated from a zoanthid for the first time. The antibacterial activities of organic extracts of mycelia and fermentation broth of 49 identified fungi were evaluated, and 29 (59.2 %) of the isolates displayed broad-spectrum or selective antibacterial activity. More interestingly, more than 60 % of the active fungal strains showed strong activity against two aquatic pathogenic bacteria Nocardia brasiliensis and Vibrio parahaemolyticus, compared with other pathogenic bacteria, indicating that zoanthid-derived fungi may protect its host against pathogens. This is the first report of systematically phylogenetic diversity and extensively antibacterial activity of zoanthid-derived fungi.
    Marine biotechnology (New York, N.Y.). 08/2014;
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    ABSTRACT: The stress protein heme oxygenase-1 (HO-1) is upregulated and co-localizes to pathological features, including tauopathies in the brains of individuals with Alzheimer's disease. However, the relationship between HO-1 and Alzheimer's disease remains unclear. In our previous research, the long-term overexpression of HO-1 was shown to promote tau aggregation by inducing tau phosphorylation in the mouse brain. In this study, we found that the long-term overexpression of HO-1 led to cognitive decline in transgenic mice, as determined by the water maze test, and that HO-1 can affect two pathways for tauopathy. Through one pathway, HO-1 promotes the expression of CDK5 by accumulating reactive oxygen species, which are produced by HO-1 downstream products of iron in neuro2a cell lines and mouse brain. Through the second pathway, HO-1 induces tau truncation at D421 in vivo and in vitro. Clearly, there is a HO-1-dependent mechanism responsible for tau protein phosphorylation and tau truncation in vivo and in vitro. Taken together, our results suggest that HO-1 plays an important role in the disease process of tauopathies in AD.
    Journal of Alzheimer's disease: JAD 08/2014; · 4.17 Impact Factor
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    ABSTRACT: Seven new prenylated indole diketopiperazines, versicamides A-G (1-7) and a novel chemical derivative from 7, versicamide H (8), along with three known analogic diketopiperazines (9-11) were obtained from the marine-derived fungus Aspergillus versicolor HDN08-60. Their structures were determined by spectroscopic techniques including 2D NMR, ECD calculations, and single-crystal X-ray diffraction analysis, together with the assistance of further chemical conversions. The cytotoxicities of 1-8 were tested on Hela, HCT-116, HL-60 and K562 cell lines, though only 8 exhibited moderate activity against HL-60 cells with IC50 values of 8.7 μM. Further investigation with target screening showed that 8 exhibited selective PTK inhibitory activities.
    The Journal of organic chemistry. 08/2014;
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    ABSTRACT: Growing evidence indicates that miR-200c is involved in carcinogenesis and tumor progression in non-small-cell lung cancer (NSCLC). However, its precise biological role remains largely elusive.
    Molecular cancer. 07/2014; 13(1):166.
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    ABSTRACT: BackgroundAKT1 is an important downstream effector of PTEN/PI3K/AKT signal transduction pathway. Aberrant expression and genetic variant of AKT1 gene are suggested to be involved in several types of human cancers, including OSCC. The aim of this study was to investigate the possible association between AKT1 gene polymorphisms and OSCC in Chinese Han Population.MethodsA total of 182 OSCC patients and 207 cancer-free controls were enrolled for this hospital-based study. Five single-nucleotide polymorphisms (SNPs) on AKT1 (rs1130214, rs1130233, rs2494732, rs3730358, rs3803300) were investigated and genotyped by Sequenom Mass ARRAY & iPLEX-MALDI-TOF technology. Chi-square test, SHEsis software, and Kaplan–Meier method were used to evaluate the relationship between selected SNPs and OSCC susceptibility and progression.ResultsSignificant difference of genotype distribution was observed between cases and control group at SNP sites rs1130214 (P = 0.006) and rs3803300 (P = 0.033, P = 0.003 for heterozygote and homozygous mutant, respectively). In the haplotype analysis, haplotype H4 which contained mutant-type allele of rs1130214 and rs3803300 was also related to OSCC risk (OR = 1.974, 95% CI = 1.048–3.718). Moreover, CT genotype of rs3730358 was associated with higher risk of OSCC progression (HR = 2.466, 95% CI = 1.017–5.981).Conclusion Our results indicated that rs1130214 and rs3803300 were related to OSCC susceptibility in Chinese Han Population. In addition, rs3730358 might be associated with progression-free survival time of OSCC patients, suggesting that this SNP could be a potential prognosis marker for OSCC.
    Journal of Oral Pathology and Medicine 07/2014; · 2.06 Impact Factor
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    ABSTRACT: In this study, we provide the first comprehensive annotation of canine interferon-λ (CaIFN-λ, type III IFN). Phylogenetic analysis based on genomic sequences indicated that CaIFN-λ is located in the same branch with Swine IFN-λ1 (SwIFN-λ), Bat IFN-λ1 (BaIFN-λ), and human IFN-λ1 (HuIFN-λ1). CaIFN-λ was cloned, expressed in Escherichia coli, and purified to further investigate the biological activity in vitro. The recombinant CaIFN-λ (rCaIFN-λ) displayed potent antiviral activity on both homologous and heterologous animal cells in terms of inhibiting the replication of the New Jersey serotype of vesicular stomatitis virus (VSV), canine parvovirus, and influenza virus A/WSN/33 (H1N1), respectively. In addition, we also found that rCaIFN-λ exhibits a significant antiproliferative response against A72 canine tumor cells and MDCK cells in a dose-dependent manner. Furthermore, CaIFN-λ activated the JAK-STAT signaling pathway. To evaluate the expression of CaIFN-λ induced by virus and the expression of IFN-stimulated genes (ISGs) induced by rCaIFN-λ in the MDCK cells, we measured the relative mRNA level of CaIFN-λ and ISGs (ISG15, Mx1, and 2'5'-OAS) by quantitative real-time PCR and found that the mRNA level of CaIFN-λ and the ISGs significantly increased after treating the MDCK cells with viruses and rCaIFN-λ protein, respectively. Finally, to evaluate the binding activity of rCaIFN-λ to its receptor, we expressed the extracellular domain of the canine IFN-λ receptor 1 (CaIFN-λR1-EC) and determined the binding activity via ELISA. Our results demonstrated that rCaIFN-λ bound tightly to recombinant CaIFN-λR1-EC (rCaIFN-λR1-EC).
    06/2014;
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    ABSTRACT: The organic palladium complex Pd(H2bpydc)Cl2 (H2bpydc = 2,2′-bipyridine-5,5′-dicarboxylic acid) was immobilized on a porous metal–organic framework UiO-67 (Zr6O4(OH)4(bpdc)6, bpdc = para-biphenyldicarboxylate) using a direct incorporation strategy. The use of a large amount of the H2bpdc ligand (90 mol% of the mixed ligands) that can't chelate the Pd complex allowed the formation of isolated Pd single active sites uniformly distributed in the MOF network. Pd(II) doped UiO-67 is isostructural to the parent UiO-67 framework, with a high surface area and pore volume of ca. 2000 m2 g−1 and 0.79 cm3 g−1, respectively. The material was highly efficient in the catalytic conversion of aryl chlorides, showing remarkably higher activity than the homogeneous Pd counterparts. High yields were achieved in Heck and Suzuki–Miyaura coupling reactions of chloroarenes bearing a wide range of substituents. Moreover, the catalyst was recoverable and reusable, giving essentially identical activity after at least 5 cycles. The combination of the advantages of both homogeneous molecular Pd catalysts and solid MOF structures in this system may bring new opportunity in the development of highly active heterogeneous palladium catalysts for a variety of Pd-catalyzed transformations.
    Green Chemistry 05/2014; 16:3978–3985. · 6.83 Impact Factor
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    ABSTRACT: A computational study with the Becke3LYP DFT functional was carried out on the formation of iridacycles and rhodacycles through C–H activation of phenyl imines in methanol solvent. The whole catalytic pathway was proposed and verified, starting from the catalyst [Cp*MCl2]2 cleavage and ending with the cyclometalated complex. The five most important issues, namely, chloride dissociation and C–H activation precursor formation, aromatic C–H bond activation, the reaction rate difference between the Ir and Rh systems, the nature of regioselectivity, and the role of the protic solvent are discussed. The calculations indicate that the C–H bond activation by the transition metal iridium is kinetically and thermodynamically more favorable than that by rhodium, and the regioselectivity of the reaction has been determined both electronically and sterically.
    Organometallics 05/2014; 33(9):2150–2159. · 4.15 Impact Factor
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    ABSTRACT: The class 1 integron is an important driver of the nosocomial dissemination of multidrug-resistant (MDR) bacteria, such as Acinetobacters. In this study, we characterized the gene cassette arrays of class 1 integrons in Acinetobacter baumannii, where the detailed structure of these integrons for 38 clinical strains was analyzed. The results showed that there are three types of gene cassette arrays that are carried by different class 1 integrons, among them the aac(6')-IId-catB8-aadA1 array was the most prevalent. For detailed analysis of the integron structure, whole genome sequencing was carried out on strain AB16, and it was found that a single integron on its chromosome has a partial Tn21 transposon in its 5' flanking region and two complete copies of the insertion element IS26 in both the 5' and 3' flanking regions, indicating that the integron could be acquired by horizontal gene transfer. Furthermore, there is one resistance island AbaR22, one bla gene containing a transposon, four intrinsic resistant genes and one efflux pump that together confer six types of antibiotic resistance.
    Microbiological Research 04/2014; · 1.99 Impact Factor
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    ABSTRACT: Influenza B virus is an enveloped negative-strand RNA virus, that contributes considerably to annual influenza illnesses in human. The matrix protein of influenza B virus (BM1) acts as a cytoplasmic-nuclear shuttling protein during the early and late stages of infection. The mechanism of this intracellular transport of BM1 was revealed through the identification of two leucine-rich CRM1-dependent nuclear export signals (NESs) (3-14aa and 124-133aa), one bipartite nuclear localization signal (NLS) (76-94aa), and two phosphorylation sites (80T and 84S) in BM1. The biological function of the NLS and NES regions were determined through the observation of the intracellular distribution of EGFP-tagged signal peptides, and WT, NES-mutant and NLS-mutant EGFP-BM1. Furthermore, the NLS phosphorylation sites 80T and 84S, were found to be required for the nuclear accumulation of EGFP-NLS and for the efficient binding of EGFP-BM1 to human importin-α 1. Moreover, all of these regions/sites were required for the generation of viable influenza B virus in a 12-plasmid virus rescue system. This study expands our understanding of the life cycle of influenza B virus by defining defines/presents the dynamic mechanism of the nucleocytoplasmic shuttle of BM1, and could provide a scientific basis for the development of anti-viral medication.
    Journal of Virology 04/2014; · 5.08 Impact Factor
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    ABSTRACT: The influenza A virus nuclear export protein (NEP) plays crucial roles in the nuclear export of the viral ribonucleoprotein complex through the CRM1-mediated cellular protein transport system. However, the detailed mechanism of NEP nucleocytoplasmic trafficking remain incompletely understood. Here, we investigated the subcellular localization of NEP from two strains of H1N1 influenza A virus and found that 2009 swine-origin H1N1 influenza A virus A/California/04/2009 (CA04) NEP displayed a distinct cellular distribution pattern, forming unique nuclear aggregates, compared to A/WSN/33 (H1N1) (WSN) NEP. Characterization of the nucleocytoplasmic transport pathways of these two NEPs showed that they both enter the nucleus by passive diffusion but are exported through the nuclear export receptor chromosome region maintenance 1 (CRM1)-mediated pathway with different efficiencies. The two identified NESs on both NEPs functioned similarly despite differences in their amino acid sequences. Using a two-hybrid assay, we confirmed that the CA04 NEP interacts less efficiently with CRM1, and a threonine residue at position 48 is responsible for the nuclear aggregation. The present study revealed the dissimilarity in subcellular NEP transport processes between the 2009 pandemic (H1N1) influenza A virus CA04 and lab-adapted H1N1 virus WSN and uncovered the mechanism for this difference. Because the efficiency of the nucleocytoplasmic transport of viral components is often correlated with the viral RNA polymerase activity, propagation, and host range of influenza viruses, the present study investigated the subcellular localization of NEP from two strains of H1N1 influenza virus. We found that both the NEPs of A/California/04/2009 (H1N1) (CA04) and A/WSN/33 (H1N1) (WSN) enter the nucleus by passive diffusion but are exported with different efficiencies, which was caused by weaker binding activity between the CA04 NEP and CRM1. The results of the present study revealed characteristics of the nuclear import and export pathways of NEP and mechanism for the difference in cellular distribution of NEP between two H1N1 strains.
    Journal of Virology 04/2014; · 5.08 Impact Factor
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    ABSTRACT: To investigate the impact of heteroresistance on the results of genotype drug susceptibility test for Mycobacterium tuberculosis (M. tuberculosis).
    04/2014; 37(4):260-5.
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    ABSTRACT: The purpose of this study was to prepare and characterize nanoporous silica@poly(ethyleneimine) s (NS@P) xerogel and methanol modified NS@P xerogel synthesized with biomimetic method, and investigate controlled release behavior of propranolol hydrochloride (PNH) loaded carrier materials in vitro and in vivo. Preparation was conducted at ambient conditions, and NS@P xerogel as well as PNH loaded NS@P xerogel were characterized using fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and differential scanning calorimeter (DSC). Investigations on morphology and porous characteristics of NS@P xerogel and methanol modified NS@P xerogel were evaluated with scanning electron microscopy (SEM), transmission electron microscopy (TEM) and nitrogen adsorption. The results showed that the order of morphology compactness was NS@P xerogel>25%NS@P xerogel>75%NS@P xerogel because PEIs scaffold ability for silica condensation and forming hydrogen bond weakened with increasing volume ratio of methanol modification. Moreover, SBET decreased and uniformity of pore size distribution was interrupted after methanol modification. PNH loaded carrier materials displayed controlled release, and release effect was related with pore size of materials and PEIs scaffold ability. In vivo pharmacokinetic study demonstrated that release of PNH was delayed due to the PNH incorporated inside carrier materials and controlled release effect was in accordance with in vitro results.
    International Journal of Pharmaceutics 03/2014; · 3.99 Impact Factor
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    ABSTRACT: To identify cancer-related proteins, we used isobaric tags in a relative and absolute quantitation (iTRAQ) proteomic approach and SWATH™ quantification approach to analyze the secretome of an isogenic pair of highly metastatic and low metastatic non-small-cell lung cancer (NSCLC) cell lines. In addition, we compared two groups of pooled serum samples (12 early-stage and 12 late-stage patients) to mine data for candidates screen by iTRAQ-labeled proteomic analysis. A total of 110 proteins and 71 proteins were observed to be significantly differentially expressed in the cell line secretome and NSCLC sera, respectively. Among these proteins, CD109 was found to be highly expressed in both the highly metastatic cell line secretome and the group of late-stage patients. A sandwich ELISA assay also demonstrated an elevation of serum CD109 levels in individual NSCLC patients (n=30) compared with healthy subjects (n=19). Furthermore, CD109 displayed higher expression in lung cancer tissues compared with their matched noncancerous lung tissues (n=72). In addition, the knockdown of CD109 influenced several NSCLC cell bio-functions, for instance, depressing cell growth, affecting cell cycle phases. These phenomena suggest that CD109 plays a critical role in NSCLC progression. Biological Significance We simultaneously applied two quantitative proteomics approaches-iTRAQ-labeling and SWATH™-to analyze the secretome of metastatic cell lines, in order to explore the cancer-associated proteins in conditioned media. In this study, our results indicate that CD109 plays a critical role in non-small-cell lung cancer (NSCLC) progression, and is overexpressed in advanced NSCLC.
    Journal of proteomics 03/2014; · 5.07 Impact Factor
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    ABSTRACT: Macaques are the most widely distributed non-human primates and used as animal models in biomedical research. The availability of full-genome sequences from them would be essential to both biomedical and primate evolutionary studies. Previous studies have reported whole-genome sequences from rhesus macaque (Macaca mulatta) and cynomolgus macaque (M. fascicularis, CE), both of which belong to the fascicularis group. Here, we present a 37-fold coverage genome sequence of the Tibetan macaque (M. thibetana; TM). TM is an endemic species to China belonging to the sinica group. Based on mapping to the rhesus macaque genome, we identified approximately 11.9 million single nucleotide variants (SNVs), of which 3.9 million were TM specific, as assessed by comparison two Chinese rhesus macaques (CR) and two CE genomes. Some genes carried TM-specific homozygous non-synonymous variants (TSHNVs), which were scored as deleterious in human by both PolyPhen-2 and SIFT, and were enriched in the eye disease genes. In total, 273 immune response and disease related genes carried at least one TSHNV. The heterozygosity rates of two CRs (0.002617 and 0.002612) and two CEs (0.003004 and 0.003179) were approximately three times higher than that of TM (0.000898). PCR re-sequencing of 18 TM individuals showed that 29 TSHNVs exhibited high allele frequencies, thus confirming their low heterozygosity. Genome-wide genetic divergence analysis demonstrated that TM was more closely related to CR than to CE. We further detected unusual low divergence regions between TM and CR. In addition, after applying statistical criteria to detect putative introgression regions (PIRs) in the TM genome, up to 239,620 kb PIRs (8.84% of the genome) were identified. Given that TM and CR have overlapping geographical distributions, had the same refuge during the Middle Pleistocene, and show similar mating behaviors, it is highly likely that there was an ancient introgression event between them. Moreover, demographic inferences revealed that TM exhibited a similar demographic history as other macaques until 0.5 million years ago, but then it maintained a lower effective population size until present time. Our study has provided new insight into the macaque evolutionary history, confirming hybridization events between macaque species groups based on genome-wide data.
    Molecular Biology and Evolution 03/2014; · 10.35 Impact Factor
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    ABSTRACT: Bone and fat cells share a common progenitor, stromal/mesenchymal stem cells, which can differentiate into osteoblasts or adipocytes. Osteogenesis and adipogenesis of mesenchymal stem cells maintain homeostasis under physiological conditions. Disruption of this homeostasis leads to bone-related metabolic diseases. For instance, reduction in bone formation, which is usually accompanied by an increase in bone marrow adipogenesis, occurs with aging, immobility or osteoporosis. Thus, it is crucial to gain an understanding of how osteogenic and adipogenic lineages of mesenchymal stem cells are regulated. Here, we present evidence that let-7 is a positive regulator of bone development. Using gain- and loss-of-function approaches, we demonstrate that let-7 markedly promotes osteogenesis and suppresses adipogenesis of mesenchymal stem cells in vitro. Moreover, let-7 could promote ectopic bone formation of mesenchymal stem cells in vivo. Subsequent studies reveal that HMGA2 is a direct target of let-7. RNAi depletion of HMGA2 could also enhance osteogenesis and repress adipogenesis. Overall, we found a novel role of let-7/HMGA2 axis regulates the balance of osteogenesis and adipogenesis in mesenchymal stem cells. Thus, let-7 can be used as a novel therapeutic target for disorders associated with bone loss and adipocyte accumulation.
    Stem cells and development 03/2014; · 4.15 Impact Factor
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    ABSTRACT: Nucleotide-binding oligomerization domain 2 (NOD2) is one of the most prominent member of the NOD-like receptors protein family that functions as intracellular pattern recognition receptors. Numerous studies have suggested the importance of NOD2 in defensing against microbial infections, regulation of the inflammatory process. It is shown that NOD2 contributes to the pathogenesis of various autoimmune and chronic inflammatory diseases, such as Crohn's disease, rheumatoid arthritis. The aim of this study is to summarize our current understandings of NOD2 function and the role of NOD2 in systemic lupus erythematosus (SLE). The following databases were searched: Pubmed, EMBASE and Web of Science for English-language sources, using the terms "lupus," "systemic lupus erythematosus," ''SLE," "immunity," "inflammatory" and "NOD2." Emerging data evidences that NOD2 has important biological effects in autoimmunity and inflammatory and might take part in the pathogenesis of SLE. Studies exploring the relationship between NOD2 and SLE are very limited. Whether NOD2 could be a potentially valuable therapeutic target for treatment for SLE, more understanding of the mechanism of NOD2 is needed in the future in SLE.
    Rheumatology International 03/2014; · 2.21 Impact Factor
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    ABSTRACT: To explore the effectiveness of excision and reconstruction of bone tumor by using operation guide plate made by variety of three-dimensional (3-D) printing techniques, and to compare the advantages and disadvantages of different 3-D printing techniques in the manufacture and application of operation guide plate.
    03/2014; 28(3):304-8.
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    ABSTRACT: Abstract Genetic heterogeneity is the main factor for significant variation in the course of autosomal dominant polycystic kidney disease (ADPKD). PKD1 patients have more severe renal outcomes compared with PKD2 patients. Co-inheritance of a mutation in both genes is associated with more severe phenotypes than that found with either mutation alone. However, the genotype-phenotype relationship is far from clear in ADPKD. Here, we observed two novel mutations, PKD1:c.12444G > A and PKD1:c.12444 + 1G > A, which alter the same splice donor site of intron 45, correlate with different renal outcomes. To explain the phenomenon, we analyzed the genic and allelic background of the patients, as well as the genetic modifiers, DKK3 and HNF-1β as suggested. Only PKD1 variants were found, which highlights the allelic influence of PKD1 gene to be the last candidate factor. Segregation analysis, online mutation prediction, and recurrence mutation searching were applied to sort the variants. However, none of variants was found to be damaging or associated with the disease except PKD1:c.12444G > A and PKD1:c.12444 + 1G > A. Cloning and sequencing of the mutated cDNA sequences had shown unexpected different splicing effects caused by the mutations. PKD1:c.12444 + 1G > A definitely destroyed the native splice site and created a novel donor site with truncating effect on PC1. In contrast, PKD1:c.12444G > A mainly weakened the site and decreased the expression of normal PC1. Since PC1 negatively regulates cell proliferation in the process of cyst formation and enlargement, our observation may explain this new genotype-phenotype correlation and help to improve genetic counseling and diagnosis of the disease.
    Renal Failure 02/2014; · 0.94 Impact Factor

Publication Stats

6k Citations
2,466.03 Total Impact Points

Institutions

  • 2014
    • Shenyang Pharmaceutical University
      • Department of Pharmacy
      Feng-t’ien, Liaoning, China
    • West China Hospital of Stomatology
      Hua-yang, Sichuan, China
    • Beijing Institute of Microbiology and Epidemiology
      Peping, Beijing, China
  • 2013–2014
    • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      Shanghai, Shanghai Shi, China
    • Renji Hospital
      Shanghai, Shanghai Shi, China
    • Fourth Military Medical University
      Xi’an, Liaoning, China
    • Guangxi Medical University
      Yung-ning, Guangxi Zhuangzu Zizhiqu, China
  • 2012–2014
    • Shanghai Center for Bioinformation Technology
      Shanghai, Shanghai Shi, China
    • HuaiHai Institute of Technology
      Tsin-pu, Jiangsu Sheng, China
    • Anhui University
      • School of Life Sciences
      Hefei, Anhui Sheng, China
    • The University of Arizona
      • Department of Pediatrics
      Tucson, AZ, United States
    • Peking University School of Stomatology
      Peping, Beijing, China
    • Huazhong University of Science and Technology
      Wu-han-shih, Hubei, China
    • Chinese Center For Disease Control And Prevention
      Peping, Beijing, China
    • Peking University Third Hospital
      Peping, Beijing, China
    • China Academy of Chinese Medical Sciences
      • Institute of Basic Medical Sciences
      Peping, Beijing, China
    • Wuhan Institute Of Virology
      Wu-han-shih, Hubei, China
  • 2011–2014
    • Shantou University
      • Department of Pathology
      Swatow, Guangdong, China
    • Shenyang Agricultural University
      Feng-t’ien, Liaoning, China
    • Jilin University
      • State Key Laboratory of Inorganic Synthesis and Preparative
      Jilin, Jilin Sheng, China
    • Shanghai University of Traditional Chinese Medicine
      • Department of Oncology
      Shanghai, Shanghai Shi, China
    • Virginia Polytechnic Institute and State University
      • Department of Chemistry
      Blacksburg, VA, United States
    • Peking University People's Hospital
      Peping, Beijing, China
    • Chinese PLA General Hospital (301 Hospital)
      Peping, Beijing, China
  • 2008–2014
    • Sichuan University
      • • Mental Health Center
      • • West China School of Stomatology
      Hua-yang, Sichuan, China
    • West China School of Medicine
      Hua-yang, Sichuan, China
    • Peking University
      • Institute of Mental Health
      Beijing, Beijing Shi, China
    • Southwest Petroleum University
      Hua-yang, Sichuan, China
    • Southwest University in Chongqing
      Pehpei, Chongqing Shi, China
    • Wuhan General Hospital of Guangzhou Military Command
      Wu-han-shih, Hubei, China
    • Singapore National Eye Centre
      Tumasik, Singapore
    • Henan University
      K’ai-feng-shih, Henan Sheng, China
  • 2005–2014
    • Harbin Medical University
      • • College of Bioinformatics Science and Technology
      • • Department of Geriatrics
      • • Department of Bioinformatics
      Charbin, Heilongjiang Sheng, China
    • Xiamen University
      Amoy, Fujian, China
    • Shanghai Research Institute of Chemical Industry
      Shanghai, Shanghai Shi, China
  • 2004–2014
    • Chinese Academy of Sciences
      • • State Key Laboratory of Electroanalytical Chemistry
      • • Changchun Institute of Applied Chemistry
      • • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
    • University of Arkansas
      • Department of Physics
      Fayetteville, AR, United States
  • 2003–2014
    • Ocean University of China
      • • Institute of Evolution and Marine Biodiversity
      • • Department of Pharmacology, Marine Drug and Food Institute
      • • College of Marine Life Science
      Tsingtao, Shandong Sheng, China
  • 2012–2013
    • Changchun Institute of Optics, Fine Mechanics and Physics
      Hsin-ching, Jilin Sheng, China
    • Hubei University
      Wu-han-shih, Hubei, China
  • 2011–2013
    • Stony Brook University
      • • Department of Geosciences
      • • Department of Chemistry
      Stony Brook, NY, United States
  • 2010–2013
    • National Center for Nanoscience and Technology
      Peping, Beijing, China
    • Nanjing University
      • • Department of Chemical Engineering
      • • State Key Laboratory of Pharmaceutical Biotechnology
      Nanjing, Jiangsu Sheng, China
    • South China Center for Innovative Pharmaceuticals
      Shengcheng, Guangdong, China
    • Shanxi Normal University
      Saratsi, Shanxi Sheng, China
    • Second Military Medical University, Shanghai
      Shanghai, Shanghai Shi, China
    • Jiaxing University
      Kashing, Zhejiang Sheng, China
  • 2009–2013
    • Dalian University of Technology
      • • School of Civil & Hydraulic Engineering
      • • State Key Laboratory of Coastal and Offshore Engineering
      Lü-ta-shih, Liaoning, China
    • Anhui Medical University
      • Department of Epidemiology and Biostatistics
      Hefei, Anhui Sheng, China
    • Shaoxing University
      Shao-hsing, Zhejiang Sheng, China
    • South China Normal University
      • School of Chemistry and Environment
      Guangzhou, Guangdong Sheng, China
    • University of Porto
      • Faculdade de Engenharia
      Porto, Distrito do Porto, Portugal
    • Harbin Institute of Technology
      Charbin, Heilongjiang Sheng, China
    • Chinese Academy of Medical Sciences
      • Institute of Basic Medical Sciences (IBMS)
      Peping, Beijing, China
    • Louisiana State University
      • Department of Biological Sciences
      Baton Rouge, LA, United States
    • McMaster University
      • Department of Chemistry and Chemical Biology
      Hamilton, Ontario, Canada
    • Liaoning Normal University
      Lü-ta-shih, Liaoning, China
    • South China University of Technology
      Shengcheng, Guangdong, China
  • 2008–2013
    • Xidian University
      Ch’ang-an, Shaanxi, China
    • Shanghai Municipal Center for Disease Control and Prevention
      Shanghai, Shanghai Shi, China
    • Academy of Military Medical Sciences
      T’ien-ching-shih, Tianjin Shi, China
    • Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
      Hua-yang, Sichuan, China
  • 2006–2013
    • Shanghai Jiao Tong University
      • • School of Life Science and Biotechnology
      • • Department of Ophthalmology
      • • School of Medicine
      Shanghai, Shanghai Shi, China
    • Peking Union Medical College Hospital
      Peping, Beijing, China
  • 2004–2013
    • Fudan University
      • • Institutes of Biomedical Sciences
      • • School of Pharmacy
      • • State Key Laboratory of Medical Neurobiology
      Shanghai, Shanghai Shi, China
  • 2000–2013
    • Northeast Institute of Geography and Agroecology
      • • Institute of Microbiology
      • • State Key Laboratory of Electroanalytical Chemistry
      • • State Key Laboratory of Drug Research
      • • Graduate School
      • • Institute of Process Engineering
      • • Laboratory of Cellulose and Lignocellulosics Chemistry
      Beijing, Beijing Shi, China
  • 1995–2013
    • Rutgers, The State University of New Jersey
      • Department of Chemical Biology
      New Brunswick, New Jersey, United States
  • 2011–2012
    • Sun Yat-Sen University
      Shengcheng, Guangdong, China
  • 2010–2012
    • University of Texas at Dallas
      • Department of Materials Science & Engineering
      Dallas, TX, United States
  • 2008–2012
    • Beijing Forestry University
      Peping, Beijing, China
  • 2009–2011
    • University of Leipzig
      • Institut für Experimentelle Physik
      Leipzig, Saxony, Germany
  • 2007–2011
    • University of Science and Technology of China
      • Department of Chemistry
      Hefei, Anhui Sheng, China
    • National University of Singapore
      • Singapore Eye Research Institute
      Singapore, Singapore
  • 2006–2011
    • Singapore Eye Research Institute
      Tumasik, Singapore
  • 2003–2011
    • Nanjing Medical University
      • • Department of Physiology
      • • Department of Pathophysiology
      Nanjing, Jiangsu Sheng, China
  • 2008–2010
    • Nanfang Hospital
      Shengcheng, Guangdong, China
    • University of Maryland, Baltimore
      • Institute of Human Virology
      Baltimore, MD, United States
  • 2005–2010
    • Zhejiang University
      • • Institute of Catalysis
      • • Department of Chemistry
      • • College of Life Sciences
      Hang-hsien, Zhejiang Sheng, China
  • 2005–2008
    • Nankai University
      • Institute of Modern Optics (IMO)
      T’ien-ching-shih, Tianjin Shi, China
  • 2002–2005
    • Ohio University
      • Edison Biotechnology Institute "EBI"
      Athens, OH, United States
  • 1998
    • Rider University
      Lawrenceville, New Jersey, United States