Marta González-Santander

University of Alcalá, Cómpluto, Madrid, Spain

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Publications (5)10.49 Total impact

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    ABSTRACT: A group of lecturers from diverse areas of knowledge of the University of Alcalá have implemented an experience of teaching innovation based on “reflective diaries”. The students hand in to the lecturer every week their “Weekly Reflection Papers” (WRP), in which they schematically express the most important ideas related with the topic presented during the classes of the previous week. They must include their reflections about the aspects they found especially interesting. After having applied this tool for some academic years we introduced a modification called “Guided Weekly Reflection Papers” (GWRP), where the professors suggest a series of questions on which the students must apply the most significant concepts studied each week. This modification enhances student’s motivation, encourages them to achieve more significant and reflective knowledge and generates interest in emergent topics. However, we often detect that the information management needed to solve the proposed questions in the GWRP is not the most suitable one. Therefore our present work is aimed at helping students develop the necessary skills and acquire a searching criterion in the framework of the information literacy. The strategy was focussed on some important items for the acquisition of information competencies. In this communication we analyze the progress of the GWRP tool and we explore the response of students to the information literacy approach.
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    ABSTRACT: A group of lecturers from diverse areas of knowledge of the University of Alcalá have implemented an experience of teaching innovation based on “reflective diaries”. The students hand in to the lecturer every week their “Weekly Reflection Papers” (WRP), in which they schematically express the most important ideas related with the topic presented during the classes of the previous week. They must include their reflections about the aspects they found especially interesting, making particular remark in the analysis of the teaching-learning process and also any kind of information they think worth to be given to the lecturer. The professor gives back to the students the corrected WRP in a few days and answers the student’s comments. After having applied this tool for some academic years we introduced a modification called “Guided Weekly Reflection Papers” (GWRP), which enhances student’s motivation, encourages them to achieve more significant and reflective knowledge and generates interest in emergent topics. The GWRP activity, where the professors suggest a series of questions on which the students must apply the most significant concepts studied each week, allows them to improve aspects such as autonomous work, critical and analytical mind, fusion of theory with practice as much as to develop their ability to stablish the link between their theoretical knowledge and the real life or the professional duties. However, we often detect that the information management needed to solve the proposed questions in the GWRP is not the most suitable one. The vast amount of information available in internet brings frequently the students to an indiscriminate use of it. The aim of our present work is to help the students to develop the necessary skills and acquire a searching criterion in the framework of the information literacy. The strategy was focussed on the main items for the acquisition of information competencies: • Recognize, identify and determine the extent of information needed to accomplish a specific purpose. • Build strategies for searching, finding and selecting information in an effective and efficient way. • Understand the ethical and legal issues surrounding the use of information, which implies the correct citation of the selected materials, In this communication we analyze the evolution of the activity and we explore the response of students to the methodological proposal goals. Keywords: Guided weekly reflection papers, teaching-learning tool, information literacy, information competencies
    INTED (The 9th International Technology, Education and Development Conference). Madrid (Spain). 2-4 March, 2015; 04/2015
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    ABSTRACT: Bisphenol A (BPA) is found in human urine and fat tissue. Higher urinary BPA concentrations are associated with arterial hypertension. To shed light on the underlying mechanism, we orally administered BPA (4 nM to 400 μM in drinking water) to 8-wk-old CD11 mice over 30 d. Mice developed dosage-dependent high blood pressure (systolic 130±12 vs. 170±12 mmHg; EC50 0.4 μM), impairment of acetylcholine (AcH)-induced carotid relaxation (0.66±0.08 vs. 0.44±0.1 mm), a 1.7-fold increase in arterial angiotensin II (AngII), an 8.7-fold increase in eNOS mRNA and protein, and significant eNOS-dependent superoxide and peroxynitrite accumulation. AngII inhibition with 0.5 mg/ml losartan reduced oxidative stress and normalized blood pressure and endothelium-dependent relaxation, which suggests that AngII uncouples eNOS and contributes to the BPA-induc E: d endothelial dysfunction by promoting oxidative and nitrosative stress. Microarray analysis of mouse aortic endothelial cells revealed a 2.5-fold increase in expression of calcium/calmodulin-dependent protein kinase II-α (CaMKII-α) in response to 10 nM BPA, with increased expression of phosphorylated-CaMKII-α in carotid rings of BPA-exposed mice, whereas CaMKII-α inhibition with 100 nM autocamptide-2-related inhibitor peptide (AIP) reduced BPA-mediated increase of superoxide. Administration of CaMKII-α inhibitor KN 93 reduced BPA-induced blood pressure and carotid blood velocity in mice, and reverted BPA-mediated carotid constriction in response to treatment with AcH. Given that CaMKII-α inhibition prevents BPA-mediated high blood pressure, our data suggest that BPA regulates blood pressure by inducing AngII/CaMKII-α uncoupling of eNOS.-Saura, M., Marquez, S., Reventun, P., Olea-Herrero, N., Arenas, M.I., Moreno-Gómez-Toledano, R., Gómez-Parrizas, M., Muñóz-Moreno, C., González-Santander, M., Zaragoza, C., Bosch, R.J. Oral administration of bisphenol A induces high blood pressure through angiotensin II/CaMKII-dependent uncoupling of eNOS.
    The FASEB Journal 08/2014; 28(11). DOI:10.1096/fj.14-252460 · 5.48 Impact Factor
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    ABSTRACT: New approaches are needed to the therapy of advanced prostate cancer. This study determined the effect of growth hormone-releasing hormone (GHRH) antagonists, JMR-132 and JV-1-38 on growth of PC3 tumors as well as on angiogenesis and metastasis through the evaluation of various factors that contribute largely to the progression of prostate cancer. Human PC3 androgen-independent prostate cancer cells were injected subcutaneously into nude mice. The treatment with JMR-132 (10 μg/day) or JV-1-38 (20 μg/day) lasted 41 days. We also evaluated the effects of JMR-132 and JV-1-38 on proliferation, cell adhesion and migration in PC-3 cells in vitro. Several techniques (Western blot, reverse transcription polymerase chain reaction, immunohistochemistry, ELISA and zymography) were used to evaluate the expression levels of GHRH receptors and its splice variants, GHRH, vascular endothelial growth factor (VEGF), hypoxia inducible factor (HIF)-1α, metalloproteinases (MMPs) -2 and -9, β-catenin and E-cadherin. GHRH antagonists suppressed the proliferation of PC-3 cells in vitro and significantly inhibited growth of PC3 tumors. After treatment with these analogues, we found an increase in expression of GHRH receptor accompanied by a decrease of GHRH levels, a reduction in both VEGF and HIF-1α expression and in active forms of MMP-2 and MMP-9, a significant increase in levels of membrane-associated β-catenin and a significant decline in E-cadherin. These results support that the blockade of GHRH receptors can modulate elements involved in angiogenesis and metastasis. Consequently, GHRH antagonists could be considered as suitable candidates for therapeutic trials in the management of androgen-independent prostate cancer.
    International Journal of Cancer 02/2013; 132(4). DOI:10.1002/ijc.27716 · 5.01 Impact Factor