Yu Jin Jung

Kyung Hee University, Sŏul, Seoul, South Korea

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Publications (90)227.6 Total impact

  • Yu Jin Jung · Han-Joon Kim · Beom S Jeon
    09/2015; 72(9):1077-1078. DOI:10.1001/jamaneurol.2015.1590
  • Han-Joon Kim · Yu Jin Jung · Beom S Jeon
    08/2015; 72(8):948-949. DOI:10.1001/jamaneurol.2015.0899
  • Hye-Yeon Choi · Yu Jin Jung · Hae-Won Shin
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    ABSTRACT: There are no conflicts of interest.
    Journal of the neurological sciences 07/2015; 356(1-2). DOI:10.1016/j.jns.2015.06.068 · 2.47 Impact Factor
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    ABSTRACT: The aim of this study was to observe the effects of prophylactic palivizumab on hospitalization secondary to respiratory syncytial virus (RSV) infection (RSVhospitalization) in former very low birth weight infants (VLBWI) with bronchopulmonary dysplasia (BPD). This study also sought to identify the risk factors of RSVhospitalizationin this particular infant population. A prospective observational study was conducted between September 2007 and April 2008 in seven Korean hospitals. Children with a history of very low birth weight, a diagnosis of BPD and who were <2 yr old at the onset of the RSV season were included in this study. Palivizumab injections were administered monthly for a maximum of five months during the RSV season. RSVhospitalization rates were reviewed, and RSVhospitalization rates between subgroups were categorized by gestational age, birth weight, and duration of ventilator care. A total of 90 subjects completed the follow-up interviews. The mean gestational age at birth was 26.1±1.7 weeks, and the mean birth weight was 889.4±222.2 g. The incidence of RSVhospitalization in the study population was 8.9% (8/90), and the mean hospital stay was 11.0±5.5 days, including one death. There were no statistically significant differences in the patients' demographic characteristics or risk factors for RSV hospitalization. When subgroup analyses were conducted, there were still no statistically significant differences. The administration of palivizumab prophylaxis during the entire RSV season is important in VLBWI with BPD, regardless of their gestational age and birth weight, or previous ventilator dependency. Graphical Abstract
    Journal of Korean Medical Science 07/2015; 30(7):924. DOI:10.3346/jkms.2015.30.7.924 · 1.27 Impact Factor
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    ABSTRACT: Extremely low birth weight infants (ELBWIs) have a high risk of acquiring cytomegalovirus (CMV) infection via breast milk and consequently developing serious symptoms. We evaluated whether freeze-thawing or pasteurization could prevent postnatal CMV infection transmitted through breast milk in ELBWIs. Medical records of 385 ELBWIs with whole milk feeding, and freeze-thawed or pasteurized breast milk feeding were reviewed retrospectively. Postnatally acquired CMV infection was defined as an initial negative and a subsequent positive on follow-up urine CMV DNA polymerase chain reaction screening tests. The incidence, clinical characteristics, symptoms, sequelae, and long-term outcome at corrected age [(CA): 2 years of CMV infection] were analyzed. While no infant developed CMV infection with whole milk (0/22) or pasteurized breast milk (0/62) feeding, postnatal CMV infection was diagnosed in 8% (27/301) of ELBWIs who were fed freeze-thawed breast milk. Gestational age in the CMV group was significantly lower than the control group. In 82% (22/27) of cases, CMV infection was symptomatic and was associated with increased ventilator days and ≥moderate bronchopulmonary dysplasia (BPD). Neurodevelopmental outcome and growth status at CA 2 years were not different between the study groups. Lower gestational age and freeze-thawed breast milk feeding >60% of total oral intake during the first 8 postnatal weeks were independent risk factors for acquiring postnatal CMV infection. BPD (≥moderate) was the only significant adverse outcome associated with this CMV infection. Pasteurization but not freeze-thawing of breast milk eradicated the postnatal acquisition of CMV infection through breast milk.
    Yonsei medical journal 07/2015; 56(4):998-1006. DOI:10.3349/ymj.2015.56.4.998 · 1.29 Impact Factor
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    ABSTRACT: The standard assessment method for tremor severity in Parkinson's disease is visual observation by neurologists using clinical rating scales. This is, therefore, a subjective rating that is dependent on clinical expertise. The objective of this study was to report clinicians' tendencies to under-rate Parkinsonian tremors in the less affected hand. This was observed through objective tremor measurement with accelerometers. Tremor amplitudes were measured objectively using tri-axis-accelerometers for both hands simultaneously in 53 patients with Parkinson's disease during resting and postural tremors. The videotaped tremor was rated by neurologists using clinical rating scales. The tremor measured by accelerometer was compared with clinical ratings. Neurologists tended to under-rate the less affected hand in resting tremor when the contralateral hand had severe tremor in Session I. The participating neurologists corrected this tendency in Session II after being informed of it. The under-rating tendency was then repeated by other uninformed neurologists in Session III. Kappa statistics showed high inter-rater agreements and high agreements between estimated scores derived from the accelerometer signals and the mean Clinical Tremor Rating Scale evaluated in every session. Therefore, clinicians need to be aware of this under-rating tendency in visual inspection of the less affected hand in order to make accurate tremor severity assessments.
    PLoS ONE 06/2015; 10(6):e0131703. DOI:10.1371/journal.pone.0131703 · 3.23 Impact Factor
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    ABSTRACT: The use of conditioned medium from mesenchymal stem cells may be a feasible approach for regeneration of bone defects through secretion of various components of mesenchymal stem cells such as cytokines, chemokines, and growth factors. Mesenchymal stem cells secrete and accumulate the multiple factors in conditioned medium under specific physiological conditions. In this study, we investigated whether the conditioned medium collected under hypoxic condition could effectively influence bone regeneration through enhanced migration and adhesion of endogenous mesenchymal stem cells. Cell migration and adhesion abilities were increased through overexpression of intercellular adhesion molecule-1 in hypoxic conditioned medium treated group. Intercellular adhesion molecule-1 was upregulated by microRNA-221 in mesenchymal stem cells because microRNAs are key regulators of various biological functions via gene expression. To investigate the effects in vivo, evaluation of bone regeneration by computed tomography and histological assays revealed that osteogenesis was enhanced in the hypoxic conditioned medium group relative to the other groups. These results suggest that behavioral changes of endogenous mesenchymal stem cells through mi-croRNA-221 targetedintercellular adhesion molecule-1 expression under hypoxic conditions may be a potential treatment for patients with bone defects.
    Moleculer Cells 06/2015; 38(7). DOI:10.14348/molcells.2015.0050 · 2.09 Impact Factor
  • Yu Jin Jung · III Sup Nou · Kwon Kyoo Kang
    04/2015; 28(2):263-270. DOI:10.7732/kjpr.2015.28.2.263
  • 04/2015; 28(2):271-278. DOI:10.7732/kjpr.2015.28.2.271
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    ABSTRACT: Oldenlandia diffusa (OD) is commonly used with various diseases such as cancer, arthritis, and autoimmune disease. Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). Here, we show that the therapeutic effect of OD, which was investigated both in vitro and chemically, induced HCC model. OD significantly enhanced apoptosis and antiproliferative activity and reduced migration ability of HCC cells. In vivo, OD was treated twice a day for 28 days after confirmed HCC model through 2-[(18)F]-fluoro-2-deoxy-D-glucose ((18)F-FDG) imaging. The survival in OD treated groups was shown to have a greater therapeutic effect than the control group. 28 days after OD treatment, OD treated groups resulted in a significant reduction in tumor number, size, (18)F-FDG uptake, and serum levels such as alanine transaminase, aspartate transaminase, and alkaline phosphate compared to the control group. Also, proliferated cells in tumor sites by OD were reduced compared to the control group. Furthermore, several rats in OD treated group survived over 60 days and liver morphology of these rats showed the difference between tumor mass and normal tissue. These results suggest that OD may have antiproliferative activity, inhibition of metastasis, and apoptotic effects in chemically induced HCC model and can have the potential use for clinical application as anticancer drug of the herbal extract.
    Evidence-based Complementary and Alternative Medicine 04/2015; 2015:501508. DOI:10.1155/2015/501508 · 1.88 Impact Factor
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    ABSTRACT: Pain is a common and distressing feature in Parkinson disease (PD). The major indication of subthalamic nucleus deep brain stimulation (STN DBS) is motor complications in advanced PD; however, pain reduction after STN DBS has been noted. To evaluate the long-term effect of STN DBS on pain in PD. Twenty-four patients who underwent STN DBS at the Movement Disorder Center at Seoul National University Hospital from June 1, 2005, through March 31, 2006, were studied. The assessments of pain were performed preoperatively and 8 years after surgery. Because 13 of the total 24 patients had additional 2-year postoperative data, the serial change between the preoperative and the 2- and 8-year follow-ups after surgery was also evaluated. Motor symptoms were assessed using the Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr staging scale. The severity of pain was scored according to an ordinal scale ranging from 0 (absent) to 10 (maximal pain) in 7 parts of the body (head, neck, trunk, and the upper and lower extremities on each side of the body). For each body part, the quality of pain was grouped into 1 of 4 categories: dystonic, musculoskeletal, radiculoneuritic, and central. Sixteen of the 24 patients (67%) experienced pain at baseline when not taking medication (off-state). All off-state pain at baseline improved or disappeared at 8 years after surgery. The number of body parts with pain was 21 at baseline and decreased to 11 at 8 years after the surgery. The mean (SD) and median scores of the off-state pain were 6.2 (2.5) and 7.0 at baseline and improved to 3.5 (2.2) and 2.5 at 8 years after the surgery, respectively. However, new pain developed in 18 of 24 patients (75%) during the 8-year follow-up period. The number of body parts with newly developed pain was 47, and the mean (SD) and median scores for new pain were 4.4 (3.0) and 3.0, respectively. The types of new pain at 8 years were musculoskeletal in 11 patients, central in 4 patients, radiculoneuritic in 3 patients, and dystonic in 1 patient. Pain associated with PD is improved by STN DBS, and the beneficial effect persists after a long-term follow-up of 8 years. In addition, new pain, especially the musculoskeletal type, developed in most patients, becoming a long-term distressing problem.
    03/2015; 72(5). DOI:10.1001/jamaneurol.2015.8
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    ABSTRACT: A number of studies have reported the therapeutic potential of low-intensity pulsed ultrasound (LIPUS) for induction of bone repair. This study investigated whether bone regeneration might be enhanced by application of focused LIPUS to selectively stimulate fractured calvarial bone. To accomplish this, bone defects were surgically created in the middle of the skull of rats that were subsequently exposed to focused LIPUS. Bone regeneration was assessed by repeated computed tomography imaging after the operation, as well as histologic analysis with calcein, hematoxylin and eosin and proliferating cell nuclear antigen assay. At 6 wk after surgery, bone formation in the focused LIPUS-treated group improved significantly relative to the control. Interestingly, new bone tissue sprouted from focused LIPUS target points. Histologic analysis after exposure to focused LIPUS revealed that proliferating cells were significantly increased relative to the control. Taken together, these results suggest that focused LIPUS can improve re-ossification through enhancement of cell proliferation in calvarial defect sites. Copyright © 2014 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
    Ultrasound in Medicine & Biology 02/2015; 41(4). DOI:10.1016/j.ultrasmedbio.2014.11.008 · 2.21 Impact Factor
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    ABSTRACT: Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects i...
    Evidence-Based Complementary and Alternative Medicine; 02/2015
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    Yu Jin Jung · Ill Sup Nou · Kwon Kyoo Kang
    12/2014; 2(4):370-379. DOI:10.9787/PBB.2014.2.4.370
  • Yu Jin Jung · Jin San Lee · Won Chul Shin
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    ABSTRACT: Although there are various movement disorders that can develop after thalamic stroke, isolated tremors confined to the lower extremities are rare, and their pathophysiological mechanism is unclear [1]. Here, we present a case of delayed-onset, regular, transient tremor following thalamic hemorrhage, which we confirm using surface electromyography (EMG).A previously healthy 59-year-old woman presented with sudden onset weakness and numbness in her left side. Left limb muscle power was assessed as Medical Research Council (MRC) grade 2, and sensations of pinprick and light touch were also slightly decreased. Brain computed tomography (CT) revealed an acute hemorrhage in the right thalamus, associated with intra-ventricular hemorrhage. Twenty days later, her left limb muscle power improved to MRC grade 4. However, an involuntary, coarse tremor in the left lower extremity developed two months after the stroke. The tremor was present mainly when the patient was at rest, but postural compone ...
    Neurological Sciences 12/2014; 36(7). DOI:10.1007/s10072-014-2023-y · 1.45 Impact Factor
  • 12/2014; 11(2):50-56. DOI:10.13078/jksrs.14009
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    ABSTRACT: Sirtuin 2 (SIRT2), a NAD(+)-dependent histone deacetylase, is involved in carcinogenesis and genomic instability and modulates proinflammatory immune responses. However, its role in renal inflammatory injury has not been demonstrated. In this study, we explored the expression patterns of CXCL2 and CCL2 in kidney tissue from Sirt2(-/-) and Sirt2(+/+) mice and in mouse proximal tubular epithelial (MPT) cells. CXCL2 and CCL2 were significantly downregulated at both the mRNA and the protein levels in kidneys of LPS-treated Sirt2(-/-) mice compared with those of LPS-treated Sirt2(+/+) mice. Furthermore, SIRT2 deficiency ameliorated LPS-induced infiltration of neutrophils and macrophages, acute tubular injury, and decrease of renal function. Supporting these observations, CXCL2 and CCL2 expression levels were lower in MPT cells treated with SIRT2-siRNA than in cells treated with control-siRNA, and adenovirus-mediated overexpression of SIRT2 in MPT cells significantly increased the LPS-induced expression of CXCL2 and CCL2 at the mRNA and protein levels. In addition, SIRT2 interacted with mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), and SIRT2-knockdown increased the acetylation of MKP-1 and suppressed the phosphorylation of p38 MAPK and c-Jun N-terminal kinase in LPS-treated MPT cells. SIRT2 also regulated p65 binding to the promoters of CXCL2 and CCL2. Taken together, these findings indicate that SIRT2 is associated with expression of renal CXCL2 and CCL2 and that regulation of SIRT2 might be an important therapeutic target for renal inflammatory injury.
    Journal of the American Society of Nephrology 10/2014; DOI:10.1681/ASN.2014030226 · 9.34 Impact Factor
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    ABSTRACT: Objective: To examine the prevalence of mutations in spinocerebellar ataxia (SCA) genes in patients who were clinically diagnosed with multiple system atrophy (MSA). Methods: Genetic tests for SCA were performed in 302 of 528 patients who met the diagnostic criteria for MSA based on clinical features. Generally, when a patient had cerebellar symptoms or cerebellar atrophy on neuroimaging, genetic tests for SCA types 1, 2, 3, 6, 7, and 17, and dentatorubropallidoluysian atrophy were done, and when a patient had parkinsonism without cerebellar symptoms, genetic tests for SCA types 2, 3, and 17 were done. Results: Mutations in SCA genes were found in 22 of the 302 patients (7.3%) with SCA17 comprising more than half of the mutation-positive cases. The age at disease onset in these 22 patients was not different compared with the 280 patients without mutations (55.9 ± 9.3 vs 59.2 ± 8.9, p = 0.102). All patients had urinary symptoms, and 10 patients also had orthostatic dizziness or orthostatic hypotension. A family history was reported in only 3 patients. Of note, dream enactment behavior suggesting REM sleep behavior disorder was reported in 9 of the 11 patients (81.8%) asked. Conclusions: The high proportion of patients with SCA mutations in this study indicates that genetic testing for SCA should be included for patients with MSA, especially for patients with cerebellar dysfunctions.
    Neurology 10/2014; 83(19). DOI:10.1212/WNL.0000000000000965 · 8.29 Impact Factor
  • American Journal of Medical Genetics Part A 08/2014; 164(8). DOI:10.1002/ajmg.a.36563 · 2.16 Impact Factor

Publication Stats

582 Citations
227.60 Total Impact Points


  • 2015
    • Kyung Hee University
      • College of Medicine
      Sŏul, Seoul, South Korea
    • Catholic Kwandong University
      • College of Medicine
      Gangneung, Gangwon-do, South Korea
    • International St. Mary's Hospitals
      Chemulpo, Incheon, South Korea
  • 2014–2015
    • Kyung Hee University Medical Center
      • Department of Neurology
      Sŏul, Seoul, South Korea
    • Seoul National University Hospital
      • Department of Neurology
      Sŏul, Seoul, South Korea
    • Yeungnam University
      Gyeongsan, Gyeongsangbuk-do, South Korea
    • Myongji Hospital
      Kōyō, Gyeonggi Province, South Korea
  • 2013–2015
    • Inje University Paik Hospital
      • Department of Pediatrics
      Sŏul, Seoul, South Korea
  • 2012–2015
    • Catholic University of Korea
      • College of Medicine
      Sŏul, Seoul, South Korea
    • Kangwon National University
      • Department of Biological Science/Biology
      Shunsen, Gangwon-do, South Korea
  • 2013–2014
    • Inje University
      • College of Medicine
      Kŭmhae, South Gyeongsang, South Korea
  • 2008–2014
    • Chonbuk National University Hospital
      Sŏul, Seoul, South Korea
    • Chonbuk National University
      • School of Medicine
      Tsiuentcheou, Jeollabuk-do, South Korea
  • 2007–2013
    • Hankyong National University
      • Department of Horticulture
      Anjŏ, Gyeonggi Province, South Korea
    • University of Nottingham
      • Laboratory of Biophysics and Surface Analysis
      Nottigham, England, United Kingdom
  • 2011–2012
    • Samsung Medical Center
      • Department of Pediatrics
      Sŏul, Seoul, South Korea
  • 2010–2012
    • Sungkyunkwan University
      • Department of Pediatrics
      Sŏul, Seoul, South Korea
    • Chung-Ang University
      • College of Pharmacy
      Sŏul, Seoul, South Korea
  • 2001–2012
    • Pohang University of Science and Technology
      • Department of Chemistry
      Geijitsu, Gyeongsangbuk-do, South Korea
  • 2010–2011
    • Kosin University
      Busan, Busan, South Korea