Publications (2)0 Total impact
Article: Regulation of macrophage and monocyte immune responses by water extract from the inner bark of Tabebuia avellanedae[show abstract] [hide abstract]
ABSTRACT: Tabebuia sp. (Bignoniaceae) is representative traditional herbal plants, found in tropical rain forest areas throughout Central and South America. These plants have been mostly used as a folk medicine to treat bacterial infection, blood coagulation, cancer and inflammatory diseases. In this study, we aimed to demonstrate the modulatory role of Tabebuia avellanedae in various macrophage-or monocyte-mediated immune responses using its water extract (Ta-WE). Ta-WE was able to up-regulate cell-cell interaction by decreasing the migration of cells and by enhancing CD29-mediated cell-cell adhesion, and the surface levels of adhesion molecules (CD18, CD29, and CD82) and costimulatory molecules (CD80 and CD86) linked to macrophage stimulation as seen in up-regulation of ROS release. In addition, this fraction also suppressed an alteration in the membrane levels of macrophages such as phagocytic uptake and morphological changes. Therefore, these results suggest that the water extract of T. avellanedae can strongly modulate an ability of macrophages and monocytes to manage immune cell-cell interaction in host defence system.Journal of Medicinal Plants Research. 04/2010; 4:431-438.
Article: Anti-inflammatory activity of hot water extract of Berberis koreana in lipopolysaccharide-induced macrophage-like cells[show abstract] [hide abstract]
ABSTRACT: Berberis koreana has been known as enthopharmacologically valuable plant in Korea, China and Japan. This plant has been reported to display numerous pharmacological activities such as anti-oxidative, neuroprotective, and anti-cancer effects. Although the pharmacological potentials have been demonstrated, anti-inflammatory effect of this plant has not been fully elucidated yet. To evaluate its anti-inflammatory activity, macrophages activated by lipopolysaccharide (LPS) were employed and the production of inflammatory mediators was explored in terms of understanding its molecular inhibitory mechanism. Hot water extract from B. koreana (Bk-HWE) was able to suppress the production of NO and TNF-α production and up-regulation of surface levels of costimulatory molecules such as CD80 and CD86. The anti-inflammatory effect of Bk-HWE seemed to be due to the inhibition of MAPK activation and c-fos translocation, according to immunoblotting analysis. In addition, Bk-HWE strongly suppressed the cell-cell adhesion events induced by functional activation of adhesion molecules such as CD29 and CD43. Therefore, our results suggest that Bk-HWE can be applied as an anti-inflammatory herbal medicine. To prove this assumption, further in vivo efficacy test will be continued in the following project.Journal of Medicinal Plants Research. 04/2010; 4:745-752.
Seoul, Seoul, South Korea
- College of Pharmacy