Mi Sun Choe

Keimyung University, Sŏul, Seoul, South Korea

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Publications (13)12.39 Total impact

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    ABSTRACT: Introduction: This study was conducted to investigate the relationships between the effect of sunitinib and immature microvessels which are not covered by pericytes. Materials and Methods: This study involved 29 patients with clear-cell renal cell carcinoma (RCC) who took sunitinib after radical nephrectomy or biopsy due to metastatic RCC. Associations among clinicopathological factors, responses to sunitinib, and patient survival were reviewed. CD31 was used to stain endothelial cells, and anti-α-smooth muscle actin was used to stain pericytes. Immature vessels were defined as vessels that were positive only for CD31 staining. A high pericyte coverage was defined as a rate of pericyte coverage above 40%. Results: Partial responses, disease stabilization, and disease progression constituted 51.7, 10.4, and 37.9% of cases, respectively. Nine cases had a low pericyte coverage (31.0%). In the high-pericyte-coverage group, the number of metastatic sites was smaller (p = 0.003). The overall response rate to sunitinib was greater in the high-pericyte-coverage group than in the low-pericyte-coverage group (p = 0.027). The median overall survival and the median progression-free survival were not significantly different between the high- and low-pericyte-coverage groups. Conclusion: In the high-pericyte-coverage group, the overall response rates to sunitinib were higher, and the numbers of metastatic sites were smaller. © 2014 S. Karger AG, Basel.
    Urologia Internationalis 08/2014; 94(2). DOI:10.1159/000363773 · 1.15 Impact Factor
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    ABSTRACT: We report 2 cases of minimal deviation adenocarcinoma of the cervix and tumorlets of sex cord tumor with annular tubules (SCTATs) of the ovaries, accompanied by Peutz-Jeghers syndrome. Case 1 is a 36-year-old woman and case 2 is a 35-year-old woman. Grossly, the cervix of both cases showed markedly barrel shaped enlargement with an infiltrating tumor. Microscopically, well-differentiated atypical glands were infiltrating into the entire thickness of the cervix. The ovarian masses in case 1 were diagnosed as metastatic carcinoma in mucinous cystadenoma with tumorlets of SCTATs of the ovaries. Multiple scattered tumorlets of SCTATs were also found in the ovary of case 2. By direct DNA sequencing analysis, a frame shift mutation of the STK11/LKB1 gene was identified in case 1. Case 1 represented the more aggressive clinical course, and although the patient received additional combined chemo-radiation therapy, she expired 1 year later. In general, mutation of the STK11/LKB1 gene is associated with poor clinical outcome in malignant tumors accompanied by Peutz-Jeghers syndrome.
    Journal of Gynecologic Oncology 01/2013; 24(1):92-5. DOI:10.3802/jgo.2013.24.1.92 · 1.60 Impact Factor
  • Sang Kwon Lee · Mi Sun Choe
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    ABSTRACT: Ossifying fibroma of the middle turbinate is extremely rare. We report a case of psammomatoid juvenile ossifying fibroma (PsJOF) of the middle turbinate in an 18-year-old adolescent female along with its CT, MRI and pathologic features. PsJOF of the middle turbinate may present a well-demarcated, expansile, solidly enhancing mass with focal bony destruction, which may mimic various benign and malignant neoplasms of the sinonasal area. A combination of clinical, imaging and pathologic findings is prerequisite for establishing an accurate diagnosis.
    01/2013; 68(6):449. DOI:10.3348/jksr.2013.68.6.449
  • Sang Kwon Lee · Mi Sun Choe
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    ABSTRACT: We report a case of mucosa-associated lymphoid tissue (MALT) lymphoma involving the medial rectus muscle in a 47-year-old man along with CT, MRI, 18F-fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT), and pathologic features. The lesion was manifested as a fusiform enlargement isolated to the right medial rectus muscle with involvement of its tendinous insertion. The lesion was isoattenuating to the brain on non-enhanced CT images, showing as isointense to gray matter on fast spin echo T1- and T2-weighted images with fat saturation, and showed homogeneous enhancement on contrast-enhanced CT and MR images. The maximum standardized uptake value on 18F-FDG PET/CT was 4.9 g/mL. The results of histological and immunohistochemical examinations of the specimen obtained by biopsy of the right medial rectus muscle were consistent with MALT lymphoma. It should be noted that the extraocular muscle (EOM) is a rare location for the involvement of MALT lymphoma, and MALT lymphoma of the EOM may mimic thyroid orbitopathy.
    01/2013; 68(6):453. DOI:10.3348/jksr.2013.68.6.453
  • Sang Kwon Lee · Mi Sun Choe
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    ABSTRACT: Transotic schwannoma is a condition extremely rare, and we herein report the CT, MRI, and pathologic findings of a transotic schwannoma case in a 38-year-old woman. The lesion was identified as an expansile mass in the internal auditory canal (IAC) and a mass in the middle ear cavity (MEC) on the high-resolution, bone algorithm, temporal bone CT. It was shown as the following: the hypointense masses of the cerebellopontine angle (CPA)-IAC and MEC, and the hypointense replacement of the normal high-signal intensity fluid of the cochlea, vestibule, and semicircular canals on the 3-dimensional (3D) fast imaging, employing the steady-state acquisition (FIESTA) sequence; and the intensely enhancing masses of the CPA-IAC and MEC, and the intense enhancement of the cochlea, vestibule, and semicircular canals on the 3D gadolinium-enhanced spoiled gradient-recalled echo (SPGR) sequence. The mass was removed via a transotic approach. The pathologic findings were consistent with schwannoma. The assessment of the extent of transotic schwannoma may be enhanced by the 3D FIESTA and the gadolinium-enhanced SPGR sequences.
    01/2013; 68(4):281. DOI:10.3348/jksr.2013.68.4.281
  • Sang Kwon Lee · Mi Sun Choe
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    ABSTRACT: Middle ear adenoma is a rare benign epithelial tumor. We report the CT and magnetic resonance imaging findings of a case of middle ear adenoma of neuroendocrine differentiation in a 36-year-old man. On high-resolution CT, the mass was found to fill the middle ear, in which the ossicles were embedded, but not destroyed, with outward bulging of the intact tympanic membrane. On MRI, the mass, which was intensely enhanced on 3-dimensional (3D) gadolinium (Gd)-enhanced spoiled gradient-recalled (SPGR) sequence, involved the middle ear, aditus ad antrum and a portion of mastoid antrum. Histological and immunohistochemical findings of the specimen obtained by surgical excisions were consistent with middle ear adenoma of neuroendocrine differentiation. Middle ear adenoma of neuroendocrine differentiation should be included in the differential diagnosis of an intensely enhancing mass filling the middle ear/mastoid antrum without ossicular destructions. The extent of the mass can be excellently assessed with 3D Gd-enhanced SPGR sequence.
    01/2013; 69(3):187. DOI:10.3348/jksr.2013.69.3.187
  • Sang Kwon Lee · Mi Sun Choe
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    ABSTRACT: We report CT, MRI, and initial and follow-up 18F-fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) features of a case of primary mucosal melanoma of the lacrimal drainage apparatus in a 76-year-old man. The lesion was identified as an enhancing mass of the right lacrimal sac with extension into the inferior meatus through the nasolacrimal duct on CT. It was hyperintense and hypointense compared with gray matter on T1- and T2-weighted images, respectively, and intensely enhanced on gadolinium-enhanced T1-weighted images. Initial 18F-FDG PET/CT demonstrated mild fluorodeoxyglucose uptake of the mass. Surgical biopsy confirmed the diagnosis. Periodic follow-up 18F-FDG PET/CT demonstrated recurrent disease 18 months after surgery and its progression thereafter. In primary mucosal melanoma of the lacrimal drainage apparatus, CT, MRI, and initial and follow-up 18F-FDG PET/CT may be useful for early detection of the lesion and associated bony changes, lesion characterization, initial staging, and surveillance of recurrent and metastatic diseases, respectively.
    01/2013; 69(6):421. DOI:10.3348/jksr.2013.69.6.421
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    ABSTRACT: This study was performed to investigate the relationship between cyclooxygenase-2 (COX-2) expression and apoptosis/angiogenesis in inflammatory and noninflammatory benign prostatic hyperplasia (BPH) and prostate cancer (PC). This study involved 64 BPH and 57 PC patients. The BPH histopathologies were classified by the presence of chronic inflammation as follows: noninflammatory BPH (NI-BPH; n=23) and inflammatory BPH (I-BPH; n=41). The association between the expression of COX-2, expression of Bcl-2, the apoptotic index (AI), expression of vascular endothelial growth factor (VEGF), and microvascular density (MVD) in the prostate was investigated. An overexpression of COX-2, Bcl-2, and VEGF was observed in cases of PC compared with cases of BPH. In PC, the AI was lower and MVD was higher than in BPH. In NI-BPH, I-BPH, and PC, the overexpression of COX-2, Bcl-2, and VEGF gradually increased. The AI was high in I-BPH, but did not differ significantly between the NI-BPH and I-BPH groups or between the NI-BPH and PC groups. MVD was significantly high in PC, but no significant difference was found between NI-BPH and I-BPH. A significant correlation was shown between the overexpression of COX-2 and Bcl-2, and COX-2 and VEGF. However, the AI was not correlated with the overexpression of COX-2 or Bcl-2. MVD was correlated with the overexpression of COX-2 and VEGF. COX-2 overexpression in PC is correlated with a decrease in apoptosis and an increase in angiogenesis. Chronic inflammation in BPH causes an overexpression of COX-2, which induces the increased expression of Bcl-2 and VEGF. It is likely that chronic inflammation plays a role in the intermediate step of carcinogenesis in the prostate.
    Korean journal of urology 04/2011; 52(4):253-9. DOI:10.4111/kju.2011.52.4.253
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    ABSTRACT: The purpose of this study was to evaluate the correlation between the expression of claudins and prognostic factors in patients with prostate cancer. The subjects of this study were 48 patients who had undergone surgery for prostate cancer. The Gleason score (6 or lower, 7 or higher), prostate-specific antigen (PSA) level, T stage, biochemical recurrence, local recurrence, and distant metastasis were compared according to the expression of claudin-1 and claudin-5 in prostate cancer. In the group with a low expression of claudin-1, the Gleason score was 7 points or higher in 18 cases (82%) and 6 points or lower in 4 cases (18%). In the group with a high expression of claudin-1, the Gleason score was 7 points or higher in 13 cases (50%) and 6 points or lower in 13 cases (50%). Thus, the low-expression group had more cases with a Gleason score of 7 or higher (p=0.022). The group with a low expression of claudin-5 also had more cases with a Gleason score of 7 or higher (p=0.011). The mean PSA values in the groups with a low and high expression of claudin-1 were 9.6 ng/ml and 5.6 ng/ml, respectively (p=0.007). A low expression of claudin-5 was also associated with a high PSA value (p=0.002). There was no statistical difference in the expression of claudin-1 and claudin-5 by T stage, biochemical recurrence, local recurrence, or distant metastasis. The low expression of claudin-1, claudin-5 was associated with a Gleason score of 7 or higher and a high PSA value in prostate cancer.
    Korean journal of urology 04/2010; 51(4):239-44. DOI:10.4111/kju.2010.51.4.239
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    ABSTRACT: Asymptomatic chronic inflammation of the prostate is a common finding in benign prostatic hyperplasia (BPH). We investigated how the chronic inflammation affects medical treatment for BPH. One pathologist reviewed the chronic inflammation of 82 BPH patients who underwent transrectal ultrasonography (TRUS)-guided needle biopsy. The extent of chronic inflammation was classified into 4 grades, categorized into two groups: the low-grade group and the high-grade group. We compared total, voiding, and storage International Prostate Symptom Score (IPSS) and quality of life (QoL) between the groups at baseline and 1, 3, 6, and 12 months after medical treatment for BPH. There were no significant differences in total IPSS or QoL between the groups during the follow-up period. The low-grade group showed continuous improvement of storage symptoms until 12 months; however, the high-grade group showed improvement until 3 months. Maximal improvements of QoL were observed at 6 months in the high-grade group and at 3 months in the low-grade group. There was no episode of surgery in the low-grade group, but four patients in the high-grade group (9.1%) underwent surgical treatment due to acute urinary retention or insufficient therapeutic response. Although there was no statistical significance, improvements in IPSS were higher and lasted longer in the low-grade group. We might suggest medical treatment for intraprostatic chronic inflammation in BPH patients.
    Korean journal of urology 04/2010; 51(4):266-70. DOI:10.4111/kju.2010.51.4.266
  • The Korean Journal of Pathology 01/2010; 44(4). DOI:10.4132/KoreanJPathol.2010.44.4.397 · 0.17 Impact Factor
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    ABSTRACT: The accumulation of extracellular matrix proteins is a common feature of fibrotic kidney diseases. Accumulating evidence suggests that TGF-beta and plasminogen activator inhibitor type 1 (PAI-1) promote the development of renal fibrosis by stimulating the generation and inhibiting the removal of matrix proteins. The small heterodimer partner (SHP) represses PAI-1 expression in the liver by inhibiting TGF-beta signaling, but whether SHP inhibits renal fibrosis is unknown. Here, unilateral ureteral obstruction (UUO) markedly increased the expression of PAI-1, type I collagen, and fibronectin but decreased SHP gene expression. Moreover, in kidneys of SHP-/- mice, the expression of PAI-1, type I collagen, fibronectin and alpha-smooth muscle actin (alpha-SMA) were higher compared with those in kidneys of wild-type mice. In addition, loss of SHP accelerated renal fibrosis after UUO. Adenovirus-mediated overexpression of SHP in cultured rat mesangial cells and renal tubular epithelial cells inhibited TGF-beta-stimulated expression of PAI-1, type I collagen, and fibronectin. SHP inhibited TGF-beta- and Smad3-stimulated PAI-1 promoter activities as well as TGF-beta-stimulated binding of Smad3 to its consensus response element on the PAI-1 promoter. Similarly, in vivo, adenovirus-mediated overexpression of SHP in the kidney inhibited the expression of UUO-induced PAI-1, type I collagen, fibronectin, and alpha-SMA. In summary, SHP attenuates renal fibrosis in obstructive nephropathy, making its pathway a possible therapeutic target for chronic kidney disease.
    Journal of the American Society of Nephrology 08/2009; 20(10):2162-70. DOI:10.1681/ASN.2008121232 · 9.47 Impact Factor
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    Ji Hye Jang · Sung Dong Chang · Mi Sun Choe
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    ABSTRACT: A 44-year-old man presented with a history of chronic epiphora, discharge from the right eye, and a palpable mass in the medial canthal area. Irrigation of the lacrimal system revealed bloody discharge. Orbital magnetic resonance imaging (MRI) showed a well-defined heterogeneous enhanced mass filling the lacrimal sac and upper nasolacrimal duct (NLD). A wide excision and surgical biopsy were performed. Histopathology showed the tumor to be an exophytic Schneiderian papilloma with moderate to severe dysplasia. Three months later, the mass was found to be invading the nasal cavity through the NLD. Endoscopic histopathological evaluation confirmed that it was identical to the originally identified papilloma.
    Korean Journal of Ophthalmology 07/2009; 23(2):100-3. DOI:10.3341/kjo.2009.23.2.100