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ABSTRACT: Hybrid systems model checking is a great success in guaranteeing the safety of computerized control cyber-physical systems (CPS). However, when applying hybrid systems model checking to MDPnP CPS, we encounter two challenges due to the complexity of human body: i) there is no good differential equation based models for many hu-man body parameters; ii) the complexity of human body can easily cause verification state space explosion. In attempt to address the challenges, we propose to alter the traditional approach of offline hybrid systems model checking of time-unbounded (i.e., long-run) future. Instead, we propose to carry out online (real-time) hybrid systems model check-ing of time-bounded (i.e., short-run) future. We carry out a case study on laser tracheotomy MDPnP, which shows the necessity of our proposed approach. We also carry out em-ulations based on real-world vital sign traces to show the feasibility of our proposed approach.