[Show abstract][Hide abstract] ABSTRACT: Over 50% of colorectal cancer (CRC) patients develop metastases. The aim of this study was to evaluate efficacy and tolerance of first-line FOLFIRI(R) + bevacizumab (B) treatment for metastatic CRC, and to assess genetic polymorphisms as potential markers.
Adult patients with histologically-proven, non-resectable metastatic CRC and ECOG <= 2 were included. 14-day cycles consisted of bevacizumab (5 mg/kg), irinotecan (180 mg/m2), bolus FU (400 mg/m2) and leucovorin (400 mg/m2), followed by 46-hour FU infusions (2400 mg/m2). Primary endpoint was response rate according to RECIST criteria. Secondary endpoints were overall (OS) and progression-free (PFS) survivals, response duration, and toxicity. Associations between clinical data, UGT1A1, thymidylate synthase, VEGFA polymorphisms and PFS, OS and toxicity were analyzed.
Sixty-two patients were enrolled (median age 68y). 59/62 patients were eligible and evaluable for response at 6 months: 28 showed partial response (47.5%; 95%CI; 34.3-60.9), 20 stable disease (33.9%) and 11 progression (18.6%). Grade 3/4 toxicities were as follows: neutropenia 16.1%; diarrhea 11.3%; nausea-vomiting 1.6%. Median response duration was 9.5 months (range 2.7-20); median PFS 10.3 months (range 8.8-11.7); and median OS 25.7 months (range 20.2-29.7). 11/59 initially unresectable patients were resectable after treatment. VEGFA polymorphism (rs25648) was associated with better OS (HR: 3.61; 95%CI: 1.57-8.30).
FOLFIRI(R) + bevacizumab is active with good response rate, long median OS, and a good safety profile. A VEGFA polymorphism might have a prognostic value in this malignancy.Trial registration: Clinicaltrials.gov: NCT00467142 (registration date: April 25, 2007).
[Show abstract][Hide abstract] ABSTRACT: To evaluate diaphragmatic hernias (DH) after percutaneous radiofrequency ablation (PRFA) for basal lung nodules and to detect risk factors.
Between January 2009 and December 2012, the presence of DH was retrospectively recorded in all of the patients who underwent PRFA with multitine expandable electrodes for ablation of nodules in the lower lobe. All nodules were classified into three groups according to the location of the tines after deployment relative to the diaphragm: In group 1, the tines were at a distance of >1 cm from the diaphragm; in group 2, at least one tine was in contact with the diaphragm without perforation; and in group 3, at least one tine was perforating the diaphragm.
We recorded 4 cases of DH (3 on the left side, 1 on the right side) in 156 patients (2.3 % of procedures). The delay of onset was 7.8 months. DH occurred in groups 2 (n = 1) and 3 (n = 3). Only the 3 cases that occurred on the left side were symptomatic (2 intussusceptions and 1 gastroesophageal reflux) and were surgically repaired. The electrode was positioned in the center of the diaphragm in all cases.
The central position of the electrode and the contact of at least one tine with the diaphragm after deployment seem to be a risk factor to develop DH.
CardioVascular and Interventional Radiology 02/2014; · 2.09 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: INTRODUCTION: Sarcoidosis and sarcoid reactions have been previously reported in association with cancer. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a minimally invasive test for investigating mediastinal lymph nodes PATIENTS AND METHODS: We conducted a retrospective review of 54 patients undergoing EUS-FNA in a cancer institute for suspected metastatic mediastinal lymph nodes showed by CT-imaging or positron emission tomography (PET). Patients with non-caseating granuloma identified by EUS-FNA were included RESULTS: EUS-FNA identified non-caseating granuloma in seven out of the 54 included patients. Most of them had positive PET. One patient had a prior history of sarcoidosis before the diagnosis of cancer. Another patient developed micrometastasis associated with sarcoid-like reaction. There was no adverse outcome associated with the EUS-FNA procedure CONCLUSIONS: Sarcoidosis must be included in the differential diagnosis of patients with a history of malignancy who develop mediastinal lymphadenopathy. EUS-FNA is a safe and minimally invasive test to obtain tissue diagnosis.
La Revue de Médecine Interne 06/2013; · 0.90 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: L’ablation par radiofréquence (RF) est une technique en plein essor et relativement sûre pour le traitement des métastases pulmonaires. Les lésions proches du diaphragme sont difficiles à traiter en raison du risque de brûlure de ce dernier. La perforation diaphragmatique avec constitution d’une hernie diaphragmatique est une complication évolutive rare mais grave. Son traitement est chirurgical. Nous présentons le premier cas décrit dans la littérature d’occlusion sur hernie diaphragmatique gauche à distance d’une RF pulmonaire.
Journal de Chirurgie Viscérale. 04/2013; 150(2):177–178.
[Show abstract][Hide abstract] ABSTRACT: Radiofrequency ablation (RF) is a relatively safe and reliable technique for the treatment of pulmonary metastases that has seen rapidly expanding use. Lesions situated near the diaphragm are difficult to treat by RF due to the risk of thermal injury to the diaphragm. Diaphragmatic perforation with progressive development of a diaphragmatic hernia is a rare but serious complication. Treatment is surgical. We present the first case reported in the literature of intestinal obstruction in a left diaphragmatic hernia that developed following RF treatment of a pulmonary metastasis.
Journal of Visceral Surgery 03/2013; · 1.17 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Mediastinal lymphadenopathy may be detected by CT-scan or positron emission tomography. Malignant (e.g, lung cancer, metastatic cancer, lymphoma), infectious (e.g, tuberculosis, histoplasmosis), and systemic processes (e.g, sarcoidosis) can cause mediastinal adenopathy. In the posterior and inferior mediastinum, endoscopic ultrasound visualizes and directs transesophageal fine needle aspiration of adenopathy. In the anterior mediastinum, endobronchial ultrasound visualizes and directs transbronchial fine needle aspiration of adenopathy. We discuss the role of EUS and EBUS in the evaluation of mediastinal adenopathy according to their anatomical localization.
Bulletin du cancer 06/2012; 99(7-8):761-70. · 0.61 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Screening high-risk individuals with imaging tests, such endoscopic ultrasound and computed tomography, can lead to the detection and treatment of predominantly asymptomatic premalignant lesions. These pancreatic lesions consist of resectable, mostly branch-type non invasive intraductal papillary mucinous neoplasms. Endoscopic ultrasound features of chronic pancreatitis are highly prevalent in high-risk individuals and these directly correlate with multifocal lobulocentric parenchymal atrophy due to pancreatic intraepithelial neoplasia. Long-term, multi-prospective studies are needed to determine if screening for early pancreatic adenocarcinoma and timely intervention results in decreased pancreatic cancer incidence and mortality in high-risk individuals.
La Presse Médicale 01/2011; 40(3):230-8. · 0.87 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: ObjectifsLe conseil diététique dans l’étude interventionnelle randomisée INOGAD reposait sur l’utilisation de fiches de conseil expliquées
au patient lors d’entretien en face-à-face au cours des cures successives de chimiothérapie. L’objectif de cette étude ancillaire
était d’en évaluer l’observance.
Matériel et méthodesL’observance de 33 patients du groupe bénéficiant de l’intervention nutritionnelle a été évaluée en les interrogeant sur l’application
des conseils centrés sur les besoins et les symptômes des patients: diminution de l’appétit, troubles du transit, nausées
et vomissements, troubles du goût, douleurs buccales, troubles de la déglutition et besoins des patients diabétiques. À chaque
visite, les symptômes étaient recueillis. La proportion de suivi des conseils et la proportion de prise de compléments nutritionnels
oraux par rapport à la prescription étaient mesurées.
RésultatsL’âge moyen des patients était de 76,5 ans (écarttype [ET]: 5,3 ans). Au total, 152 visites de suivi ont été effectuées, et
le symptôme le plus fréquent était la perte d’appétit. Une aide à domicile a été mise en place chez sept personnes. Des compléments
oraux ont été prescrits pour 22 patients et pris dans une proportion de 0,68 (ET: 0,41). Au cours du suivi, les troubles du
goût sont devenus plus fréquents. L’observance des conseils a été au minimum de 0,60 pour les troubles du goût jusqu’à 0,70
pour les conseils comportementaux en cas de perte d’appétit.
ConclusionLes modalités du soutien diététique reposant sur des entretiens répétés, le suivi des symptômes et des fiches de conseil a
été bien accepté par les patients âgés en cours de traitement oncogériatrique.
AimThe dietary counseling applied in the ongoing randomized control trial INOGAD was based on face to face interviewing and dietary
cards during the successive cures of chemotherapy. The aim of this ancillary study was to assess older patients’compliance
with this method.
ProcedureIn the intervention group 33 patients were assessed for compliance with advices targeted on needs and recorded symptoms: appetite
loss, bowel troubles, nausea and vomiting, taste troubles, oral pain, dysphagia, and the needs of patients with diabetes.
At each visit symptoms and compliance were assessed. Proportion of actually implemented advices or proportion of oral supplement
actually ingested related to prescription were measured.
ResultsMean patients age was 76.5 yr (Standard-Deviation, 5.3 yr). All in all, 152 follow-up visits were done and the most frequent
symptom was appetite loss. A professional help at home was implemented in 7 patients. Oral supplementations were prescribed
in 22 patients and were taken in a 0.68 (SD 0.41). During the follow-up taste troubles became more frequent. Compliance with
card advices were from 0.60 (taste troubles) to 0.70 (appetite loss).
ConclusionDietary counseling consisting in repeated consultations, symptoms follow-up and dietary cards was well received by elderly
cancer patients during the course of their chemotherapy treatment.
Mots clésIntervention nutritionnelle–Complémentation orale–Oncogériatrie–Observance–Chimiothérapie
KeywordsNutritional intervention–Dietary supplement–Onco-geriatrics–Compliance–Chemotherapy
[Show abstract][Hide abstract] ABSTRACT: Screening high-risk individuals with imaging tests, such endoscopic ultrasound and computed tomography, can lead to the detection and treatment of predominantly asymptomatic premalignant lesions.
These pancreatic lesions consist of resectable, mostly branch-type non invasive intraductal papillary mucinous neoplasms.
Endoscopic ultrasound features of chronic pancreatitis are highly prevalent in high-risk individuals and these directly correlate with multifocal lobulocentric parenchymal atrophy due to pancreatic intraepithelial neoplasia.
Long-term, multi-prospective studies are needed to determine if screening for early pancreatic adenocarcinoma and timely intervention results in decreased pancreatic cancer incidence and mortality in high-risk individuals.
[Show abstract][Hide abstract] ABSTRACT: L’étiologie des colites en zones tropicales a «évolué» depuis «l’épidémie» de sida. A côté des étiologies classiques — dominées
par l’amibiase et la bilharioze — les infections liées au sida sont responsables de diarrhée souvent profuse. Le diagnostic
est basé lorsque les examens de selles sont négatifs sur l’endoscopie digestive avec biopsies. Quant aux colites cryptogénétiques
inflammatoires, elles restent rares en zones tropicales, mais la rectocolite hémorragique, souvent surinfectée, doit être
évoquée si le traitement anti-infectieux est sans résultat.
The etiology of colitis in tropical areas has «evolved» since the «epidemic» of AIDS. Besides classical etiologies — dominated
by amebic colitis and bilharziosis — the infections associated with AIDS are responsible for often profuse diarrhea. The diagnosis
is made, when stool examinations are negative, after digestive endoscopy with biopsies. As for the inflammatory cryptogenetic
colitis, it remains uncommon in tropical regions; however, haemorrhagic rectocolitis, often surinfected, must be suspected
if the anti-infectious treatment is ineffective.