Publications (2)2.69 Total impact
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Article: Tumor necrosis factor during pregnancy and at the onset of labor and spontaneous abortion.
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ABSTRACT: The aim of this study was to evaluate the production of tumor necrosis factor (TNF) by peripheral blood cells during pregnancy, at the onset of labor and of spontaneous abortion (SA), as well as in non-pregnant women with and without a history of recurrent spontaneous abortions (RSA). The peripheral blood cells TNF production was evaluated in 28 women in the 1st trimester of pregnancy, 21 in the 2nd, and 30 in the 3rd, 47 at term labor; 43, at the onset of SA; 19 healthy and 19 RSA non-pregnant women. The statistical method used was the Mann-Whitney test. We observed (1) lack of TNF detection in the 1st gestational trimester; (2) increase of TNF production with gestational age, with the highest values being observed at labor (P<0.05); (3) high TNF production at the onset of SA; (4) no difference in the TNF production by healthy and RSA non-pregnant women. The suppression of TNF production during the 1st trimester of pregnancy seems to favor the normal development of pregnancy. It remains to be investigated whether the assessment of TNF production is a valuable prognostic parameter for the occurrence of abortion.European Journal of Obstetrics & Gynecology and Reproductive Biology 04/1999; 83(1):77-9. · 1.97 Impact Factor -
Article: Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy.
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ABSTRACT: An inhibitory serum factor of mixed lymphocyte culture (MLC) has been associated with successful pregnancy after lymphocyte transfusion in women with unexplained recurrent spontaneous abortions (RSA). Investigate whether the inhibitory serum factor of MLC is essential for a successful pregnancy. Sera from 33 healthy pregnant women and from 40 women with RSA were assessed by a one-way MLC in which the woman's lymphocytes were stimulated with her partner's lymphocytes or with third party lymphocytes. An inhibitory serum effect (inhibition > 50% as compared to normal serum) was detected in 45% of the pregnant women who had at least 1 previous parity, in 8% of the primigravidea, in 29% of those with one abortion and in 58% of those with more than one abortion. MLC inhibitory serum factor does not seem to be an essential factor for pregnancy development. Therefore, it should not be considered as a parameter for the assessment of RSA patients.Sao Paulo Medical Journal 115(4):1485-9. · 0.71 Impact Factor
