Justin J. Baker

Maine Medical Center, Portland, Maine, United States

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Publications (5)11.54 Total impact

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    ABSTRACT: Tumor mitotic rate (TMR) is an important prognostic variable for patients with thin melanoma. However it remains unclear what the significance of TMR is for more deeply invasive melanoma pathologically staged with a sentinel lymph node biopsy. We sought to determine the prognostic value of TMR in clinically node-negative T2 melanoma patients staged with sentinel lymphadenectomy. A prospective IRB-approved database of cutaneous melanoma patients treated from 09/01/1997-03/01/2011 was used to identify patients with T2 melanoma staged with a SLN. Associations were evaluated using Fisher's Exact test, and Kaplan-Meier analysis. Three hundred thirteen T2 patients were included. 19% had ulceration, 11% a positive sentinel node (SLN), and 10% recurred. 44% of patients had TMR ≥1/mm(2) . TMR ≥1/mm(2) did not predict SLN status. TMR ≥1/mm(2) was significantly associated with recurrence in SLN negative patients; only 3% of those with TMR <1/mm(2) developed a recurrence compared to 16% of those with TMR ≥1/mm(2) (P < 0.0001). Although TMR ≥1/mm(2) is not associated with risk of SLN involvement in T2 melanoma, it is a significant risk factor for recurrence when SLN negative. As such, TMR could be used to stratify follow-up regimens in SLN negative T2 patients. J. Surg. Oncol. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
    Journal of Surgical Oncology 02/2015; 111(6). DOI:10.1002/jso.23880 · 2.84 Impact Factor
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    ABSTRACT: Studies of ipilimumab have shown improved overall survival in patients with metastatic cutaneous melanoma. As a result, use of ipilimumab in patients with Stage IV melanoma is rapidly increasing. Patients with Stage IV melanoma often require urgent operations for complications from metastases, but little is known about the safety of surgical intervention for patients receiving ipilimumab. We performed a systematic review of the literature using PubMed. Our search terms were melanoma and ipilimumab. We excluded foreign language articles, review articles, and those not addressing cutaneous melanoma. We identified 194 publications matching the search criteria. Only six of those met the inclusion criteria. In these six publications, seven patients who had undergone surgical intervention during treatment with ipilimumab were described. There were no documented surgical complications. We reviewed our institutional experience and identified an additional three patients. No postoperative complications could be attributed directly to ipilimumab. There are limited data on the safety of surgical intervention during treatment with ipilimumab. Preliminary reports suggest there is no reason to withhold or delay surgery for patients receiving ipilimumab therapy.
    The American surgeon 08/2014; 80(8). · 0.92 Impact Factor
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    ABSTRACT: Background Follow-up of patients with sentinel lymph node–positive stage III melanoma uses history, physical exam, and cross-sectional imaging. The aim of this study was to evaluate positron emission tomographic (PET)/computed tomographic (CT) scans in the detection of recurrence. Methods From 2003 to 2009, a single-institution prospective database of all cutaneous melanoma patients was used to identify sentinel lymph node–positive stage III patients with disease-free survival >1 year and 1 restaging PET/CT scan. Results Thirty-eight patients were identified, with a median follow-up period of 27.5 months. Seven (18%) developed recurrence (median time to recurrence, 25 months). Recurrences were detected as follows: 3 by patients, 1 by physician, 1 by PET/CT scan and lactate dehydrogenase, 1 by PET/CT scan, and 1 by brain magnetic resonance imaging. One hundred eight follow-up PET/CT scans were performed. Two of 38 patients had asymptomatic metastases detected by routine restaging PET/CT scan, and there were 9 scans with false-positive results. Conclusions With short follow-up, the utility of routine PET/CT scans in identifying unsuspected recurrence in patients with sentinel lymph node–positive stage III melanoma appears minimal.
    American journal of surgery 04/2014; 207(4):549–554. DOI:10.1016/j.amjsurg.2013.04.012 · 2.41 Impact Factor
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    ABSTRACT: Patients with sentinel lymph node (SLN) positive melanoma have a significant recurrence risk. We sought to examine variables associated with development of early recurrence. A prospective institutional review board-approved database of cutaneous melanoma patients treated from 2003 to 2010 was used to identify SLN positive stage III patients with 1 year of follow-up. The Kaplan-Meier method, and logistic regression were used to evaluate variables associated with early recurrence. Seventy-four patients were identified. Twenty-four (32%) had an early recurrence. Five variables were highly significantly associated with early recurrence: location of head/neck, Breslow depth greater than two, ulceration, number of lymph nodes positive ≥ 2, and largest lymph node metastasis > 1 mm. Using these five variables, a numerical risk score was created from 0 to 5 to determine if an early recurrence occurred as the number of risk factors increased. The proportion of patients with early recurrence increased in linear fashion with increasing risk score (P < 0.0001). These data suggest that SLN positive stage III melanoma patients have a significant risk of early recurrence, which is associated with several defined variables and increases with the number of risk factors present. These data may be useful in stratifying patients to level of recurrence risk and adjusting follow-up schedules.
    The American surgeon 07/2012; 78(7):808-13. · 0.92 Impact Factor
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    ABSTRACT: Recent guidelines recommend considering central lymph node dissection (CLND) in patients with papillary thyroid cancer. We set out to examine trends in regionalization of thyroidectomy and utilization of lymphadenectomy (LND).Methods The Nationwide Inpatient Sample database was used to examine trends in thyroid cancer surgery. All patients undergoing thyroidectomy for cancer from 1999-2008 were included. Hospitals were defined as Rural(R), Urban Non-Teaching (UNT), or Urban Teaching (UT).ResultsThyroidectomy for cancer increased from 13,940 in 1999 to 23,814 in 2008. The proportion of thyroidectomies at each hospital type has not changed. Utilization of LND has increased as a proportion of all thyroidectomies from 8% in 1999 to 13% in 2008 (p<0.001). In 1999 the proportion undergoing LND was equal between the three hospital types (p=0.26). However, by 2008 an LND was most likely to be performed at an UT compared to either an UNT (Odds Ratio (OR) 1.47 (95% CI 1.31-1.56; p<0.001)) or R (OR 4.20 (95% CI 3.14-5.63; p<0.001)). Length of stay (LOS) and hypocalcaemia rates were higher when a lymphadenectomy was performed, (OR 1.64 (95% CI 1.45-1.86; p<0.001) and 1.30 (95% CI 1.18-1.43;p<0.001)) respectively, although other complications were not increased.Conclusions Thyroidectomy for cancer has increased significantly in the past decade. Although no change was observed in the proportion of cases performed by hospital type, patients at an UT hospital were more likely to undergo a lymphadenectomy than at other hospital types. LOS and hypocalcemia are inversely proportional to the rates of lymphadenectomy
    Journal of the American College of Surgeons 09/2011; 213(3):S114. DOI:10.1016/j.jamcollsurg.2011.06.269 · 4.45 Impact Factor