Constantinos Mihas

Aghia Sophia Children’s Hospital, Athínai, Attica, Greece

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Publications (67)180.21 Total impact

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    ABSTRACT: Background: One of the promises of human genetics is individualized therapy. Therefore, we evaluated the impact of CYP3A5 gene polymorphism on the effectiveness of simvastatin (a HMG-CoA reductase inhibitor). Methods: Patients (n = 191) with hypercholesterolemia were treated with simvastatin for at least 6 months and were genotyped for the CYP3A5 polymorphism. Results: The frequency of CYP3A5 polymorphism was 0.5% for WT (wild-type), 15.6% for HT (heterozygous, expressors) and 83.9% for HM (homozygous, non-expressors). Differences in lipid profile before and after dose-response of simvastatin treatment were described as % difference {[(variable after-variable before)/variable before]*100}. There was a trend towards the decrease of low density lipoprotein cholesterol (LDL-C) in HT individuals who had a -35.2% reduction with a dose of 20 mg simvastatin and HM individuals who had a slightly higher decrease (-37.5%) despite the lower dose of simvastatin (10 mg, p = 0.07). Furthermore, HT genotype individuals had significantly higher than expected (6-8%) LDL-C % difference between 20 and 40 mg of simvastatin (-35.2 vs -49.2%, p = 0.037). In individuals with HM genotype a significant LDL-C % difference was found between 10 and 40 mg of simvastatin (-37.5 vs -48.4%, p = 0.023). Conclusion: The individuals with HM polymorphism display a trend towards higher LDL-C reductions compared with HT polymorphism. Within the same genotype, differences between doses were also observed. These findings need to be confirmed in larger studies.
    The Open Cardiovascular Medicine Journal 01/2014; 8:12-7.
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    ABSTRACT: This national study of schoolchildren in Greece investigated the association between adolescents' subjective health complaints (SHC) and a number of family characteristics. Questionnaires were completed by a random, school-based sample of children from 12 to 18-years-of-age, and one of their parents (76.6% mothers), in 2003. Data from 1,041 adolescent-parent pairs were analysed. Multiple linear regression analysis was used to assess the associations between the adolescent's SHC and the following characteristics: parent's marital status, parent's physical and mental health status, parent's worries about their child's SHC, the parent-child relationship, family cohesion, family socio-economic status and the adolescent's sex and age. The analysis showed that the adolescents' SHC were independently and significantly correlated with poor parental subjective mental health status, poor quality parent-child relationships and parental worry. There were also associations between levels of SHC and female and older adolescents. Certain family features can be seen as potential contributing factors to SHC in adolescence, and should, therefore, constitute complementary targets for prevention and treatment planning. This article is protected by copyright. All rights reserved.
    Acta Paediatrica 10/2013; · 1.97 Impact Factor
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    ABSTRACT: Data regarding the quantitative expression of TCR Vbeta subpopulations in children with autoimmune diseases provided interesting and sometimes conflicting results. The aim of the present study was to assess by comparative flow cytometric analysis the peripheral blood CD4+ TCR Vbeta repertoire of children with an organ-specific autoimmune disorder, such as type 1 diabetes mellitus (T1DM), in comparison to children with a systemic autoimmune disease, such as Systemic Lupus Erythematosus (SLE) in comparison to healthy age-matched controls of the same ethnic origin. The CD4+ TCR Vbeta repertoire was analysed by flow cytometry in three groups of participants: a) fifteen newly diagnosed children with T1DM (mean age: 9.2 +/- 4.78 years old), b) nine newly diagnosed children with SLE, positive for ANA and anti-dsDNA, prior to treatment (mean age: 12.8 +/-1.76 years old) and c) 31 healthy age-matched controls (mean age: 6.58 +/- 3.65 years old), all of Hellenic origin. CD4 + TCR Vbeta abnormalities (+/- 3SD of controls) were observed mainly in SLE patients. Statistical analysis revealed that the CD4 + Vbeta4 chain was significantly increased in patients with T1DM (p < 0.001), whereas CD4 + Vbeta16 one was significantly increased in SLE patients (p < 0.001) compared to controls. CD4 + Vbeta4 and CD4 + Vbeta16 chains could be possibly involved in the cascade of events precipitating the pathogenesis of T1DM and SLE in children, respectively.
    BMC Immunology 08/2013; 14(1):33. · 2.61 Impact Factor
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    Scoliosis 06/2013; 8(1). · 1.31 Impact Factor
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    ABSTRACT: ΠΕΡΙΛΗΨΗ Εισαγωγή: Πολυάριθμες μελέτες έχουν επιχειρήσει να ποσοτικοποιήσουν την συσχέτιση μεταξύ της παραμόρφωσης της επιφάνειας και της γωνίας Cobb, χωρίς να λαμβάνεται υπόψη ότι η ανάπτυξη θα μπορούσε να αποτελεί σημαντικό παράγοντα σε αυτή την συσχέτιση. Στη δική μας σειρά παρατηρήσαμε ότι σε νεότερα παιδιά από τον μαζικό μαθητικό προληπτικό έλεγχο για σκολίωση, υπάρχει ασυμφωνία στις μετρήσεις του σκολιόμετρου στην θωρακική μοίρα της σπονδυλικής στήλης (παραμόρφωση του Θωρακικού κλωβού) με την μορφολογία αυτής καθεαυτής της σπονδυλικής στήλης. Δηλαδή ενώ υπάρχει πλευρικός ύβος, δεν παρατηρείται κύρτωμα στην ΣΣ ούτε μετρήσιμη γωνία Cobb στις ακτινογραφίες, δυσαναλογία που χάνεται όμως σε μεγαλύτερα παιδιά. Με βάση αυτήν την παρατήρηση υποθέσαμε ότι στα σκολιωτικά παιδιά η συσχέτιση μεταξύ της παραμόρφωσης του θωρακικού κλωβού και αυτής της ΣΣ είναι ασθενής σε νεότερα παιδιά και το αντίστροφο. Μέθοδος και υλικό: Στην μελέτη συμπεριλήφθηκαν 83 κορίτσια με μέσο όρο ηλικίας τα 13,4 έτη (εύρος 7-18) στα οποία παρατηρήθηκε ύβος κατά την μέτρηση με το σκολιόμετρο. Η παραμόρφωση της ΣΣ εκτιμήθηκε με την μέτρηση της θωρακικής γωνίας Cobb από τις οπισθοπρόσθιες ακτινογραφίες της ΣΣ. Ο θωρακικός κλωβός (ΘΚ) εκτιμήθηκε μετρώντας τον πλευρικό δείκτη (ΠΔ) στην κορυφή του θωρακικού κυρτώματος από τις πλάγιες ακτινογραφίες της ΣΣ. Ο ΠΔ ορίζεται ως ο λόγος των δύο αποστάσεων (d1/d2). Η πρώτη (d1) είναι η απόσταση μεταξύ του οπισθίου ορίου του σπονδυλικού σώματος του σπονδύλου που αντιστοιχεί στο πιο μακρινό σημείο του περιγράμματος της περισσότερο προεξέχουσας πλευράς και αυτού του ιδίου σημείου. Η δεύτερη (d2) είναι η απόσταση μεταξύ του οπισθίου ορίου του ίδιου σπονδυλικού σώματος και του πιο μακρινού σημείου του περιγράμματος της λιγότερο προεξέχουσας πλευράς. Έγινε γραμμική ανάλυση παλινδρόμησης με και χωρίς την επίδραση του μεταβλητού παράγοντα "ηλικία". Διαχωρίστηκε το δείγμα μας σε δύο υποομάδες, που αποτελείται από νεότερους (7-13 ετών) και μεγαλύτερους συμμετέχοντες (14-18 ετών) από τον μέσο όρο ηλικίας. Πραγματοποιήθηκε ξεχωριστή μονοπαραγοντική γραμμική ανάλυση παλινδρόμησης για κάθε υποομάδα, προκειμένου να εκτιμηθεί η επίδραση της ηλικίας στην γωνία Cobb και στην συσχέτιση του ΠΔ. Αποτελέσματα: 25% των ασθενών με στροφή του κορμού ≥7° είχαν καμπύλη στην ΣΣ <10° ή είχαν ευθεία ΣΣ. Η γραμμική ανάλυση παλινδρόμησης μεταξύ της εξαρτημένης μεταβλητής "θωρακική γωνία Cobb" με την ανεξάρτητη μεταβλητή "ΠΔ" χωρίς την επίδραση της εξαρτημένης μεταβλητής "ηλικία" δεν ήταν στατιστικά σημαντική. Μετά τον διαχωρισμό του δείγματος η γραμμική συσχέτιση ήταν στατιστικά σημαντική στην ηλικιακή ομάδα 14-18 έτη (p<0,03). Συμπεράσματα: Η ανάπτυξη έχει σημαντική επίδραση στην συσχέτιση μεταξύ της θωρακικής παραμόρφωσης και της παραμόρφωσης της ΣΣ στα κορίτσια με ιδιοπαθή σκολίωση. Για αυτό πρέπει να λαμβάνεται υπόψη όταν επιχειρείται να εκτιμηθεί η παραμόρφωση της ΣΣ από μετρήσεις της επιφάνειας του κορμού. Τα ευρήματα της παρούσας μελέτης εμπλέκουν τον ρόλο του θώρακα, καθώς φαίνεται ότι η παραμόρφωση του ΘΚ προηγείται της παραμόρφωσης της ΣΣ στην παθογένεια της ιδιοπαθούς σκολίωσης (ΙΣ).
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    ABSTRACT: Single nucleotide polymorphisms of angiotensin-converting enzyme (ACE) such as rs1799752, nuclear factor kappa B (NFkB) such as rs28362491 and cholesteryl ester transport protein (CETP) such as rs708272 (TaqB1) and rs5882 (I405V) were evaluated in nonagenarians, centenarians, and average life span individuals (controls). The study population (n = 307; 190 nonagenarians, 12 centenarians and 105 middle-aged controls) was genotyped for ACE, NFkB, and CETP genetic variants. The age of nonagenarian and centenarian group ranged between 90 and 111 years; centenarians and controls age ranged from 99 to 111, and from 18 to 80 years, respectively. The I carriers of ACE I/D gene were fewer in nonagenarians compared to centenarians (37.6% vs 62.5%, P = .016). The I carriers of ACE gene were more frequent in centenarians compared to controls (62% vs 41%, P = .045). No differences in frequency of common NFkB and CETP genotypes between patients with exceptional longevity and middle-aged patients were observed.
    Angiology 02/2013; · 2.37 Impact Factor
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    ABSTRACT: Aims: There is an increased interest in the psychosocial impact of pediatric skin diseases on children and their families. The present study tried to examine possible differences regarding mental health problems among children with alopecia areata (AA) or atopic dermatitis (AD), and their parents. Study Design: Cross-sectional study. Place and Duration of Study: Department of Dermatology, “Penteli” Children’s Hospital and Department of Dermatology, Athens University Medical School, “Andreas Syggros” Hospital, Athens, Greece, between February 2004 and February 2009. Methodology: Parents of 51 pediatric outpatients (54.9% boys) with a diagnosis of either AD or AA (mean age = 8.0 ± 1.8 years) and a control group of 12 children and their parents completed the Symptom Checklist-90-R (SCL-90-R) and the Child Behavior Checklist (CBCL). Differences among AA, AD, and the control group were examined. Results: Both AA and AD groups had significantly (P < .001) higher mean values across several CBCL scales compared to healthy controls. However, the controls seemed to exhibit less mental health symptoms than the normative Greek samples, a finding reducing the value of the control group. Children’s Anxious/Depressed, Withdrawn, Somatic complaints and Social problems had significantly higher mean values in the AA group compared to the AD group. Parental mental health symptoms did not differ significantly between the two disease groups, but they were significantly higher in patient groups compared to control group. Conclusion: Children’s and parents’ mental health symptoms may be important targets of thorough assessment and treatment among pediatric AD and AA populations.
    British Journal of Medicine and Medical Research. 01/2013; 3(1):162-172.
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    ABSTRACT: Background To investigate possible differences in emotional/behavioral problems and cognitive function in children with nephrotic syndrome compared to healthy controls and to examine the effect of disease-specific and steroid treatment-specific characteristics on the abovementioned variables. Methods Forty-one patients with nephrotic syndrome (23 boys, age range: 4.4-15.2 years) and 42 sex- and age-matched healthy control subjects (20 boys, age range: 4.1-13.4 years) were enrolled in the study. Disease (severity, age of diagnosis, duration) and steroid treatment (total duration, present methylprednisolone dose and duration of present dose) data were collected. In order to assess children's emotional/behavioral problems, the Child Behavior Checklist was administered. The Wechsler Intelligence Scale for Children -- Third Edition was administered to assess Full-Scale, Verbal, and Performance intelligence quotient (IQ) scores. Results The patients presented with more internalizing problems (P = 0.015), including withdrawal (P = 0.012) and somatic complaints (P = 0 .011), but not more anxiety/depression or externalizing problems. A significant association was found between severity of disease and somatic complaints (P = 0.017) as well as externalizing problems (P = 0.030). Years of illness were significantly more in those presenting with abnormal anxiety/depression (P = 0.011). Duration of steroid medication was significantly higher among those presenting with abnormal anxiety/depression (P = 0.011) and externalizing problems (P = 0.039). IQ was not associated significantly with disease or steroid treatment variables. Conclusions Psychosocial factors and outcomes may be important correlates of children's nephrotic syndrome and potential targets of thorough assessment and treatment.
    BioPsychoSocial Medicine 01/2013; 7:10.
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    ABSTRACT: Background: Numerous studies have attempted to quantify the correlation between the surface deformity and the Cobb angle without considering growth as an important factor that may influence this correlation. In our series, we noticed that in some younger referred children from the school-screening program there is a discrepancy between the thoracic scoliometer readings and the morphology of their spine. Namely there is a rib hump but no spinal curve and consequently no Cobb angle reading in radiographs, discrepancy which fades away in older children. Based on this observation, we hypothesized that in scoliotics the correlation between the rib cage deformity and this of the spine is weak in younger children and vice versa. Methods: Eighty three girls referred on the basis of their hump reading on the scoliometer, with a mean age of 13.4 years old (range 7-18), were included in the study. The spinal deformity was assessed by measuring the thoracic Cobb angle from the postero-anterior spinal radiographs. The rib cage deformity was quantified by measuring the rib-index at the apex of the thoracic curve from the lateral spinal radiographs. The rib-index is defined as the ratio between the distance of the posterior margin of the vertebral body and the most extended point of the most projecting rib contour, divided by the distance between the posterior margin of the same vertebral body and the most protruding point of the least projecting rib contour. Statistical analysis included linear regression models with and without the effect of the variable age. We divided our sample in two subgroups, namely the younger (7-13 years old) and the older (14-18 years old) than the mean age participants. A univariate linear regression analysis was performed for each age group in order to assess the effect of age on Cobb angle and rib index correlation. Results: Twenty five per cent of patients with an ATI more than or equal 7 degrees had a spinal curve under 10 degrees or had a straight spine. Linear regressions between the dependent variable "Thoracic Cobb angle" with the independent variable "rib-index" without the effect of the variable "age" is not statistical significant. After sample split, the linear relationship is statistically significant in the age group 14-18 years old (p < 0.03). Conclusion: Growth has a significant effect in the correlation between the thoracic and the spinal deformity in girls with idiopathic scoliosis. Therefore it should be taken into consideration when trying to assess the spinal deformity from surface measurements. The findings of the present study implicate the role of the thorax, as it shows that the rib cage deformity precedes the spinal deformity in the pathogenesis of idiopathic scoliosis.
    Acta Orthopaedica et Traumatologica Hellenica. 01/2013; 64(1):11-16.
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    ABSTRACT: We compared the efficacy of atorvastatin with simvastatin according to cholesteryl ester transfer protein (CETP) and adenosine triphosphate-binding cassette transporter A1 (ABCA1) genes. Patients treated with atorvastatin (n = 254) or simvastatin (n = 332) were genotyped for CETP (TaqIB and I405V) and ABCA1 (R219K) genetic variants. For genotype B1B2, atorvastatin compared with simvastatin treatment resulted in a greater decrease in total cholesterol (35.4% vs 31.6%, P = .035) and a lower increase in high-density lipoprotein cholesterol (2% vs 8%, P = .05). For genotype B2B2, atorvastatin compared with simvastatin treatment resulted in a lower decrease in low-density lipoprotein cholesterol (31.85 vs 42%, P = .029). For genotypes RR and KK, atorvastatin compared with simvastatin treatment resulted in a greater decrease of triglycerides (27% vs 17% and 35% vs 15%, respectively; P = .02 for all comparisons). ΤThe TaqIB and R219K (opposite to I405V) gene polymorphisms seem to modify the response to lipid-lowering therapy with simvastatin or atorvastatin treatment.
    Angiology 05/2012; · 2.37 Impact Factor
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    ABSTRACT: OBJECTIVES: Osteopontin (OPN) is a multifunctional protein associated with vascular injury and has been linked to atherosclerosis and inflammation. We sought to investigate whether OPN changes in relation to coronary artery by-pass grafting (CABG) surgery. DESIGN AND METHODS: We studied 50 consecutive patients (63±10years old, 6 women and 44 men) undergoing elective CABG. Plasma OPN levels were determined by an enzyme-linked immunosorbent assay at baseline and in 24 and 72h, post-operatively. Cardiac enzymes - creatine kinase, the MB isoenzyme of creatine kinase, troponin-I- and C-reactive protein (CRP) were also determined at all three time points. RESULTS: OPN levels 72h post-op decreased significantly compared to pre-op and 24h post-op levels (p<0.001) whereas there was no difference between the pre-op and first post-op values (p=0.57). The relative change in OPN levels between pre-op and 72h post-op correlated negatively with absolute troponin-I levels at 72h post-op (-0.51, p=0.005). OPN levels 72h post-op correlated significantly with CRP at baseline (r=0.73, p=0.002). CONCLUSIONS: OPN plasma concentrations decreased after CABG surgery in the early post-operative period. The significance of this observation needs further investigation.
    Clinical biochemistry 05/2012; · 2.02 Impact Factor
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    Scoliosis 01/2012; 7 Suppl 1:O74. · 1.31 Impact Factor
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    ABSTRACT: Background. The aim of the study was to investigate the changes in plasma lipids and lipoproteins and the cardiovascular events after selective LDL apheresis. Methods and Results. Two pediatric patients with familial hypercholesterolemia aged 11 and 13 years and 19 dyslipidemic adults aged 41 ± 14 years underwent direct adsorption of lipoproteins (DALI) sessions. The mean follow-up period was 47 ± 23 months. The total cholesterol (TC) values before and after treatment were 8.2 ± 2.2 and 3.1 ± 1.6 mmol/l (318 ± 86 and 122 ± 62 mg/dL), respectively. The interval mean of TC was 6.9 ± 1.9 mmol/l (268 ± 75 mg/dL). The LDL cholesterol concentrations before and after treatment were 6.6 ± 2.1 and 1.7 ± 1.1 mmol/l, (256 ± 82 mg/dL and 65 ± 41 mg/dL), respectively. The percentage of acute LDL cholesterol reduction was 75 ± 11%. Cardiovascular events were observed in seven patients. The average annual event rate was 5.51%. Conclusion. LDL apheresis is a very important therapeutic tool in managing patients at high risk for premature CAD or with aggressive CAD, despite adequate medical treatment.
    Cholesterol 01/2012; 2012:976578.
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    ABSTRACT: Trunkal back asymmetry is considered very important for the selection of children at risk of developing scoliosis. Traditionally, this asymmetry as thoracic or lumbar hump is the main indicator for referral of subjects with idiopathic scoliosis (IS) to clinics from school-screening programs. This asymmetry is also used as the most important sign for further assessment at scoliosis clinics. There are reports suggesting that an epigenetic risk factor for IS is maternal age at birth. However, the influence of maternal age on the development of trunkal asymmetry during growth has not been reported. This report aims to assess if maternal age at birth impacts trunkal asymmetry, and how this parameter may dictate the epigenotypic expression of the trunkal asymmetry of a child. The sample examined: 11832 (5855 males and 5977 females) children and adolescents (5-17 years old, mean age: 11.34±2.79) were screened at their school for back trunkal asymmetry and/or scoliosis. The measurements: The Prujis scoliometer was used to examine the students in standing and sitting forward bending positions. If at least one of child's measured angles was equal to or exceeded 6 or 7 degrees of scoliometer reading, it was labelled as "Asymmetry-6" and "Asymmetry-7" respectively. The age, standing height and body weight of children and maternal age were also documented, among other parameters. The maternal age at birth and children's BMI were subsequently calculated. The statistical analysis: Asymmetries were tested for correlation with maternal age at birth which was transformed to a categorical variable using 5-year intervals. Pearson's χ2 test was used for the univariate analysis, while logistic regression was used for quantitative univariate and multivariate analysis. Statistical significance level was set to p<.05. SPSS and STATA TM v. 11.0 statistical packages were used for the analysis. Univariate analysis: Univariate analysis showed that the prevalence of asymmetry-6 in boys tended to significantly decrease as mother's age at birth increased (mother's age at birth: <19, 20-24, 25-29, 30-34, 35-39, >40 years, % of asymmetry-6: 11.5%, 9.5%, 8.5%, 7.6%, 5.2%, 5.3%, respectively, (p=0.026). This trend, although present, was not significant in girls. The prevalence of asymmetry-7 also showed a decreasing trend, which was only significant in boys (mother's age at birth: <19, 20-24, 25-29, 30-34, 35-39, >40 years, % of asymmetry-7: 8.7%, 5.9%, 5.9%, 4.6%, 2.6%, 3.5%, respectively, p=0.010). Maternal age at birth, as a continuous variable, was inversely associated with the appearance of asymmetry-6 in both boys and girl s (OR: 0.966, 0.982, 95%CIs: 0.947-0.985, 0.965-0.999, p: 0.001, 0.040, respectively). This was also the case for asymmetry-7 only in boys: (OR: 0.961, 0.982, 95%CIs: 0.938-0.985, 0.962-1.003, p: 0.001, 0.088, respectively). Multivariate analysis: The significant and inverse effect of maternal age at birth on the appearance of asymmetry in boys remained even after adjusting for child's BMI and age. For one year increase of maternal age at birth, the odds of the boys being asymmetrical6 were reduced by 2.8% (OR:0.972, 95% CIs: 0.953-0.992, p: 0.005), adjusting for child's age and BMI. For one year increase of maternal age at birth, the odds of the boys being asymmetrical7 were reduced by 3.2% (OR:0.968, 95% CIs: 0.945-0.992, p: 0.010), adjusting for child's age and BMI. However, the aforementioned correlations were not significant for girls in both cases. The influence of maternal age at birth on the development of trunkal asymmetry during growth has not been previously assessed, as evidenced from literature review. The findings of this report indicate that maternal age as an environmental factor in the general population, may possibly influence epigenetically, the occurrence of the initial presentation of trunkal asymmetry in males more than females, as well as IS during growth. Consistent findings reported from the USA, Edinburgh and Sweden reveal increased maternal age as a risk factor for AIS, suggesting maternal factors can predispose to it. It seems that males are more affected by this factor but, unexpectedly in this study, by younger and not older mothers, as reported for AIS in the literature. Low-birth weight associated with younger parental age may also be associated with increased trunkal asymmetry particularly of boys, an hypothesis that need testing. The importance our findings is based on the belief that the intra-uterine environment is crucial in programming the fetus for various health and disease outcomes throughout life.
    Studies in health technology and informatics 01/2012; 176:36-42.
  • European Journal of Internal Medicine 10/2011; 22. · 2.30 Impact Factor
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    ABSTRACT: This study examined prospectively the role of parental psychopathology among other predictors in the development and persistence of posttraumatic stress disorder (PTSD) in 57 hospitalized youths aged 7-18 years immediately after a road traffic accident and 1 and 6 months later. Self report questionnaires and semistructured diagnostic interviews were used in all 3 assessments. Neuroendocrine evaluation was performed at the initial assessment. Maternal PTSD symptomatology predicted the development of children's PTSD 1 month after the event, OR = 6.99, 95% CI [1.049, 45.725]; the persistence of PTSD 6 months later was predicted by the child's increased evening salivary cortisol concentrations within 24 hours of the accident, OR = 1.006, 95% CI [1.001, 1.011]. Evaluation of both biological and psychosocial predictors that increase the risk for later development and maintenance of PTSD is important for appropriate early prevention and treatment.
    Journal of Traumatic Stress 08/2011; 24(4):414-21. · 2.72 Impact Factor
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    ABSTRACT: Background/Aim: Triglycerides (TGs) are measured in studies evaluating changes in non-fasting lipid profiles after a fat tolerance test (FTT); however, the optimal timing for TG measurements after the oral fat load is unclear. The aim of this study was to evaluate how non-fasting TG levels vary after an oral FTT in healthy subjects. Methods: This meta-analysis included 113 studies with >5 participants of Caucasian race that were indexed in PubMed from its inception through March 2010, using the search term “postprandial lipemia”. We only included studies that provided mean values and standard deviation (SD) (or standard error of the mean) for TG measurements at baseline (=fasting) and for at least one other time-point. Exclusion criteria included uncommon sampling time-points after the FTT, baseline TGs≥2.0 mmol/L (≥177mg/dl), and a body mass index ≥30kg/m2. Results: All studies combined, weighted mean±SD TG values in mmol/L were 1.25±0.32 fasting, 1.82±0.40 at 2 h, 2.31±0.62 at 4 h, 1.87±0.63 at 6 h, and 1.69±0.80 at 8 h. After stratifying studies based on fat quantity in the test meal (<40,≥40-<50, ≥50-<60, ≥60-<70, ≥70-<80, ≥80-<90, ≥90-<100, ≥100- <110, ≥110-120, ≥120 g), the highest standardized mean difference in TG levels from fasting levels was found in those having an oral fat load of ≥70 g and <80 g, and at 4 h (difference=1.74 mmol/L; p<0.001). Conclusion: The 4 h time-point after an oral fat load during a FTT was the most representative measurement of TGs. The highest standardized mean difference of TGs was found after a meal containing 70-79g of fat. The relevance of these two key parameters determined in healthy subjects should be considered for further developments of an oral FFT for clinical purposes.
    Current Vascular Pharmacology 04/2011; 9(3):271-280. · 2.91 Impact Factor
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    ABSTRACT: Triglycerides (TGs) are measured in studies evaluating changes in non-fasting lipid profiles after a fat tolerance test (FTT); however, the optimal timing for TG measurements after the oral fat load is unclear. The aim of this study was to evaluate how non-fasting TG levels vary after an oral FTT in healthy subjects. This meta-analysis included 113 studies with >5 participants of Caucasian race that were indexed in PubMed from its inception through March 2010, using the search term "postprandial lipemia". We only included studies that provided mean values and standard deviation (SD) (or standard error of the mean) for TG measurements at baseline (=fasting) and for at least one other time-point. Exclusion criteria included uncommon sampling time-points after the FTT, baseline TGs≥2.0 mmol/L (≥177mg/dl), and a body mass index ≥30kg/m(2). All studies combined, weighted mean±SD TG values in mmol/L were 1.25±0.32 fasting, 1.82±0.40 at 2 h, 2.31±0.62 at 4 h, 1.87±0.63 at 6 h, and 1.69±0.80 at 8 h. After stratifying studies based on fat quantity in the test meal (<40, ≥40-<50, ≥50-<60, ≥60-<70, ≥70-<80, ≥80-<90, ≥90-<100, ≥100-<110, ≥110-120, ≥120 g), the highest standardized mean difference in TG levels from fasting levels was found in those having an oral fat load of ≥70 g and <80 g, and at 4 h (difference=1.74 mmol/L; p<0.001). The 4 h time-point after an oral fat load during a FTT was the most representative measurement of TGs. The highest standardized mean difference of TGs was found after a meal containing 70-79g of fat. The relevance of these two key parameters determined in healthy subjects should be considered for further developments of an oral FFT for clinical purposes.
    Current Vascular Pharmacology 02/2011; 9(3):271-80. · 2.91 Impact Factor

Publication Stats

331 Citations
180.21 Total Impact Points

Institutions

  • 2013
    • Aghia Sophia Children’s Hospital
      Athínai, Attica, Greece
  • 2007–2012
    • Onassis Cardiac Surgery Center
      • Department of Cardiology
      Kallithea, Attica, Greece
  • 2009
    • Health Centre of Vyronas
      Athínai, Attica, Greece
    • Thriasio General Hospital of Elefsina
      Lepsina, Attica, Greece