ABSTRACT: BACKGROUND: This study evaluated the relationships between capsular characteristics and recurrence of parotid pleomorphic adenomas. METHODS: The pathological slides and clinical data of 110 patients that underwent superficial parotidectomy for pleomorphic adenoma in the parotid gland were reviewed retrospectively. The recurrent and non-recurrent groups comprised 10 and 100 patients, respectively. The two groups were compared with regard to their clinicopathological features, including the capsular characteristics. RESULTS: Satellite nodules were observed in six of the 10 recurrent group patients (60.0%) but in only 10 of the 100 non-recurrent group patients (10.0%) (P = 0.001). Five of the recurrent group subjects (50%), but only 11 of the 100 non-recurrent group subjects (11.0%), had positive resection margins (P = 0.006). Perioperative rupture of the tumor was observed in three recurrent group subjects (30%), but in only four of the non-recurrent group subjects (4.0%) (P = 0.016). Multivariate analyses showed that the risk of recurrence was more than fivefold higher when satellite nodules were present (P = 0.010) and more than 14-fold higher when the tumor had ruptured (P = 0.001). CONCLUSIONS: Satellite nodules and tumor rupture increase the risk of recurrence in patients with pleomorphic adenomas treated by superficial parotidectomy. J. Surg. Oncol © 2012 Wiley Periodicals, Inc.
Journal of Surgical Oncology 06/2012; · 2.10 Impact Factor