Soghrat Faghihzadeh

Zanjan University of Medical Sciences, Zenjān, Zanjan, Iran

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Publications (81)111 Total impact

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    ABSTRACT: Background: To estimate and compare prevalence of overweight and obesity among adult people across the 22 districts of Tehran in 2011. Methods: This was a cross-sectional study using data on 47,406 women and 47,525 men aged≥ 15 years from a large population-based survey (Urban HEART-2). Age-standardized prevalence (ASP) of overweight (25≤BMI<30) and obesity (BMI≥30) were estimated for the Tehran's districts. Pear-son Chi2 tests and logistic regression were used to examine any significant differences in prevalence of these disorders across sociodemographic groups. Results: ASPs of overweight were 36.5% and 32.0 % among men and women, respectively (p<0.001). These figures for obesity were 10.7% and 15.3% among men and women, respectively (p<0.001). Crude prevalence of overweight and obesity rose with age up to the age of 54 years and decreased thereafter. Across education groups, the lowest prevalence of overweight/obesity was seen among most educated people. The results showed that being young, single and student were associated with lower odds of overweight/obesity. Conclusion: This study showed a high prevalence of overweight and obesity among adult in Teh-ran. There were significant associations between sociodemographic characteristics and prevalence of overweight/obesity among adults in Tehran. The results of this study might be used in identifying high risk groups of overweight and obesity in Tehran.
    Medical journal of the Islamic Republic of Iran 01/2015; 29:178.
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    ABSTRACT: Abstract Objective: The main objective of this study was to compare changes in the mental health status of the residents of Tehran from 1999 till 2011. Materials and Methods: This study was an overview of two cross-sectional, descriptive researches that were performed in 1998 and 2011. Samples of these two studies were recruited by regular randomized cluster sampling. In both studies, the General Health Questionnaire (GHQ-28) was used to assess mental health status of general population. Results: The results showed that 21.5% of participants in the 1998 survey suffered from mental disorders (27% women and 14.9% men). In 2011, this figure increased to 39.6% (37.4% of men and 43.1% of women). Prevalence of mental disorders increased from 1998 until 2011 by about 1.8 fold (1.6 fold for women and 2.5 fold for men). In both studies, the risk of mental disorders increased with increasing age, unemployment, illiteracy and divorced or widowed individual. Anxiety symptoms were more prevalent in both studies as compared to somatization, depression, and social dysfunction scales. Conclusion: The dramatic increases of mental disorders during 12 years indicated that policy-makers should give greater importance to prevention and promotion of mental disorders for Tehran residents. Keywords: Mental health change, National health and disease project, Urban equality project 2, Tehran
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    ABSTRACT: Abstract Background and Objective: Findings represent the role of social stress in aging, disease and mortality of individuals. Since the body responses to environmental stress by anxiety behaviors, in this study we compared the effects of "food restriction", "food deprivation" and "social inequality" on anxiety-like behaviors. Materials and Methods: In this study, 48 male rats were divided into 6 groups including “control”, “food restriction; 40% reduction of food intake; being able to sense other’s feeding (inequality)”, “food restriction keeping in isolated place (without inequality)”, “intermittent food restriction” , “ food deprivation ; 70% reduction in food intake; being able to sense other’s feeding (inequality)”, and “food deprivation keeping in isolated place (without inequality)”. Different environmental stresses were applied during three weeks. At the end of stress period, anxiety behavior was measured by elevated plus maze ( EPM) test. Results and Conclusion: The duration and frequency of open arm entries in food deprivation groups had a significant increase and in food restriction groups had a significant decrease as compared to the control group. Combination of increasing activity of the animals with anxiety during dietary restriction along with food inequality represent the effort conditions of animals for improvement. Food deprivation reduces activity, especially when is combined with the feeling of inequality that can be considered as the probable role of social inequality in manifestation of a “learned helplessness” situation. Keywords: Food restriction, Food deprivation, Social inequality, Anxiety
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    ABSTRACT: This study aimed to assess sexual functioning among women with polycystic ovary syndrome (PCOS) in Iran.
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    ABSTRACT: This clinical trial investigated the ability of concurrent speech segregation in hearing impaired children. The auditory behavioral responses and auditory late responses (ALRs) were compared between test and control groups prior to vowel auditory training and after 3 and 6 months of vowel auditory training to find the effects of bottom-up training on concurrent speech segregation in hearing impaired children.
    The Annals of otology, rhinology, and laryngology 06/2014; DOI:10.1177/0003489414540604 · 1.05 Impact Factor
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    ABSTRACT: Neuronal firing synchronization is critical for recording auditory responses from the brainstem. Recent studies have shown that both click and/da/synthetic syllable (speech) stimuli perform well in evoking neuronal synchronization at the brainstem level. In the present study, brainstem responses to click and speech stimuli were compared between children with learning problems (LP) and those with normal learning (NL) abilities. The study included 49 children with LP and 34 children with NL. Auditory brainstem response (ABR) to 100-μs click stimulus and speech ABR (sABR) to/da/40-ms stimulus were tested in these children. Wave latencies III, V, and Vn and inter-peak latency (IPL) V-Vn in click ABR and wave latencies I, V, and A and IPL V-A in sABR were significantly longer in children with LP than children with NL. Except IPL of I-III, a significant positive correlation was observed between click ABR and sABR wave latencies and IPLs in children with NL; this correlation was weaker or not observed in children with LP. In this regard, the difference between correlation coefficients of wave latencies I, III, and V and IPLs I-V and V-Vn/V-A was significant in the two groups. Deficits in auditory processing timing in children with LP may have probably affected ABR for both click and speech stimuli. This finding emphasizes the possibility of shared connections between processing timing for speech and non-speech stimuli in auditory brainstem pathways. Weak or no correlation between click and speech ABR parameters in children with LP may have a clinical relevance and may be effectively used for objective diagnoses after confirming its sufficient sensitivity and specificity and demonstrating its acceptable validity with more scientific evidence.
    Hearing research 05/2014; DOI:10.1016/j.heares.2014.04.009 · 2.85 Impact Factor
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    Zinab Heidari, Saeideh Ziaei, Soghrat Faghihzadeh
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    ABSTRACT: Background: Osteoporosis is a prevalent disease related to menopause, and causes an increasing health problem. Objectives: Our aim was to compare the effects of conventional estrogen replacement therapy and tibolone on the bone mineral density (BMD) and bone turn over in postmenopausal women. Patients and Methods: A total of 150 healthy non-surgical postmenopausal women in Iran were enrolled in a randomized controlled clinical trial. Fifty women received 2.5 mg tibolone plus one calcium + D tablet (500 mg Ca and 200 IU vitamin D) daily; 50 women received 0.625 mg conjugated equine estrogen and 2.5 mg medroxy progesterone acetate (CEE/MPA) plus one calcium + D tablet daily; 50 women received only one calcium + D tablet and served as a control group. Bone densitometry (DAX) of the lumbar spine and the proximal femoral neck and also bone turnover markers (serum alkaline phosphates (ALP) and urine Ca/Cr ratio) measured at baseline and after the nine months of entering into the study. Results: After the treatments, ALP reduced significantly in the CEE/MPA and tibolone groups (P = 0.02, P = 0.002), but increased in the control group (P = 0.03) in comparison with the baseline. After the treatments with respect to femoral BMD, significantly increase occurred only in the tibolone group in comparison with the baseline (0.95 ± 0.13, 0.97 ± 0.12, P = 0.004). Conclusions: Tibolone may be considered as an alternative for preventing of osteoporosis in postmenopausal women. Implication for health policy/practice/research/medical education: Osteoporosis is a common disease associated with ageing and menopause, and is becoming an increasing health and socio-economic problem. In this study, our aim was to compare the effects of conventional estrogen replacement therapy and tibolone on the bone mineral density (BMD) and bone turnover in postmenopausal women.
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    ABSTRACT: Hypertension is an important public-health challenge worldwide. The prevalence of hypertension greatly varies across countries. The aim of this study was to estimate the prevalence of self-reported hypertension and to determine related factors in a large random sample of Tehran population in 2011. In this cross sectional study, 69173 individuals aged 25-64 years were selected using multistage cluster random sampling method. All participants were interviewed by trained personnel using standard questionnaires. Weighted prevalence and incidence rates were calculated and principle component analysis (PCA) was used to construct wealth index. Chi-square and odds ratio were used to assess associations in univariate analysis. Logistic Regression model was used in multivariate analysis. The prevalence of self-reported hypertension was 5.27% in total, 3.83% in men and 6.64% in women (p< 0.001). The annual incidence rate of self-reported hypertension was 6.87 per 1000; 5.26 in men and 8.43 in women (p< 0.001), obviously varied across various districts. In multivariate analysis, age, sex (woman), marital status (single), obesity and smoking were positively associated with prevalence of self-reported hypertension. Education level was negatively associated to hypertension. On the other hand, wealth status was not associated to self-reported hypertension. Our study findings highlighted low awareness rates of hypertension among Tehran adults especially in men and younger people. Hence, we recommend public health strategies to improve health education programs. Moreover, programs to develop the surveillance system and screening programs to early detection of undiagnosed cases are urgently needed particularly in high risk population subgroups.
    Medical journal of the Islamic Republic of Iran 01/2014; 28:105.
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    ABSTRACT: Understanding the factors that contribute to health-related quality of life (HRQOL) is critical for developing the most appropriate interventions for improving or maintaining the HRQOL in polycystic ovary syndrome (PCOS) patients. This study sought to determine the most significant predictors of the HRQOL in patients with PCOS. This was a cross-sectional study of 300 women with PCOS that was carried out in Kashan, Iran. A sample of women with PCOS was entered into the study and completed the following questionnaires: the Hospital Anxiety and Depression Scale, the Body Image Concern Inventory (BICI), the Rosenberg's Self-Esteem Scale score, the modified polycystic ovary syndrome health-related quality of life questionnaire, the Female Sexual Function Index. Both direct and indirect relationships among clinical severity, psychological status, self-esteem, body image, and sexual function as independent predictors of HRQOL were examined using structural equation modeling (SEM) analysis. By using the SEM, we simultaneously test a number of possible hypotheses concerning the interrelations among the predictors of HRQOL in PCOS patients. In relation with severity of PCOS, reproductive history and menstrual status explained a high proportion of the variance of clinical variables (factor loading 0.37 and 0.34, respectively). The highest effect on HRQL was exerted by indirect effect of clinical factor (β = 0.90), self-esteem (β = 1.12), body image (β = 1.06), and sexual function (β = 0.26) that influenced negatively HRQOL. The infertility and menstrual domains were the most affected areas of HRQOL. In relation with sexual dysfunction, the most affected domains were desire and arousal. The highest effect of PCOS symptoms on HRQOL impairment among patients was exerted by self-esteem, body image, and sexual dysfunction. With regard to HRQOL in clinical routine, we conclude these mediating factors should be taken into consideration and adequately treated if present. Bazarganipour F, Ziaei S, Montazeri A, Foroozanfard F, Kazemnejad A, and Faghihzadeh S. Health related quality of life in patients with polycystic ovary syndrome (PCOS): A model-based study of predictive factors. J Sex Med **;**:**-**.
    Journal of Sexual Medicine 12/2013; 11(4). DOI:10.1111/jsm.12405 · 3.15 Impact Factor
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    ABSTRACT: Background Current evidence consistently confirm inequalities in health status among socioeconomic none, gender,ethnicity, geographical area and other social determinants of health (SDH), which adversely influence health ofthe population. SDH refer to a wide range of factors not limited to social component, but also involve economic, cultural,educational, political or environmental problems. Measuring inequalities, improving daily living conditions, andtackling inequitable distribution of resources are highly recommended by international SDH commissioners in recentyears to ‘close the gaps within a generation’. To measure inequalities in socio-economic determinants and core healthindicators in Tehran, the second round of Urban Health Equity Assessment and Response Tool (Urban HEART-2)was conducted in November 2011, within the main framework of WHO Centre for Health Development (Kobe Centre). MethodFor ‘assessment’ part of the project, 65 indicators in six policy domains namely ‘physical and infrastructure’,‘human and social’, ‘economic’, ‘governance’, ‘health and nutrition’, and also ‘cultural’ domain were targetedeither through a population based survey or using routine system. Survey was conducted in a multistage random sampling,disaggregated to 22 districts and 368 neighborhoods of Tehran, where data of almost 35000 households(118000 individuals) were collected. For ‘response’ part of the project, widespread community based development(CBD) projects were organized in all 368 neighborhoods, which are being undertaken throughout 2013.ConclusionFollowing the first round of Urban HEART project in 2008, the second round was conducted to trackchanges over time, to institutionalize inequality assessment within the local government, to build up community participationin ‘assessment’ and ‘response’ parts of the project, and to implement appropriate and evidence-based actionsto reduce health inequalities within all neighborhoods of Tehran.
    Medical journal of the Islamic Republic of Iran 11/2013; 27(4):236-248.
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    ABSTRACT: Hearing capability plays a principal role on human's communication. Noise-induced hearing loss (NIHL) caused by exposure to high noise levels is a serious socio-economic problem in modern societies. NIHL can either be reversible, resulting in a temporary threshold shifts (TTS) or irreversible, resulting in a permanent threshold shifts (PTS). PTS is often confirmed in the time span of between 2 - 6 weeks. NIHL may be prevented by avoidance of excessive amounts of noise or reducing the sound energy entering the inner ear using hearing protective devices. However, there are some conditions that such prevention is not possible such as noise exceeding the protective capabilities of the hearing protection device, working in military or the person does not tolerate the protection device. Thus the protective agent for preventing NIHL would be useful. Free radical molecules and consequence oxidative stress have been shown to play a significant role in noise-induced hearing loss. Silymarin is an antioxidant flavonoid complex derived from the herb milk thistle has ability to mitigating the oxidative stress, scavenge free radicals. In the current study, we aimed to evaluate the protective effect of silymarin on noise induced hearing loss in guinea pig by auditory brain stem response. Twenty guinea pigs randomly divided into 2 groups. The animals in the experimental group were intraperitoneally injected with 100 mg/kg/day silymarin dissolved in propylene glycol for 6 consecutive days. The control subjects were intraperitoneally injected with propylene glycol for 6 consecutive days. All animals were exposed to 4 kHz octave band noise at 120 dB SPL for 6 hours. Auditory brainstem responses (ABRs) at frequencies of 2, 4, 6, 8, 12, 16 and 20 kHz were precisely recorded before intervention and then on intervals of 0, 3, 10 and 15 days after noise exposure. Data were analyzed using repeated measures ANOVA. Threshold shifts for the experimental group at all frequencies immediately, 3, 10 and 15 days after noise exposure were significantly reduced compared to the control group (P < 0.01). The findings indicate a protective effect of silymarin on temporary and permanent noise-induced hearing loss.
    11/2013; 15(11):e8890. DOI:10.5812/ircmj.8890
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    ABSTRACT: Background: Most previous research has focused on polycystic ovary syndrome (PCOS) characteristics and their association with psychological disorders, such as anxiety and depression. Objective: In the present study, our aim was to study whether PCOS characteristics are associated with several aspects of psychological well-being namely self-esteem and body satisfaction. Materials and Methods: This was a cross-sectional study of 300 women with PCOS that was carried out in Kashan, Iran. Main outcome measures were the Body Image Concern Inventory (BICI) and the Rosenberg’s Self-Esteem Scale and clinical information of PCOS. Major clinical PCOS features including obesity (BMI), excessive body hair (hirsutism score), acne, menstrual cycle disturbances and infertility. Results: The findings of regression analysis indicated that infertile women had lower levels of self-esteem (=-0.11, p=0.049) and poorer body satisfaction (=0.121, p=0.036) compared with PCOS women without infertility. Furthermore, hirsute women experienced poorer self-esteem than women without hirsutism (=-0.124, p=0.032). Women with menstrual irregularities had higher body dissatisfaction (=0.159, p=0.005). Moreover, women with higher body mass index scores had poorer body satisfaction (=0.151, p=0.009) but were not associated with self-esteem. Conclusion: The emotional well-being of the patients presenting with the syndrome needs to be recognized more fully, particularly in relation to the low self-esteem, poor body image, and struggles with weight, menstrual irregularities, hirsutism and infertility. The results of this study raise implications for clinical practice and suggest that a multidisciplinary approach to the management of women with PCOS. This article extracted from Ph.D. thesis. (Fatemeh Bazarganipour)
    Iranian Journal of Reproductive Medicine 10/2013; 11(10):829-36. · 0.19 Impact Factor
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    ABSTRACT: Various approaches have been offered to alleviate chronic pain resulting from spinal cord injuries (SCIs). Application of herbs and natural products, with potentially lower adverse effects, to cure diseases has been recommended in both traditional and modern medicines. Here, the effect of crocin on chronic pain induced by spinal cord contusion was investigated in an animal model. Female Wistar rats were randomly divided into five groups (5 rats in each); three groups were contused at the L1 level. One group was treated with crocin (150mg/kg) two weeks after spinal cord injury; the second group, control, was treated with vehicle only; and the third group was treated with ketoprofen. Two normal groups were also considered with or without crocin treatment. The mechanical behavioral test, the locomotor recovery test and the thermal behavioral test were applied weekly to evaluate the injury and recovery of rats. Significant improvements (p<0.05) in mechanical behavioral and locomotor recovery tests were seen in the rats treated with crocin. Thermal behavioral test did not show any significant changes due to crocin treatment. Plasma concentration of calcitonin-gene related peptide (CGRP) changed from 780.2±2.3 to 1140.3±4.5pg/ml due to SCI and reached 789.1±2.7pg/ml after crocin treatment. These changes were significant at the level of p<0.05. The present study shows the beneficial effects of crocin treatment on chronic pain induced by SCI, through decreasing CGRP as an important mediator of inflammation and pain.
    Phytomedicine: international journal of phytotherapy and phytopharmacology 09/2013; 21(1). DOI:10.1016/j.phymed.2013.07.013 · 2.88 Impact Factor
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    ABSTRACT: Background: A preliminary report indicated that the Iranian version of modified polycystic ovary syndrome health-related quality of life questionnaire (MPCOSQ) is a valid measure of health-related quality of life (HRQOL) in PCOS patients. Accordingly, the Iranian version of MPCOSQ was subjected to further psychometric analyses among a different sample of patients with PCOS. Objective: To examine discriminant and convergent validity of the Iranian version of MPCOSQ. Materials and Methods: This was a cross sectional study of 200 women with PCOS that was carried out in two private gynecology clinics in Kashan, Iran. Discriminant validity was assessed using the known groups comparison. Convergent validity was evaluated by assessing the correlation between similar content on the MPCOSQ and the SF-36. Results: The mean scores for the MPCOSQ showed that women rated lowest on the infertility and menstrual subscales indicating worst health in these dimensions. The results from the SF-36 questionnaire indicated that emotional and vitality domains were the areas of poorest health. Known groups comparison showed that the MPCOSQ differentiated well between sub-groups of women who differed in PCOS specific symptoms, lending support to its discriminant validity. Convergent validity was assessed and as expected a good positive correlation was found between related subscales of the two instruments. Conclusion: The MPCOSQ has now been extensively tested in Iran and can be considered for using as an outcome measure in future outcome studies in this population. This study extracted from Ph.D. thesis. (Fatemeh Bazarganipour)
    Iranian Journal of Reproductive Medicine 09/2013; 11(9):753-60. · 0.19 Impact Factor
  • Leila Nuri, Nastaran Ghotbi, Soghrat Faghihzadeh
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    ABSTRACT: Objectives: Muscle flexibility is an important component of injury prevention in athletes. Active warm-up, passive warm-up and static stretching are different methods for increasing flexibility. Little clinical evidence is available regarding which of these methods has a greater role in increasing flexibility. This study was performed to compare acute effects of the above methods on the flexibility of the plantar flexor muscles of professional female taekwondo athletes. Methods: Female professional taekwondo athletes were randomly classified into three intervention protocol groups [active warm-up, passive warm-up, or static stretching, respectively]. Passive and active range of motion [ROM] was measured using a universal goniometer before and immediately after performing each of the designated flexibility protocols. Results: Thirty female athletes participated, providing 10 subjects for each group. There were no differences in age or body mass index between groups. The static-stretching protocol significantly increased active [p = 0.001] and passive [p = 0.001] ROM. The active warm-up protocol did not change either the active or passive ROM [p > 0.05]. The passive warm up protocol increased only the active ROM [p = 0.04]. Post hoc testing showed a significant difference not only between static stretching and active warm-up groups [p = 0.000], but also between static stretching and passive warm-up groups [p = 0.000]. There was no significant difference between the passive and active warm-up groups [p > 0.05]. Conclusions: Static stretching only protocol increased flexibility more than active and passive warm-up only protocols.
    Journal of Musculoskeletal Pain 09/2013; DOI:10.3109/10582452.2013.827771 · 0.32 Impact Factor
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    ABSTRACT: AimThe aim of the present study was to estimate the prevalence of mood disorders and examine a range of predictors for psychological well-being among Iranian women with polycystic ovary syndrome (PCOS).Materials and methods: A cross-sectional study was undertaken to ascertain the factors related to psychological distress in PCOS patients in Kashan, Iran. Psychological distress was measured using the Hospital Anxiety and Depression Scale (HADS). In addition we assessed quality of life using the Short Form Health Survey (SF-36). Socio-demographic details and clinical information of PCOS including obesity (body mass index), excessive body hair (hirsutism score), acne, menstrual cycle disturbances, infertility and endocrine profile also were recorded for each patient. In all 300 women with PCOS were entered into the study. Of these 32% (n =96) showed elevated HADS anxiety while depression was high in 5% (n =15). Quality of life was significantly impaired in women with anxiety (P <0.05), and depression (P <0.001) and in particular, in women with coexistence anxiety and depression (P <0.001) compared with unaffected participants. Compared with the non-depressed PCOS patients, the depressed women had significantly higher menstrual irregularities (P = 0.008). Moreover, we found significant difference in FAI level between the depressed and non depressed (p = 0.05), the anxious and non anxious patients (p < 0.001) compare to non affected PCOS women. The high prevalence of depression and anxiety in this population suggests that initial evaluation of all women with PCOS should also include assessment of mental health disorders. The clinician should further pay attention to background of their patients especially in view of the factors influencing psychological well-being.
    Health and Quality of Life Outcomes 08/2013; 11(1):141. DOI:10.1186/1477-7525-11-141 · 2.10 Impact Factor
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    ABSTRACT: To determine association between health-related quality of life (HRQOL) and psychosexual variables in patients with polycystic ovary syndrome (PCOS). Cross-sectional study. Two private gynecology clinics. A sample of 300 women with PCOS were entered into the study and were subdivided into three groups: hyperandrogenism (HA) and PCO morphology; menstrual dysfunction and PCO morphology; menstrual dysfunction and HA and/or PCO morphology. Then each patient completed the following questionnaires: the Hospital Anxiety and Depression Scale, the Body Image Concern Inventory, the Rosenberg Self-Esteem Scale, the Short-Form Health Survey, and the Female Sexual Function Index. None. Both direct and indirect relationships among clinical symptoms, psychologic status, self-esteem, body image, and sexual function as independent predictors of HRQOL were examined with the use of structural equation modeling analysis. The clinical variables and psychologic distress had the strongest indirect relationships with HRQOL in the HA phenotype. The highest effect of PCOS symptoms on HRQOL impairment in patients with menstrual irregularities along with HA and patients with menstrual irregularities along with polycystic ovaries was exerted by clinical variables, poor perception of self-worth, negative body image, and sexual dysfunction. In patients with various phenotypes of PCOS, the effects of mediating variables on HRQOL are different. In patients with PCOS, the findings suggest that mediating factors, especially psychologic distress, self-esteem, body image, and sexual function, play an important role and should be taken into consideration and adequately treated if present.
    Fertility and sterility 07/2013; DOI:10.1016/j.fertnstert.2013.06.043 · 4.30 Impact Factor
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    ABSTRACT: Background: Polycystic ovarian syndrome (PCOS) has been shown to cause a reduction in Health-related quality of life (HRQOL). Objective: This study examines the extent of different clinical symptoms in PCOS patients on HRQOL. Materials and Methods: A cross-sectional study was undertaken to ascertain the factors related to HRQOL in 200 PCOS patients in Kashan, Iran. Main outcome measures were modified polycystic ovarian syndrome questionnaire (MPCOSQ) and clinical information of PCOS. Major clinical PCOS features including obesity (BMI), excessive body hair (hirsutism score), acne, menstrual cycle disturbances and infertility. Results: Findings showed that the most common HRQOL concern was menstrual irregularities and infertility, followed in descending order by hirsutism, weight, emotion, and acne. Multivariate analysis revealed the menstrual irregularities as a significant predictor of menstruation (p=0.005), emotion (p=0.02) and infertility (p=0.02) subscales of the MPCOSQ. Having of infertility, predicted scores on the infertility subscale (p<0.0001). Hirsutism score was a significant predictor of hirsutism (p<0.0001) and emotion (p<0.0001) subscales. Weight subscale concerns was predicted by BMI (p<0.0001), also, acne was found to be predicted score of acne subscale (p<0.0001). Conclusion: Worsened HRQOL in women with PCOS was related to more menstrual irregularities and infertility than to obesity. The finding suggests a potential for poorer compliance with weight management protocols among affected PCOS patients.
    Iranian Journal of Reproductive Medicine 05/2013; 11(5):371-8. · 0.19 Impact Factor
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    ABSTRACT: Objective: Various approaches have been offered for resolution of pain resulting from spinal cord injuries. One approach is the use of herbal and natural products. In the present research, as a preliminary study, we investigate the effect of crocin on chronic pain induced by contusion in the rat spinal cord (SCI). Methods: We randomly divided female Wistar rats into five groups. Groups I and II were contused at the L1 level and immediately treated with crocin (50 mg/kg). These groups were sacrificed after 2 hours and 1 week, respectively. The remaining three groups consisted of group III (control group), group IV (treated with crocin and no contusion), and group V (the contused group that underwent no treatment). Groups III-V were sacrificed after one week. The mechanical behavioral test that used Von Frey hairs; the thermal behavioral test that used a hot-plate and the locomotor recovery test with Basso, Beattie and Bresnahn (BBB) scoring were conducted daily to evaluate the extent of injury and recovery of the rats. The calcitonin-gene related peptide (CGRP) was determined in the animals' plasma by the ELISA kit. Results: The results showed a significant increase in plasma CGRP of contused rats that significantly reduced following crocin treatment. The behavioral tests were not changed significantly due to this treatment. Conclusion: The present study shows the beneficial effects of crocin treatment that may occur by decreasing CGRP on chronic pain induced by SCI. This project is continuing using higher dose of crocin for longer time.
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    ABSTRACT: Abstract Context: Sulfur mustard (SM), with an old manufacturing history still remains as potential threat due to easy production and extensive effects. Objectives: Increasing studies on SM indicates the interest of researchers to this subject. Almost all human body organs are at risk for complications of SM. This study offers organ-by-organ information on the effects of SM in animals and humans. Methods: The data sources were literature reviews since 1919 as well as our studies during the Iraq-Iran war. The search items were SM and its all other nomenclatures in relation to, in vivo, in vitro, humans, animals, eye, ocular, ophthalmic, lungs, pulmonary, skin, cutaneous, organs and systemic. Amongst more than 1890 SM-related articles, 257 more relevant clinicopathologic papers were selected for this review. Results: SM induces a vast range of damages in nearly all organs. Acute SM intoxication warrants immediate approach. Among chronic lesions, delayed keratitis and blindness, bronchiolitis obliterans and respiratory distress, skin pruritus, dryness and cancers are the most commonly observed clinical sequelae. Conclusion: Ocular involvements in a number of patients progress toward a severe, rapid onset form of keratitis. Progressive deterioration of respiratory tract leads to "mustard lung". Skin problems continue as chronic frustrating pruritus on old scars with susceptibility to skin cancers. Due to the multiple acute and chronic morbidities created by SM exposure, uses of multiple drugs by several routes of administrations are warranted.
    Cutaneous and Ocular Toxicology 04/2013; 32(4). DOI:10.3109/15569527.2013.781615 · 0.92 Impact Factor

Publication Stats

386 Citations
111.00 Total Impact Points

Institutions

  • 2012–2014
    • Zanjan University of Medical Sciences
      • • Department of Statistics and Social Medicine
      • • Faculty of Medicine
      Zenjān, Zanjan, Iran
  • 2005–2014
    • Tarbiat Modares University
      • • Department of Biostatistics
      • • Faculty of Medical Sciences
      • • Department of Immunology
      Teheran, Tehrān, Iran
  • 2013
    • University of Zanjan
      Zenjān, Zanjan, Iran
  • 2008–2011
    • Shahed University
      • Immunoregulation Research Center (IRRC)
      Teheran, Tehrān, Iran