Publications (2)1.63 Total impact

  • F. Huang · M.H. Lu · H.Y. Gong · Z.P. Xiong ·
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    ABSTRACT: We examined the expression of peripheral blood natural killer T (NKT) cells in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients and predicted its efficacy after pegylated interferon a-2a (Peg-INFα-2a) therapy. Sixty-three cases of HbeAg-positive CHB inpatients and outpatients, treated in the Third Xiangya Hospital of Central South University from January to December 2010, were administrated Peg-INFα-2a 18 myriad international unit intramuscularly once per week for 48 weeks. The number of peripheral NKT cells, 5 quantitative indicators of hepatitis B, and hepatitis B virus DNA capacity were detected at each time point. Forty-eight weeks after Peg-INFα-2a treatment, 26 HBeAg-positive CHB patients exhibited significant effects, 21 cases exhibited effects, and 16 cases showed no effects. The ratio of peripheral blood NKT cells in T lymphocytes before and 4, 8, and 12 weeks after treatment in the significant effect group was significantly increased compared to the effect group and no effect group (P < 0.01); at the 48th week of treatment and 24 weeks after the drug was withdrawn, NKT cell expression in the significant effect group was significantly higher than that in the effect group (t = 32.0, P < 0.01; t = 27.6, P < 0.01, respectively). A total of 27 patients showed HBeAg seroconversion until the 24th week after drug withdrawal. During treatment with Peg-INFα- 2a in HBeAg-positive CHB patients, expression of peripheral blood NKT cells could be used to predict efficacy.
    Genetics and molecular research: GMR 05/2015; 14(2):4932-4938. DOI:10.4238/2015.May.11.26 · 0.78 Impact Factor
  • F Huang · H Y Gong · M H Lu ·
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    ABSTRACT: Pulmonary sparganosis mansoni is uncommon in general clinical practice, but prevalent in endemic foci. Pulmonary sparganosis mansoni shares some clinical and radiologic similarities that mimic other common pulmonary pathogens. Delayed diagnosis of pulmonary sparganosis mansoni can pose a significant hazard to the patient. Indeed, a history of ingesting uncooked stone cracks in endemic areas is strongly suggestive of the possibility of pulmonary sparganosis mansoni. We report a case of a 43-year-old male peasant infested with pulmonary sparganosis mansoni who had been misdiagnosed with pulmonary tuberculosis.
    Tropical biomedicine 06/2012; 29(2):220-3. · 0.85 Impact Factor