Fatemeh Rezaei

Publications (2)8.02 Total impact

• Article: Solid phase extraction as a cleanup step before microextraction of diclofenac and mefenamic acid using nanostructured solvent.

  Fatemeh Rezaei, Yadollah Yamini, Morteza Moradi, Behnam Ebrahimpour
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  ABSTRACT: A new pretreatment method, solid-phase extraction combined with supramolecular solvents, was proposed for the first time for extraction of diclofenac (DIC) and mefenamic acid (MEF) from urine and water samples. Supramolecular solvent (SUPRAS) is a nano-structured liquid, generated from the amphiphiles through a sequential self-assembly process occurring on two scales, molecular and nano. SUPRAS tested were generated from solutions of reverse micelles of decanoic acid (DeA) in tetrahydrofuran (THF) by addition of water, which acted as the coacervating agent. In the present study, due to matrix effect, drugs were first extracted from the samples by SPE. The extracted analytes were then eluted from the sorbent with THF, and the eluate was subjected to SUPRAS formation (SUPRASF) process. Finally, the analytes in the SUPRAS were separated and determined by HPLC-UV. Several parameters affecting the SPE-SUPRASF process were investigated and optimized. The new method provides enrichment factors in the range of 431-489 for MEF and DIC, respectively. Calibration plots are linear in the range of 2-200 μgL(-1) for MEF and 1-200 μgL(-1) for DIC, with correlation of determination (r(2)) ranging from 0.996 to 0.999. The method was successfully applied for extraction and determination of analytes in urine and water samples and relative recoveries of the studied compounds were obtained in the range of 90.4-103.8%.
  Talanta 02/2013; 105C:173-178. · 3.79 Impact Factor
• Article: Development of a new and environment friendly hollow fiber-supported liquid phase microextraction using vesicular aggregate-based supramolecular solvent.

  Morteza Moradi, Yadollah Yamini, Fatemeh Rezaei, Elham Tahmasebi, Ali Esrafili
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  ABSTRACT: Hollow fiber-based liquid phase microextraction (HF-LPME) using conventional solvents is limited by their relative instability and high volatility. The use of supramolecular solvents as a liquid membrane phase could overcome these inconveniences due to their negligible vapour pressure and high viscosity. In the present study, a novel and highly flexible method was developed based on supramolecular solvents constructed of vesicles of decanoic acid, which were used for the first time as a solvent in HF-LPME. This solvent is produced from the coacervation of decanoic acid aqueous vesicles by the action of tetrabutylammonium (Bu(4)N(+)). In this work, halogenated anilines as model compounds were extracted from water samples into a supramolecular solvent impregnated in the pores and also filled inside the porous polypropylene hollow fiber membrane. The extracted anilines were separated and determined by high-performance liquid chromatography. The technique requires minimal sample preparation time and toxic organic solvent consumption, and provides a significant advantage over conventional analytical methods. The important parameters influencing the extraction efficiency were studied and optimized utilizing two different optimization methods: one variable at a time and the Box-Behnken design. Under the optimum conditions, the preconcentration factors were in the range of 74 to 203. Linearity of the method was obtained in the range of 1.0-100 μg L(-1) with the correlation coefficients of determination (R(2)) ranging from 0.9901 to 0.9986. The limits of detection for the target anilines were 0.5-1.0 μg L(-1). The relative standard deviations varied from 3.9% to 6.0%. The relative recoveries of the three halogenated anilines from water samples at a spiking level of 20.0 μg L(-1) were in the range of 90.4-107.4%.
  The Analyst 06/2012; 137(15):3549-57. · 4.23 Impact Factor