G Esther A Habers

Publications (2)3.94 Total impact

• Article: Design of the muscles in motion study: a randomized controlled trial to evaluate the efficacy and feasibility of an individually tailored home-based exercise training program for children and adolescents with juvenile dermatomyositis.

  Esther A Habers, Marco van Brussel, Anneli C Langbroek-Amersfoort, Annet van Royen-Kerkhof, Tim Takken
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  ABSTRACT: Juvenile dermatomyositis (JDM) is a rare, often chronic, systemic autoimmune disease of childhood, characterized by inflammation of the microvasculature of the skeletal muscle and skin. Prominent clinical features include significant exercise intolerance, muscle weakness, and fatigue. Despite pharmacological improvements, these clinical features continue to affect patients with JDM, even when the disease is in remission. Exercise training is increasingly utilized as a non-pharmacological intervention in the clinical management of (adult) patients with chronic inflammatory conditions; however no randomized controlled trials (RCT) have been performed in JDM. In the current study, the efficacy and feasibility of an exercise training program in patients with JDM will be examined. Subjects (n = 30) will include 8-18 year olds diagnosed with JDM. The intervention consists of an individually tailored 12-weeks home-based exercise training program in which interval training on a treadmill is alternated with strength training during each session. The program is based on previous literature and designed with a defined frequency, intensity, time, and type of exercise (FITT principles). Primary outcome measures include aerobic exercise capacity, isometric muscle strength, and perception of fatigue. The study methodology has been conceived according to the standards of the CONSORT guidelines. The current study will be a multi-center (4 Dutch University Medical Centers) RCT, with the control group also entering the training arm directly after completion of the initial protocol. Randomization is stratified according to age and gender. The current study will provide evidence on the efficacy and feasibility of an individually tailored 12-week home-based exercise training program in youth with JDM. Medical Ethics Committee of the University Medical Center Utrecht, the Netherlands: 11-336; Netherlands Trial Register (NTR): NTR 3184.
  BMC Musculoskeletal Disorders 06/2012; 13:108. · 1.58 Impact Factor
• Article: Near-infrared spectroscopy during exercise and recovery in children with juvenile dermatomyositis.

  G Esther A Habers, Rogier De Knikker, Marco Van Brussel, Erik Hulzebos, Dick F Stegeman, Annet Van Royen, Tim Takken
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  ABSTRACT: Introduction: We hypothesized that microvascular disturbances in muscle tissue play a role in the reduced exercise capacity in juvenile dermatomyositis (JDM). Methods: Children with JDM, children with juvenile idiopathic arthritis (clinical controls), and healthy children performed a maximal incremental cycloergometric test from which normalized concentration changes in oxygenated hemoglobin (Δ[O(2) Hb]) and total hemoglobin (Δ[tHb]) as well as the half-recovery times of both signals were determined from the vastus medialis and vastus lateralis muscles using near-infrared spectroscopy. Results: Children with JDM had lower Δ[tHb] values in the vastus medialis at work rates of 25%, 50%, 75%, and 100% of maximal compared with healthy children; the increase in Δ[tHb] with increasing intensity seen in healthy children was absent in children with JDM. Other outcome measures did not differ by group. Conclusions: The results suggest that children with JDM may experience difficulties in increasing muscle blood volume with more strenuous exercise. Muscle Nerve, 2012.
  Muscle & Nerve 06/2012; · 2.37 Impact Factor