Safak Sahin

Gazi University, Engüri, Ankara, Turkey

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Publications (22)34.39 Total impact

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    ABSTRACT: To determine the prevalence and pattern of androgenetic alopecia in Turkey and to compare the results with different regions. The community-based study was carried out from September 2012 to June 2013 across all the 12 districts of Tokat province of Turkey. Individuals 20-years-old or older were included, and more than two first-degree relatives were excluded. Dermatological examination of all the subjects was performed by dermatologists. The degree of androgenetic alopecia was classified according to the Hamilton-Norwood and Ludwig classifications. Of the 2322 volunteers, 1288(55.46%) were women and 1034(44.53%) were men. Overall mean age was 47.3±15.3 years (range: 20-87 years). Androgenetic alopecia was detected in 740(31.8%) subjects; 247(19.17%) women and 493(47.6%) men. The prevalence of androgenetic alopecia in Turkish society was higher than Asian and African communities; and similar to the rate in European societies hair-loss.
    Journal of the Pakistan Medical Association 08/2015; 65(8):806-809. · 0.40 Impact Factor
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    ABSTRACT: Objective: The aim of this study was to compare the periodontal status in patients with Familial Mediterranean Fever (FMF) and in those without this disease. Method and Materials: 84 subjects clinically diagnosed with FMF and 75 systemically healthy controls, matched by age and gender, were recruited. All FMF patients were on a regular daily colchicine treatment and during attack-free periods. Gingival Index (GI), Plaque Index (PI), probing pocket depth (PD), and clinical attachment level (CAL) were measured in all subjects. To evaluate periodontal disease further, patients were stratified into five groups. Education information and smoking habits were recorded. Results: The FMF patients and healthy controls were comparable for age, gender, and smoking status (P > .05). The FMF patients had significantly higher PI and GI values and lower PD and CAL values than those of the control group (P < .05). However, there was no significant difference among all groups in terms of periodontal disease severity (P > .05). In the FMF-severe periodontitis group, higher PI and GI values were seen (P < .05). However, there was no significant difference between the FMF-severe periodontitis group and the controls with severe periodontitis regarding the PD and CAL values (P > .05). Conclusion: Patients with FMF using colchicine did not manifest higher attachment loss compared to age- and sex-matched systemically healthy controls.
    Quintessence international (Berlin, Germany: 1985) 10/2014; 45(9):743-8. DOI:10.3290/j.qi.a32442 · 0.73 Impact Factor
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    ABSTRACT: Aim Our aim was to evaluate whether there was a relationship between mean platelet volume and myocardial perfusion defect in diabetic patients using myocardial perfusion imaging. Method Forty-four diabetic patients with myocardial perfusion defect (group 1) and 44 diabetic patients without myocardial perfusion defect (group 2), matched for age and gender, were retrospectively examined. Levels of mean platelet volume (MPV) in the two groups were assessed. Results MPV was higher in group 1 than group 2 patients (8.76 ± 0.76 and 8.25 ± 0.78 fl), respectively, p = 0.003). Levels of glucose, triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, haemoglobin (Hb) and glycosylated haemoglobin (HbA1c), and body mass index (BMI) in the two groups were not statistically significantly different. Multivariate logistic regression analyses showed that MPV was the only variable independently associated with myocardial perfusion defects (OR: 2.401, 95% CI: 1.298–4.440, p = 0.013). Conclusion This study showed that higher MPV was associated with myocardial perfusion defects. Higher MPV in diabetic patients was independently related to myocardial perfusion defects and may be an indicator of myocardial ischaemia.
    Cardiovascular journal of Africa 05/2014; 25(3):110-113. DOI:10.5830/CVJA-2014-013 · 0.79 Impact Factor
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    ABSTRACT: Objectives: Our aim was to determine whether there is a relationship between admission gamma-glutamyltransferase (GGT) and subsequent heart failure hospitalizations in patients with acute coronary syndrome. Study design: We selected 123 patients with newly diagnosed acute coronary syndrome of ejection fraction (EF) <45%. Patients were followed 15±10 months, and the relationship between admission GGT level and hospitalization because of heart failure during the follow-up was examined. Results: Twenty-three (18.7%) patients were hospitalized during the follow-up of 15±10 months. Receiver operating characteristic (ROC) curve analysis showed that the cut-off point of admission GGT related to predict hospitalization was 49 IU/L, with a sensitivity of 81.7% and specificity of 65.2%. Increased GGT >49 IU/L on admission, presence of hypertension and hyperlipidemia, left ventricular ejection fraction (LVEF), right ventricular dysfunction, moderate-to-severe mitral regurgitation, alanine aminotransferase level, and antiplatelet agent usage were found to have prognostic significance in univariate Cox proportional hazards analysis. In multivariate Cox proportional-hazards model, increased GGT >49 IU/L on admission (hazard ratio [HR] 2.663, p=0.047), presence of hypertension (HR 4.107, p=0.007), and LVEF (HR 0.911, p=0.002) were found to be independent factors to predict new-onset heart failure requiring hospitalization. Conclusion: Hospitalization in heart failure was associated with increased admission GGT levels. Increased admission GGT level in acute coronary syndrome with heart failure should be monitored closely and treated aggressively.
    Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir 04/2014; 42(3):236-44.
  • S. Senel · S. Sahin · H. Ataseven · I. Yalcin
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    ABSTRACT: Background Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease which is characterized by recurrent attacks of fever and peritonitis, pleuritis, arthritis, or erysipelas-like skin disease.There are very limited study in the literature about mean platelet volume (MPV) levels in FMF patients. Objectives We aimed to investigate levels of mean MPV during attack period and attack free periods in Familial Mediterranean fever (FMF) patients and to compare with healthy controls. Methods The study consisted of 16 FMF patients during an attack, 51 FMF patients in attack-free period and 75 healthy controls. Erythrocyte sedimentation rate, C-reactive protein, white blood cell count, platelet count, and MPV levels were retrospectively recorded from patient files. Results At the end of the study statistical analyses showed that MPV was significantly lower in FMF patients both during attack and attack-free than in healthy controls (p=0.015, p=0.016); however, there was no difference among during attack and attack-free patients (p=0.279). All results were shown in Table 1. Conclusions We found that the MPV levels were significantly lower in the FMF group than in healthy controls. Our results suggest that patients with FMF have not an increased platelet activation. It was conculed that the lower MPV levels were an expected result of secondary thrombocytosis in FMF patients. Disclosure of Interest None Declared
    Annals of the Rheumatic Diseases 01/2014; 71(Suppl 3):708-708. DOI:10.1136/annrheumdis-2012-eular.1230 · 10.38 Impact Factor
  • S. Senel · I. Gul · H. Ataseven · A. U. Uslu · S. Sahin
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    ABSTRACT: Background Familial Mediterranean fever (FMF) is an autoinflammatory disease of obscure pathogenesis with autosomal recessive heredity, which mainly affects people of Mediterranean origin, especially Jewish, Turkish, Armenian and Arabic population. The disease is characterized by recurrent episodes of febrile serositis and manifested primarily as abdominal, chest, and joint pain. Objectives Pericardial involvement in FMF patients has been determined by several researches at different rates, including with or without echocardiographic examination. However, there is no enough data about it yet. The primary aim of this study was to define the frequency of pericardial effusion (PE) in patients with FMF during attack period with echocardiography. Methods The study population was selected from patients admitted to the rheumatology clinic of our center with FMF attack. The FMF diagnosis was made according to Tel–Hashomer criteria. The attack period was ensured with laboratory findings and clinical decision of a rheumatologist. M mode and Doppler echocardiographic examinations were performed. Pericardial effusion was graded as: small, moderate and large. Attacks were grouped as presence of PE; Group I (without PE) and Group II (with PE). Results Forty three attacks of 37 patients were investigated. There were 11 male, 26 female; mean age was 33±12 years and the disease (FMF) duration was 13±9 years. The frequency of PE was determined as 30% (13/47). All PE was at small grade and have clear view on echocardiography. Echocardiography has not revealed segmental wall motion abnormalities in any patient. After dividing patients as presence of PE, 30 patients were in group I, 13 patients were in group II. When we compared, basal characteristics, echocardiographical and laboratory findings the presence of PE was not related to gender, usage of colchicines or response to colchicines. Mean age of group II was significantly higher; 31±12 vs. 39±7.5; p=0.012. The disease duration and age of diagnosis were higher in group II, the differences was borderline to statistical significance; p=0.058, p=0.055, respectively. All patients had normal ECG. Echocardiography has not revealed segmental wall motion abnormalities in any patient and all had normal left ventricular ejection fraction. Conclusions The main finding of the study is that the frequency of PE is 30% in our FMF cohort during attack period. Older patients and patients with longer disease duration are seem to more prone to develop pericardial involvement. Our finding supported the previous studies reported by Terekeci (1) and Dabestani (2) et al. that the incidence of PE were 23,3% and 27%, respectively. PE showed that minimal PE is more frequent than previous studies and can be easily diagnosed with echocardiography in patients with FMF during attack period. Disclosure of Interest None Declared
    Annals of the Rheumatic Diseases 01/2014; 71(Suppl 3):708-708. DOI:10.1136/annrheumdis-2012-eular.1229 · 10.38 Impact Factor
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    ABSTRACT: Giant cell arteritis is a granulomatous vasculitis characterized by medium or large sized vessel involvement. Although extracranial branches of the carotid artery are typically involved, involvement of aorta and its major branches can also be seen. Cardiac involvement has been encountered less frequently and pericardial effusion is rarely encountered. In this paper, a case has been presented in which pericardial effusion was determined during the examination and diagnosis was giant cell arteritis.
    01/2014; 2014:424295. DOI:10.1155/2014/424295
  • Safak Sahin · Soner Senel · Saadettin Kilickap
    01/2014; 3(1):67-69. DOI:10.5505/abantmedj.2014.84755
  • 01/2014; 3(1):99-104. DOI:10.5505/abantmedj.2014.44265
  • 01/2014; 4(3):1. DOI:10.5455/ctd.2014-158
  • 01/2014; 3(3):1. DOI:10.5455/ctd.2013-132
  • 01/2014; 4(1):1. DOI:10.5455/ctd.2013-130
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    ABSTRACT: Abstract Introduction: A relationship between atrial conduction time and hypertension was shown in previous studies. Increased atrial electromechanical intervals used to predict atrial fibrillation by measured tissue Doppler imaging (TDI). So we aimed to search if there was any association between the non-dipping status and atrial electromechanical intervals in pre-hypertensive patients. Methods: Forty-one non-dipper and 33 dipper pre-hypertensive subjects enrolled in the study. Systolic and diastolic blood pressures were measured with a mercury sphygmomanometer. Twenty-four hours blood pressure was measured with cuff-oscillometric method. All patients were evaluated by transthoracic echocardiography. Using tissue Doppler imaging (TDI), atrial electromechanical coupling (PA) was measured from the lateral mitral annulus (PA lateral), septal mitral annulus (PA septum) and right ventricular tricuspid annulus (PA tricuspid). Results: Systolic and diastolic blood pressures were significantly higher in subjects with non-dipper phenomenon than dipper ones at night. Twenty-four hours average systolic and diastolic blood pressures were higher in non-dipper pre-hypertensive subjects, but this elevation was not significant. Left and right intraatrial (PA lateral-PA septum and PA septum-PA tricuspid) and interatrial (PA lateral-PA tricuspid) electromechanical coupling intervals were measured significantly higher in non-dipper pre-hypertensive patients (31.3 ± 3.9 versus 24.1 ± 2.3, p = 0.001; 19.5 ± 4.3 versus 13.8 ± 2.1, p = 0.001; and 11.4 ± 2.8 versus 8.8 ± 1.5, p = 0.001). Also, interatrial electromechanical delay was negatively correlated with dipping levels. Conclusion: This study showed that prolonged atrial electromechanical intervals were related non-dipper pattern in pre-hypertensive patients. Prolonged electromechanical intervals may be an early sign of subclinical atrial dysfunction and arrhythmias' in non-dipper pre-hypertensive patients.
    Clinical and Experimental Hypertension 10/2013; 36(7). DOI:10.3109/10641963.2013.846362 · 1.46 Impact Factor
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    ABSTRACT: Introduction: Studies conducted so far on the effect of hyperthyroidism on oxidative stress (OS) have employed blood and urine samples. Exhaled Breath Condensate (EBC) is a non-invasive technique used to take sample from lungs to determine many biological indications. The aim of the present study was determine the possibility of using 8-isoprostane levels in EBC as an indicator of OS in hyperthyroid patients. Methods: The present study was performed on 42 patients with hyperthyroidism and 42 healthy control subjects. Hyperthyroid patients included patients with newly diagnosed Graves' disease, toxic multinodular goiter and toxic adenoma. Exhaled breath condensates were collected from patients in each group using a condensing device. 8-isoprostane levels as an indicator of OS in EBC were detected via immunoassay method. Results: Hyperthyroid patients and control groups had 8-isoprostane levels of 6.08±6.31 and 1.56±0.88 pg/ml, respectively. The difference between patient and control groups was statistically significant (p<0.001). Of the hyperthyroid patients, eleven had Graves', 21 multinodular goiter, and 10 toxic adenoma diagnosis. There were no significant differences among patients of different diagnoses for 8-isoprostane levels (p=0.541). No significant correlations were found between 8-isoprostane and free thyroxine (fT4) or thyroid stimulating hormone (TSH) levels. Conclusion: In the present study, 8-isoprostane levels in EBC of hyperthyroid patients were found to be significantly higher than that in healthy control group. This study is important in that it is the first to evaluate the effects on respiratory system of elevated OS of hyperthyroidism in EBC.
    10/2013; DOI:10.2174/18715303113136660043
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    ABSTRACT: Abstract The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the production of antiphospholipid antibodies (aPL) that promote vascular thrombosis and pregnancy loss. APS can occur in the absence of underlying or associated disease (primary APS) or in combination with other diseases (secondary APS). Mean platelet volume (MPV) is largely regarded as a useful surrogate marker of platelet activation. We aimed to investigate if there is a relationship between MPV and thrombotic events in APS. The study consisted of 22 patients and 22 healthy controls. Group 1 is defined as all the patients in the first day of thrombotic event. Group 2 is defined as the same patient population three months after the thrombotic event. The erythrocyte sedimentation rate, C-reactive protein, white blood cell count, platelet count, and MPV levels were retrospectively recorded from patient files. Statistical analyses showed that MPV was significantly higher in group 1 than group 2 (p < 0.0001) and healthy controls (p < 0.05). However, there was no difference between group 2 and healthy controls (p = 0.888). WBC, hemoglobin and other platelet indices such as platelet distribution width and platecrit did not differ in groups. In conclusion, MPV was increased at initial thrombotic event of APS, and then it was normalized three months later by therapeutic interventions. To our knowledge, this is the first study demonstrating a correlation between MPV and thrombotic events in APS.
    Platelets 08/2013; 25(5). DOI:10.3109/09537104.2013.824563 · 2.63 Impact Factor
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    ABSTRACT: Central corneal thickness and dry eye tests were evaluated in a study population consisting of 68 ankylosing spondylitis patients diagnosed according to the modified New York criteria, and 61 age-matched controls without ankylosing spondylitis. A full ophthalmological evaluation was performed on each subject. All subjects were screened for age, gender, HLA-B27, tear break-up time test, Schirmer test, and duration of disease. Central corneal thickness was measured under topical anesthesia with an ultrasonic pachymeter. The mean central corneal thickness was 537.3 ± 30.6 μm, range 462-600 μm, in ankylosing spondylitis patients, whereas it was 551.7 ± 25.2 μm, range 510-620 μm, in controls (p = 0.005). The Schirmer test result was 7.3 ± 5.9 mm for the ankylosing spondylitis patients and 11.7 ± 5.8 mm for the control group (p = 0.002). Tear break-up time was 7.3 ± 3.2 s for the ankylosing spondylitis patients and 14.0 ± 4.5 s for the control group (p < 0.001). The possibility of a thinner cornea should be taken into consideration in ankylosing spondylitis. In addition, attention must be given to lower dry eye tests in surgical interventions such as photorefractive keratectomy and laser in situ keratomileusis in ankylosing spondylitis patients.
    International Ophthalmology 07/2013; 34(2). DOI:10.1007/s10792-013-9827-2 · 0.55 Impact Factor
  • S Sahin · I Yalcin · S Senel · H Ataseven · Au Uslu · O Yildirim · M Semiz
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    ABSTRACT: Familial Mediterranean fever is an auto-inflammatory disorder. Long term complications of the disease include decreased quality of life. The measurement of quality of life in the patients with chronic disease has become an important research topic during the last years. We aimed to evaluate life quality of the FMF patients by SF-36, and examine its relationship with the disease parameters. One hundred voluntary patients (69 female, 31 male) admitted to the rheumatology clinic were included in the study. The control group consisted of 100 healthy individuals. All subjects in the study were asked to complete SF-36 questionnaire. Age of onset of FMF, age at diagnosis, age at the beginning of colchicine therapy, number of attacks per month, family history of FMF and dialysis were inquired of patients with FMF. Disease severity was determined using the FMF severity score. The mean age of the patient group was 31±12 and that of the control group was 29±9. Sixty-nine patients (69%) were female, and 31 patients were male (31%) in both groups. The mean scores of the physical function, physical role function, emotional role function, mental health, and general health parameters of the patients were statistically significantly lower than those of healthy volunteers (p < 0.05). The difference in social function and vitality between two groups was found to be insignificant (p > 0.05). We have shown that FMF had a negative impact on SF-36. FMF reduces quality of life both in physical and mental dimensions.
    European review for medical and pharmacological sciences 04/2013; 17(7):958-63. DOI:10.1136/annrheumdis-2013-eular.1010 · 0.99 Impact Factor
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    ABSTRACT: Aim Oral anticoagulants are the most common used substance for treatment and prophylaxis of warfarin venous and arterial thromboembolic disorders in the world. Therapeutic index of warfarin is narrow. CYP2C9 is a hepatic microsomal enzyme and has a primary role in metabolism of warfarin and genetic variations of CYP2C9 may cause a serious effect on the response to warfarin in patients. The aim of this study was to determine the eficiency of CYP2C9 gene polymorphisms on drug metabolism in patients who had upper gastrointestinal system bleeding while using warfarin. Methods There was a total of 67 patients in this study, 37 of whom had upper gastrointestinal system bleeding when INR was above 3 while using warfarin (group 1), 30 of whom had no bleeding and INR was stable under 3 (group 2). Results There was no difference in terms of warfarin dose used among the groups (p>0.05). Mutant genotype, INR and aspirin usage were found signiicantly different in the group with bleeding (p less 0.05). When analyzed in terms of drug interaction, there was no difference between the two groups (p>0.05). Logistic regression analysis was made in order to determine the risk factors that may cause bleeding. Aspirin usage (p= 0.016) and genetic polymorphism (p= 0.024) were related to the increased risk of bleeding. Conclusion CYP2C9*2 and CYP2C9*3 polymorphisms were related to the increase of excessive anticoagulation and bleeding risk in the patients who used warfarin.
    Medicinski glasnik 02/2013; 10(1):50-4. · 0.20 Impact Factor
  • 01/2013; 2(1):32-35. DOI:10.5505/abantmedj.2013.27247
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    ABSTRACT: The present study examined the heart rate turbulence (HRT) and heart rate variability (HRV) parameters in healthy young smokers (<40 years) to assess the effects of smoking on cardiac autonomic function. The study included 75 smokers with a history of habitual smoking for at least 1 year (41 males and 34 females; mean age, 29.3 ± 7.3 years) and 30 nonsmokers (hospital staff; 16 males and 14 females; mean age, 29.0 ± 6.1 years). Addiction to smoking was evaluated using the modified Fagerström test for nicotine-dependence index (NDI). HRT, HRV, basic clinical and echocardiographic, and Holter test parameters were compared between groups. No significant differences between the two groups were found in the basic clinical and echocardiographic variables. Turbulence onset (TO) was significantly higher in the smoking group than in the controls, and turbulence slope was significantly lower in the smokers, than in the controls (p < 0.05). Standard deviation of all normal-to-normal (NN) interval index (SDNNI) was the only HRV parameter that was significantly different between the smoking and control groups (p < 0.05). The NDI was positively correlated with the TO (p < 0.05). Smoking impairs the baroregulatory function in healthy young smokers, particularly the HRT parameters and SDNNI. Our findings highlight the importance of complete smoking cessation.
    Toxicology and Industrial Health 12/2012; 31(1). DOI:10.1177/0748233712468024 · 1.71 Impact Factor