Jesus Maria Dominguez

Hospital Clínic de Barcelona, Barcino, Catalonia, Spain

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Publications (3)5.46 Total impact

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    Ultrasound in Obstetrics and Gynecology 09/2012; 40(S1). · 3.56 Impact Factor
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    ABSTRACT: Assessment of cardiac function in the fetal heart is challenging because of its small size and high heart rate, restricted physical access to the fetus, and impossibility of fetal ECG recording. We aimed to standardize the acquisition and postprocessing of fetal echocardiography for deformation analysis and to assess its feasibility, reproducibility, and correlation for longitudinal strain and strain rate measurements by tissue Doppler imaging (TDI) and 2D speckle tracking (2D-strain) during pregnancy. Echocardiography was performed in 56 fetuses. 2D and color TDI in apical or basal four-chamber views were recorded for subsequent analysis. Caution was taken to achieve a frame rate >70 Hz for speckle tracking and >150 Hz for TDI analysis. For each acquisition, 7.5 s of noncompressed data were stored in cine loop format and analyzed offline. Since fetal ECG information is by definition not available, aortic valve closure was marked from aortic flow and the onset of each cardiac cycle was manually indicated in the 2D images. Sample volume length was standardized at the minimum size. Two observers measured the left and right ventricular peak systolic longitudinal strain and strain-rate. Strain and strain rate measurements were feasible in 93% of the TDI and 2D-strain acquisitions. The mean time spent on analyzing TDI images was 18 min, with an intraclass agreement coefficient of 0.86 (95% CI 0.77-0.92), 0.83 (95% CI 0.72-0.90), 0.96 (95% CI 0.93-0.98), and 0.86 (95% CI 0.76-0.92) for basal left and right free wall peak systolic strain and strain rate, respectively. Agreement between observers using tissue Doppler also showed high reliability. The mean time spent for 2D-strain analysis was 15 min, with an intraclass agreement coefficient of 0.97 (95% CI 0.95-0.98), 0.94 (95% CI 0.89-0.96), 0.96 (95% CI 0.93-0.98), and 0.84 (95% CI 0.73-0.90) for basal left and right free wall peak systolic strain and strain rate, respectively. Agreement between observers also showed a high reliability that was similar for TDI and 2D-strain. There was a weak correlation between TDI and 2D-strain measurements. A standard protocol with fixed acquisition and processing settings, including manual indication of the timing events of the cardiac cycle to correct for the lack of ECG, was feasible and reproducible for the evaluation of longitudinal ventricular strain and strain rate of the fetal heart by TDI as well as 2D-strain analysis. However, both techniques are not interchangeable as the correlation between them is relatively poor.
    Fetal Diagnosis and Therapy 06/2012; 32(1-2):96-108. · 1.90 Impact Factor
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    ABSTRACT: Purpose: As it has been reported that ultrasound (US) backscattering changes according to tissue microstructure, we evaluated whether exists an association between invariant image features of B-mode ultrasound (US) and histological changes in arteries of rabbits with induced Atherosclerotic Vascular Disease (AVD) at early stages. Methods: AVD was induced to 20 of a total of 40 New Zealand Rabbits that were fed with a 1% cholesterol supplemented diet for 70 days. Vascular US images were acquired during anesthetic stage, obtaining samples from ascendant aorta. Histological study was performed to quantify collagen, elastin and lipids. B-mode US images were manually delineated by an expert and processed by Automated Quantitative Ultrasound Analysis (AQUA) to extract invariant image features. We evaluated association between US invariant image features and histological quantification, firstly, by partial least squares (PLS) regression and secondly, by computing R squared only within the AVD rabbits to evaluate whether subtle histological changes within AVD rabbits corresponded to consistent changes of invariant image features. Results: Average and standard deviation of intima-media thickness was 0.4 and 0.2 mm for control and 0.6 and 0.2 mm for AVD. Lipids and collagen increased significantly in AVD rabbits. PLS regression resulted in R squared of 0.88 and R squared only within the AVD rabbits resulted in 0.85 and p < 0.0001. Conclusions: B-mode US invariant image features can be associated with histological changes and these changes are consistent with subtle histological changes that correspond to different degrees of AVD. This suggests that (1) the well differentiated acoustic properties of lipids compared to elastin, collagen and water produce a contrast in the US images of AVD rabbits that can be robustly measured by invariant image features and that (2) US invariant image features can develop predictive models of intima-media microstructure. Further research will be focused on developing systems to estimate specific microstructural aspects of wall vessel and the associated cardiovascular risk.
    2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, London, England; 04/2012