Jong Bin Lee MD

Publications (2)3.5 Total impact

• Article: Korean red ginseng prevents gentamicin‐induced hearing loss in rats

  Yun-Hoon Choung DDS, MD, PhD, Seung Won Kim MD, Chunjie Tian MD, Ji Young Min, Hae Kyoung Lee, Shi-Nae Park MD, Jong Bin Lee MD, PhD Keehyun Park MD
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  ABSTRACT: Objectives:To evaluate the preventive effects of Korean red ginseng (KRG) on gentamicin (GM)-induced ototoxicity and to identify the effective components of KRG.Study Design:In vivo and in vitro studies.Methods:Thirty-five Sprague-Dawley rats were divided into four groups. The GM group (n = 15) received intraperitoneal injections (IPI) of GM (160 mg/kg) for 5 days. The KRG + GM group (n = 12) was treated with intragastric feeding of KRG (500 mg/kg) for 12 days with 5 days of IPIs of GM. KRG (n = 4) and control (n = 4) groups were treated with KRG and saline, respectively. Auditory brainstem response (16 or 32 kHz) and Rotarod treadmill tests were done before and after treatments. Cochleas were evaluated by a scanning electron microscope (SEM) and phalloidin staining. Ginsenosides Rb1, Rb2, Rg1, and Re were evaluated as the water-soluble terazolium salt assay, annexin V/propidium iodide assay, and Western blots in HEI-OC1 cells.Results:Posttreatment hearing thresholds in GM, KRG + GM, KRG, and control groups were: 27.7 ± 7.2 dB, 23.1 ± 4.1 dB, 16.9 ± 2.6 dB, and 21.3 ± 3.5 dB, respectively, for 16 kHz, 30.5 ± 6.6 dB, 25.2 ± 4.3 dB, 22.5 ± 2.7 dB, and 22.5 ± 3.8 dB, respectively for 32 kHz. The KRG + GM group had significantly better hearing than the GM group (P < .05). On SEM and phalloidin staining, the GM group showed severe loss of stereocilia in the basal outer hair cells and a few losses in the middle turns, whereas the KRG + GM group showed relatively intact hair cells. Balance impairment in treadmill tests was not definite in any group. Rb1 and Rb2 showed more effective protection than other components.Conclusions:KRG protects against GM-induced hearing loss and hair cell death in rats. Laryngoscope, 2011
  The Laryngoscope 05/2011; 121(6):1294 - 1302. · 1.75 Impact Factor
• Article: Efficacy of the “bow and lean test” for the management of horizontal canal benign paroxysmal positional vertigo

  Jong Bin Lee MD, Dong Hee Han MD, Seong Jun Choi MD, PhD Keehyun Park MD, Hun Yi Park MD, In Kyung Sohn MD, Yun-Hoon Choung DDS, MD, PhD
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  ABSTRACT: Objectives/Hypothesis:Horizontal semicircular canal (HSC) benign paroxysmal positional vertigo (BPPV) has been reported to have a poorer prognosis than posterior semicircular canal BPPV. Incorrect determination of the affected ear appears to be one of the causes of poorer outcome. The aim of this study was to assess the efficacy of the “bow and lean test” (BLT) for proper determination of the affected ear followed by preferable treatment outcomes of HSC-BPPV.Study Design:A prospective study.Methods:The 211 patients (225 cases) with HSC-BPPV were sequentially classified into two groups by hospital visiting time and diagnostic methods. The head roll test (HRT) group (61 cases) was treated with canalith repositioning procedure (CRP) on the basis of the results of HRT alone between 2001 and 2004. The BLT group (164 cases) was treated based on the results of both BLT and HRT from 2005 to 2008.Results:The remission rates after two sessions of CRPs in the BLT group and the HRT group were 83.1% and 67.4% (P = .041), respectively, for the canalolithiasis type and 74.7% and 61.1% (P = .250), respectively, for the cupulolithiasis type. In the BLT group, 76.8% had bowing and/or leaning nystagmus; 35.7% of them (45 of 126 cases) benefited from BLT with regard to determining the affected ears because HRT was unable to provide the definitive affected ears (17 cases) or showed different localization between two methods (28 cases).Conclusions:BLT is a useful method to improve the remission rates of HSC-BPPV, giving more corrective information regarding affected ears than the HRT alone. Laryngoscope, 2010
  The Laryngoscope 10/2010; 120(11):2339 - 2346. · 1.75 Impact Factor