Roy Hamilton MD,
Sunil Patel MS,
Edward B. Lee MD,
Eric M. Jackson MD,
Joanna Lopinto BSN, RN, CCRP,
Steven E. Arnold MD,
Christopher M. Clark MD,
Anuj Basil MD,
Leslie M. Shaw PhD,
Sharon X. Xie PhD, [......],
Edward B. Lee,
Eric M. Jackson,
Joanna Lopinto,
Steven E. Arnold,
Christopher M. Clark,
Anuj Basil,
Leslie M. Shaw,
Sharon X. Xie,
M. Sean Grady,
John Q. Trojanowski
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ABSTRACT: To determine the impact of cortical Alzheimer disease pathology on shunt responsiveness in individuals treated for idiopathic normal pressure hydrocephalus (iNPH), 37 patients clinically diagnosed with iNPH participated in a prospective study in which performance on neurologic, psychometric, and gait measures before and 4 months after shunting was correlated with amyloid β plaques, neuritic plaques, and neurofibrillary tangles observed in cortical biopsies obtained during shunt insertion. No complications resulted from biopsy acquisition. Moderate to severe pathology was associated with worse baseline cognitive performance and diminished postoperative improvement on NPH symptom severity scales, gait measures, and cognitive instruments compared to patients lacking pathology. ANN NEUROL 2010
Annals of Neurology 09/2010; 68(4):535 - 540. · 11.09 Impact Factor
