Publications (1)0 Total impact
ABSTRACT: It is proposed that the central nervous system undergoes plastic changes in response to peripheral stimuli and new experiences.
Consequently, alterations along central signaling processing system affect subsequent responses of animals and humans to the
environment. Such long-term plastic changes not only play roles in important physiological functions such as learning and
memory, but also are indispensable in unwanted pathological conditions such as chronic pain, drug addiction, and mental disorders.
Investigation of such long-term plasticity using different animal models helps us to understand the molecular mechanism of
brain functions. Here, I review recent work in the spinal cord dorsal horn, amygdale, and anterior cingulate cortex (ACC),
and discuss the injury and learning-related changes in different regions of the brain and their implications in brain functions
and mental disorders.
12/2005: pages 377-388;
University of Toronto