GIUSEPPE STABILE M.D,
FRANCESCO SOLIMENE M.D,
EMANUELE BERTAGLIA M.D,
VINCENZO LA ROCCA M.D, MICHELE ACCOGLI M.D,
ALBERTO SCACCIA M.D,
NATALE MARRAZZO M.D,
FRANCO ZOPPO M.D,
PIETRO TURCO M.D,
ASSUNTA IULIANO M.D, [......],
VINCENZO LA ROCCA,
MICHELE ACCOGLI,
ALBERTO SCACCIA,
NATALE MARRAZZO,
FRANCO ZOPPO,
PIETRO TURCO,
ASSUNTA IULIANO,
GERGANA SHOPOVA,
CARMINE CIARDIELLO,
ANTONIO DE SIMONE
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ABSTRACT: Objective: To compare the rates of all-cause mortality in recipients of cardiac resynchronization therapy devices without (CRT-PM) versus with defibrillator (CRT-D).Methods: Between February 1999 and July 2004, 233 patients (mean age = 69 ± 8 years, 180 men) underwent implantation of CRT-PM or CRT-D devices. New York Heart Association (NYHA) heart failure functional class II was present in 11%, class III in 69%, and class IV in 20% of patients; mean left ventricle ejection fraction (LVEF) was 26.5 ± 6.5 %, 48% presented with idiopathic dilated cardiomyopathy and 49% with ischemic heart disease. Cox multiple variable regression analysis was performed in search of predictors of death.Results: The clinical characteristics of the 117 CRT-PM and 116 CRT-D recipients were similar, except for LVEF (28.2 ± 6.2% vs 25.0 ± 6.5%, respectively; P < 0.001), and ischemic versus nonischemic etiology of heart failure (41% vs 56%, respectively P = 0.02). Over a mean follow-up of 58 ± 15 months, no significance difference in overall mortality rate was observed between the two study groups. Male sex, NYHA functional class IV, and atrial fibrillation at implant were significant predictors of death.Conclusions: There was no difference in long-term survival rate among patients with CRT-D versus CRT-PM, although CRT-D more effectively lowered the sudden death rate. Male sex, NYHA functional class IV, and atrial fibrillation predicted the worst prognosis.
Pacing and Clinical Electrophysiology 02/2009; 32(s1):S141 - S145. · 1.35 Impact Factor
