[show abstract][hide abstract] ABSTRACT: Morinda citrifolia L. (noni) fruit has been used in tropical regions as both food and folk medicine. The recent use of noni as a dietary supplement has increased greatly. To describe the safety of this fruit, a literature review and data from new studies are presented. Several preclinical safety tests and a human clinical safety study have revealed no adverse health effects, even at high doses. The available data substantiate its continued use as a safe food.