N Moiseeva

Tourette Syndrome Foundation of Canada, Mississauga, Ontario, Canada

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Publications (4)4.23 Total impact

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    ABSTRACT: The brain mechanisms that subserve music recognition remain unclear despite increasing interest in this process. Here we report the results of a magnetoencephalography experiment to determine the temporal dynamics and spatial distribution of brain regions activated during listening to a familiar and unfamiliar instrumental melody in control adults and adults with Down syndrome (DS). In the control group, listening to the familiar melody relative to the unfamiliar melody, revealed early and significant activations in the left primary auditory cortex, followed by activity in the limbic and sensory-motor regions and finally, activation in the motor related areas. In the DS group, listening to the familiar melody relative to the unfamiliar melody revealed increased significant activations in only three regions. Activity began in the left primary auditory cortex and the superior temporal gyrus and was followed by enhanced activity in the right precentral gyrus. These data suggest that familiar music is associated with auditory-motor coupling but does not activate brain areas involved in emotional processing in DS. These findings reveal new insights on the neural basis of music perception in DS as well as the temporal course of neural activity in control adults.
    Brain and Cognition 12/2012; 81(2):256-262. · 2.82 Impact Factor
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    N Virji-Babul, A Rose, N Moiseeva, N Makan
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    ABSTRACT: Mirror neurons are recognized as a crucial aspect of motor and social learning yet we know little about their origins and development. Two competing hypotheses are highlighted in the literature. One suggests that mirror neurons may be innate and are an adaptation for action understanding. The alternative, proposes that mirror neurons develop through sensorimotor experience. To date, there has been little direct evidence from infant studies to support either argument. In the present study, we explored the temporal dynamics and spatial distribution of electroencephalography (EEG) brain responses in young infants during the observation of three distinct types of actions: (a) actions that are within the motor repertoire of infants, (b) actions that are not within the motor repertoire of infants, and (c) object motion. We show that young infants had significant motor resonance to all types of actions in the sensorimotor regions. Only observation of human goal-directed actions led to significant responses in the parietal regions. Importantly, there was no significant mu desychronization observed in the temporal regions under any observation condition. In addition, the onset of mu desychronization occurred earliest in response to object motion, followed by reaching, and finally walking. Our results suggest that the infants may have a basic, experience-independent sensorimotor mechanism optimized to detect all coherent motion that is modulated by experience.
    Brain and behavior. 05/2012; 2(3):237-42.
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    ABSTRACT: Individuals with Down syndrome have well known cognitive and sensorimotor impairments, however, the underlying neural processes are poorly understood. The objective of this study was to investigate the underlying spatial localization and functional connectivity during voluntary movements of the right index finger. Adults with Down syndrome and healthy control adults participated in this study. Cortical responses were recorded with a 151-channel magnetoencephalographic system. In the Down syndrome group, we observed two distinct patterns of brain activation, an ipsilateral pattern and a contralateral pattern in the low-frequency band. The two distinct patterns of neural activation and the altered underlying network dynamics have not been reported previously, and may reflect differences in sensorimotor organization.
    Neuroreport 04/2011; 22(7):358-64. · 1.40 Impact Factor
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    ABSTRACT: We previously reported that in a small group of right handed adults with Down syndrome (DS), voluntary finger movements were characterized by ipsilateral dominance. The aim of this study was to examine the dynamics of network connectivity during the same motion. Thirteen typical adults and twelve adults with DS participated in this study. Cortical responses were recorded with a 151 channel MEG system (VSM MedTech). Subjects pressed a button on the keypad using their right index finger. The SAM beamformer was used to obtain spatial distributions of the evoked activity in 0.2 – 50Hz, 0.2-12Hz and 12-50Hz frequency bands. Individual distributions were spatially normalized to a standard template brain using SPM and averaged. Locations with the highest evoked signal to noise ratio in the normalized averaged data were found, and transformed back to each subject’s original brain coordinates. For the control group the most significant activation in the low frequency band was in the contralateral motor region. In the high frequency band, significant activations were found in bilateral motor regions. In the DS group, we observed two distinct patterns of activation: an ipsilateral dominance and a contralateral dominance in the low frequency band. DS individuals were subsequently divided into two subgroups based on laterality calculated in the broadband (0.2-50Hz). The ipsilateral group (n=6) showed largest activations in the right temporal region at low frequencies. At high frequencies the distribution was bilateral, involving both motor and temporal regions. The strongest peaks in the contralateral group (n=6) were found in the left motor area for both low and high frequency bands. PLV analysis showed significant differences in connected locations between the controls and the DS ipsilateral and contralateral groups. Further work is needed to better understand the emergence of these two distinct patterns of neural activity. KeywordsDown syndrome-motor control-phase locking-functional connectivity
    12/2009: pages 393-396;

Publication Stats

9 Citations
4.23 Total Impact Points

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  • 2009
    • Tourette Syndrome Foundation of Canada
      Mississauga, Ontario, Canada