Mohammad‐Reza Zarrindast

Publications (2)0 Total impact

• Article: Effects of Lead Exposure on Licking and Yawning Behaviour in Rats

  Mahmoud Ghazi‐Khansari, Niloufar Rezvani, Shadi Bani‐Assadi, Mohammad‐Reza Zarrindast
  [show abstract] [hide abstract]
  ABSTRACT: In the present study, effects of lead exposure on licking and yawning behaviour have been studied. The dopaminergic receptor agonist, apomorphine (0.15, 0.25 and 0.5 mg/kg), induced dose-dependent licking in rats. The maximum response was obtained with 0.5 mg/kg of the apomorphine. Lead acetate (0.05%) exposure significantly increased apomorphine-induced licking. Yawning induced by the D2 dopaminergic agonist, bromocriptine (2, 3, 4, 8 mg/kg), and the cholinergic drug, physostigmine (0.1 or 0.3 mg/kg), was significantly decreased by lead acetate (0.05%) exposure. It may be concluded that the behaviour induced by dopaminergic or cholinergic agents can be affected by lead subchronic exposure.
  Pharmacology &amp Toxicology 08/1998; 83(3):120 - 124.
• Article: Effects of Lead Exposure on Bromocriptine‐Induced Penile Erection in Rats

  Mahmoud Ghazi-Khansari, Ismaeel Heidari, Mohammad‐Reza Zarrindast
  [show abstract] [hide abstract]
  ABSTRACT: In the present work we have studied the effects of lead exposure on penile erection induced by bromocriptine. Intraperitoneal injection of bromocriptine (2, 3, 4 and 8 mg/kg) induced dose-related penile erection in rats. Maximum response was observed with 4 mg/kg of the drug. Lead exposure (as Pb-acetate in drinking water) for periods of 7, 14, 21 and 28 days decreased the bromocriptine-induced penile erection response. Higher concentrations of lead (0.05%) were shown to cause a more prominent decrease of penile erection. The same procedure for lead administration did not significantly alter penile erection induced by physostigmine (0.1 and 0.3 mg/kg, intraperitoneally). In a series of experiments, blood lead concentrations were measured 7 and 21 days after lead exposure. Significant increases of lead concentrations were found after lead exposure. It is concluded that lead can influence bromocriptine-induced penile erection.
  Pharmacology &amp Toxicology 07/1997; 81(2):81 - 84.