ABSTRACT: There is a renewed interest in fibrinogen today and its importance for hemostasis [1,2]. The use of fibrinogen concentrate has been associated with improved outcome compared to transfusion of plasma  and perioperative supplementation with fibrinogen has reduced bleeding and transfusion requirements [3-5]. All available fibrinogen concentrates are today derived from human plasma but there are development projects aiming to produce recombinant human fibrinogen. The present study compares for the first time the functional properties of recombinant fibrinogen derived from a human cell line with fibrinogen derived from human plasma. © 2012 International Society on Thrombosis and Haemostasis.
Journal of Thrombosis and Haemostasis 06/2012; 10(8):1696-8. · 5.73 Impact Factor