Dieter Körholz MD

Publications (1)4.77 Total impact

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  Available from: Dirk Hasenclever

  Article: Resection alone in 58 children with limited stage, lymphocyte‐predominant Hodgkin lymphoma–experience from the European network group on pediatric Hodgkin lymphoma

  Christine Mauz-Körholz MD, Stephanie Gorde-Grosjean MD, Dirk Hasenclever PhD, Ananth Shankar MD, Wolfgang Dörffel MD, W. Hamish Wallace MD, Günther Schellong MD, Alain Robert MD, Dieter Körholz MD, Odile Oberlin MD, [......], Dirk Hasenclever, Ananth Shankar, Wolfgang Dörffel, W. Hamish Wallace, Günther Schellong, Alain Robert, Dieter Körholz, Odile Oberlin, Georgina W. Hall, Judith Landman‐Parker
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  ABSTRACT: BACKGROUND.Lymphocyte-predominant Hodgkin lymphoma (LPHL) is a rare, CD20-positive, good prognostic lymphoma in children. Patients with early-stage LPHL who underwent successful surgical lymph node resection alone have been reported. To clarify the optimum treatment strategy in children, European study groups were asked to report their experience of surgery alone used in the treatment of pediatric LPHL.METHODS.Data from 58 patients were collected by the French Society for Pediatric Cancers, the German-Austrian Pediatric Study Group/German Society of Pediatric Oncology and Hematology (Germany), and the Children's Cancer and Leukaemia Group (United Kingdom). In total, there were 50 boys and 8 girls, and the median age was 11 years (age range, 4-17 years). Fifty-four patients had stage IA disease, 2 patients had stage IIA disease, and 2 patients had stage IIIA disease.RESULTS.With a median follow-up of 43 months (range, 2-202 months), the overall survival rate was 100%, and the progression-free survival (PFS) rate was 57%. Fifty-one of 58 patients achieved complete remission (CR) after surgery. In the CR group, the overall PFS rate was 67% (95% confidence interval, 51-82%). All seven patients who had residual disease after initial surgery developed recurrences (P = .003). Among 18 patients with stage IA LPHL who developed recurrent disease, 11 patients had local recurrences, and 7 patients recurred in stage IIA. One patient with stage IIIA disease presented with high-grade B-cell non-Hodgkin lymphoma at 10 years of follow-up.CONCLUSIONS.When complete resection was achieved, a substantial proportion of patients with surgically treated, early-stage LPHL experienced long-term remission and actually may have been cured. Cancer 2007. © 2007 American Cancer Society.
  Cancer 06/2007; 110(1):179 - 185. · 4.77 Impact Factor