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ABSTRACT: Tight junction is the apical most structure in epithelium as well as in the endothelium. Its main function is to control the
paracellular diffusion of ions and certain molecules. Although the structure has been known for decades, the molecular composition
of the tight junction has only been recognised in the past decade. Molecules making up tight junctions include the transmembrane
proteins occludin, claudin and paracellin, and cytoplasmic proteins, MAGUK family members. The structure has now been demonstrated
as also having a role in the control of cancer cell penetration of the endothelium and in the development of cancer.
04/2006: pages 195-213;