Devendra P. Mishra

Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Publications (2)4.58 Total impact

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    ABSTRACT: Hypaphorine, an α-N,N,N-trimethyltryptophan betaine, is isolated as major constituent from Impatiens niamniamensis seeds (Balsaminaceae) for the first time. The structure of the compound was established by spectroscopic data. This is the first report of its in vivo evaluation for antihyperglycemic activity. The ethanolic extract of the seeds showed mild antihyperglycemic activity at the dose of 200mg/kg body weight, whereas, hypaphorine showed significant activity in streptozotocin-induced diabetic rats at the dose of 50mg/kg body weight when compared to standard drug metformin (100mg/kg). Keywords Impatiens niamniamensis –Hypaphorine–Tryptophan betaine–Antihyperglycemic activity–STZ
    Medicinal Chemistry Research 01/2011; 20(9):1505-1508. · 1.61 Impact Factor
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    ABSTRACT: The objective of this study was to determine the in vitro osteogenic activities of selected medicinal plants used traditionally in India. The compounds isolated from three plants viz. Allophylus serratus, Cissus quadrangularis and Vitex negundo were evaluated for their in vitro osteogenic activities. Primary cultures of osteoblasts were used to determine the effects of these components on osteoblast functions. Five of the fourteen compounds isolated led to increase in osteoblast differentiation and mineralization. These findings lend support to the use of Allophylus serratus, Cissus quadrangularis and Vitex negundo in traditional medicine.
    Phytomedicine: international journal of phytotherapy and phytopharmacology 11/2010; 17(13):993-9. · 2.97 Impact Factor

Publication Stats

2 Citations
185 Downloads
354 Views
4.58 Total Impact Points

Institutions

  • 2011
    • Central Drug Research Institute
      • Medicinal and Process Chemistry Division (CDRI)
      Lucknow, Uttar Pradesh, India