Publications (2)0 Total impact
Article: Organization of Interneuronal Connections in the Nucleus Accumbens in “Impulsive” and “Self-Controlled” Behavior in Cats[show abstract] [hide abstract]
ABSTRACT: In behavioral experiments, cats placed in a situation of choosing between a high-value time-delayed and a low-value rapid food reinforcement elected to wait for the preferred reward (they demonstrated “selfcontrol”) or to obtain the worse reward quickly (they demonstrated impulsive behavior). On the basis of the selected behavioral strategy, the cats were divided into three groups – “impulsive,” “ambivalent,” and “self-controlled.” Cross-correlation analysis was used to assess the linked activity of cells in the nucleus accumbens, which reflects the nature of interactions between close-lying neurons. In cats with self-control, interneuronal interactions appeared in a significantly larger proportion of cases than in impulsive cats. In combinations resulting in long-latency reactions, cats with self-controlled and impulsive behavior showed no significant difference in the occurrence frequency of interneuronal interactions. The numbers of interneuronal interactions were greater during erroneous responses as compared with correctly performed reactions in animals of the different groups. These data indicate a key role for the interrelated activity of nucleus accumbens neurons in organizing the pattern of long-latency responses typical of selfcontrolled behavior.Neuroscience and Behavioral Physiology 04/2012; 39(4):387-394.
Article: Cooperative Activity of Neurons in the Nucleus Accumbens and Frontal Cortex in Cats Trained to Select Reinforcements of Different Value[show abstract] [hide abstract]
ABSTRACT: Results obtained at the level of the organization of interneuronal interactions of cells in the nucleus accumbens and frontal cortex revealed the features of the involvement of this component in “impulsive” and “self-controlled” behavior, consisting of an increase in bidirectional interactions between the structures of interest, accompanied by simultaneous reductions in the regularity of interactions with increases in “impulsivity” and decreases in “self-control.” Long-latency reactions appearing only in “impulsive” animals were associated with decreases in the control of frontal cortex cells by the nucleus accumbens during the signal period, which correlated with the low activity of the network activity of the nucleus accumbens in these animals. Comparison of the patterns of frontal-accumbens interactions as the animals performed a single type of activity demonstrated that the connections in neuron pairs during the presignal and signal periods were similar, while significant differences in patterns were seen during the performance of different types of activity.Neuroscience and Behavioral Physiology 04/2012; 39(8):741-747.