ABSTRACT: The location of nitroblue tetrazolium-reducing activity was studied in colonic biopsy specimens from 28 patients with ulcerative colitis and from 23 controls. Nitroblue tetrazolium was reduced by epithelial cells, vascular endothelium, and interstitial mononuclear cells of the colonic mucosa from both groups. Blue formazan, a reduced form of nitroblue tetrazolium, was seen faintly after 30 min of culture; the amount increased up to 2 hr tested. The vascular endothelium of the patients with ulcerative colitis reduced nitrobule tetrazolium significantly more than that of the controls. The reduction of nitroblue tetrazolium was graded from 0 to 3 and was 1.00.6 in the controls, 1.60.8 in ulcerative colitis patients (PP
Digestive Diseases and Sciences 02/1993; 38(3):546-550. · 2.12 Impact Factor
ABSTRACT: The complement inhibitor K-76 (Otsuka Pharmaceutical Co., Osaka, Japan) was clinically evaluated as a new drug for treatment of active stage ulcerative colitis (UC). As monotherapy, K-76 proved effective in four of five cases. Furthermore, in patients with active stage UC that continued despite administration of corticosteroid hormone and salicylazosulphapyridine (so-called refractory UC), concomitant administration of K-76 was effective in seven of 21 cases. Thus, we believe that the multifunctional agent K-76 will provide clinicians with a new therapeutic approach to inflammatory bowel diseases, including UC and Crohn's disease.
Diseases of the Colon & Rectum 01/1992; 35(6):560-567. · 3.13 Impact Factor
ABSTRACT: Although the colonofiberscope has undergone various modifications and improvements, the insertion principle remains unchanged;
that is pushing and rotation and the elasticity of the scope itself are inevitable. It often is difficult to maintain proper
balance among these dynamic factors; imbalance prevents deep insertion. Over-elongation of the scope leads to insertion failure,
particularly if there are adhesions of the sigmoid colon, overextension of the colon, or transverse colon ptosis. Our “leading
cord” method is an excellent aid to colonofiberscopy. It can be inserted from the clamp hole of a conventional fiberscope
and hardened to straighten the scope, thereby permitting deep insertion. With this technique the region from the rectum to
the descending colon, as well as a ptosed transverse colon, can be straightened. Our clinical experience indicates that the
rate of successful insertions in colonofiberscopy will be increased considerably with this complementary device.
Diseases of the Colon & Rectum 11/1986; 29(12):882-884. · 3.13 Impact Factor
Journal of Gastroenterology 09/1979; 14(5):450-452. · 4.16 Impact Factor