Publications (1)1.53 Total impact
-
Article: Synthesis and anticancer activity of some 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines
[show abstract] [hide abstract]
ABSTRACT: AbstractThe deregulation of cell cycle components in cancer cells has provided a rationale for the development of small molecule inhibitors of cyclin-dependent kinases as novel anticancer drugs. A series of 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines was synthesized and their kinase inhibitory activity and cytotoxicity against several cancer cell lines has been evaluated. Some of the compounds of the series exhibited induction of caspase-dependent cell death and inhibition of cyclin-dependent kinase 2 (CDK2). Graphical abstract KeywordsPyrazolo[4,3-e][1,2,4]triazine-Anticancer-Cyclin-dependent kinase-Inhibitor-Caspase-ApoptosisMonatshefte fuer Chemie/Chemical Monthly 04/2012; 141(6):709-714. · 1.53 Impact Factor
Top co-authors
Top Journals
Institutions
-
2012
-
Palacký University of Olomouc
Olomouc, Olomoucky kraj, Czech Republic
-
