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ABSTRACT: Cholinesterase inhibitors (ChEIs) are widely used for the symptomatic treatment of Alzheimer’s disease (AD). In vitro and
in animal studies, ChEIs have been shown to influence the processing of Aβ and the phosphorylation of tau, proteins that are
the principal constituents of the plaques and neurofibrillary tangles, respectively, in AD brain. However, little is known
about the effects of these drugs on Aβ and tau pathology in AD. Using avidin-biotin immunohistochemistry and computer-assisted
image analysis, we compared Aβ and tau loads in the frontal and temporal cortices of 72 brains from matched cohorts of AD
patients who had or had not received ChEIs. Patients treated with ChEIs had accumulated significantly more phospho-tau in
their cerebral cortex than had untreated patients (P=0.004). Aβ accumulation was reduced but not significantly. These data raise the possibility that increased tau phosphorylation
may influence long-term clinical responsiveness to ChEIs.
Journal of Neurology 04/2012; 256(5):717-720. · 3.47 Impact Factor
