[show abstract]
[hide abstract]
ABSTRACT: Depression and Genetic variation in serotonin and monoamine transmission have both been associated with body mass index (BMI),
but their interaction effects are not well understood. We examined the interaction between depressive symptoms and functional
polymorphisms of serotonin transporter (SLC6A4) and monoamine oxidase A (MAOA) on categories of BMI. Participants were from
the National Longitudinal Study of Adolescent Health. Multiple logistic regression was used to investigate interactions between
candidate genes and depression on risk of obesity (BMI≥30) or overweight+obese combined (BMI≥25). Males with an MAOA
active allele with high depressive symptoms were at decreased risk of obesity (OR 0.22; 95% CI 0.06–0.78) and overweight+obesity
(OR 0.48; 95% CI 0.26–0.89). No similar effect was observed among females. These findings highlight that the obesity–depression
relationship may vary as a function of gender and genetic polymorphism, and suggest the need for further study.
Behavior Genetics 04/2012; 39(3):296-305. · 2.52 Impact Factor
