Lei Zhang

Harbin University, Charbin, Heilongjiang Sheng, China

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Publications (885)1534.19 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Polyaniline (PANI) microtubes are becoming greatly significant electrochemical materials owing to their large geometric surface area, high conductivity and ideal electrocatalytic activity. In this work, glucose oxidase (GOx) used as a model redox protein, a direct electron transfer strategy based on PANI microtubes was developed for fabricating sensitive biosensors. There is a strong electrostatic interaction between the positive charged PANI microtubes and negative charged GOx, which promotes the immobilization of GOx on the PANI microtubes surface. The immobilized GOx displayed a pair of well-defined quasi-reversible redox peaks with a potential of −0.39 V (vs.SCE) and an ideal electron transfer rate constant (ks) of 3.0 s−1 in PBS solution (0.1 M, pH = 5.5) on the PANI microtubes instead of bare glass carbon electrode (GCE). The amperometric response of GOx/PANI microtubes modified electrode was linearly proportional to the concentration of glucose in the range of 4.0 μM to 0.80 mM. The glucose detection limit was 0.8 μM at signal-to-noise ratio of 3, which was better than reported GOx/PANI film (1 mM), GOx/PANI nanowire (50 μM). The advantages might be attributed to the PANI microtubes’ large geometric surface for carrying enzyme (GOx), efficient electrocatalytic activity to facilitate direct electron transfer of GOx, as well as efficient GOx biocatalyst reaction on the microtubes surface. A promising application of PANI microtubes-based biosensor was offered.
    J. Mater. Chem. B. 12/2014;
  • ChemInform 12/2014; 45(48).
  • Lei Zhang, Wenling Wu
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    ABSTRACT: This paper studies the differential analysis of extended generalized Feistel networks (EGFN). First we construct a class of differential characteristics which conflict with designers' evaluation of minimal number of active S-boxes for EGFN. Then by analyzing the difference cancellation property of EGFN, we propose a method to search a special type of differential characteristics with high probability. We obtain the best case of this kind of differential characteristic for EGFN with block number 4≤k≤324≤k≤32. Our results show that for EGFN with k≥8k≥8 there always exist high probability iterative differential characteristics and their number of active S-boxes for 20-round all equal to 26. Therefore, the actual ability of EGFN resisting differential analysis may be a lot weaker than evaluated by designers and larger block size can not improve the situation.
    Information Processing Letters 12/2014; · 0.49 Impact Factor
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    ABSTRACT: Abstract The essence of the reprogramming activity of somatic cell nuclear transfer (SCNT) embryos is to produce normal fertilized embryos. However, reprogramming of somatic cells is not as efficient as the reprogramming of sperm. In this report, we describe the effect of an inducible, specific miR-34 microRNA expression in donor cells that enables a similar level of sperm:transgene expression on the early development of SCNT embryos. Our results showed that donor cells with doxycycline (dox)-induced miR-34c expression for the preparation of SCNT embryos resulted in altered developmental rates, histone modification (H3K9ac and H3K4me3), and extent of apoptosis. The cleavage rate and blastocyst formation of the induced nuclear transfer (NT) group were significantly increased. The immunofluorescence signal of H3K9ac in embryos in the induced NT group significantly increased in two-cell- and eight-cell-stage embryos; that of H3K4me3 increased significantly in eight-cell-stage embryos. Although significant differences in staining signals of apoptosis were not detected between groups, lower apoptosis levels were observed in the induced NT group. In conclusion, miR-34c expression induced by dox treatment enhances the developmental potential of SCNT embryos, modifies the epigenetic status, and changes blastocyst quality.
    Cellular Reprogramming 12/2014; 16(6):418-27. · 2.29 Impact Factor
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    ABSTRACT: Abiotic stress caused by insecticide treatment is an interesting and challenging topic in plant research. Here a simultaneous extraction method with methyl tert-butyl ether for metabolomics and lipidomics analysis by using rapid resolution liquid chromatography quadrupole time-of-flight mass spectrometry was developed and validated. The extraction efficiency of lipidome and metabolome based on the current developed method showed an obvious improvement compared with literatures. About 300 metabolites were identified in rice leaf. Method validation was performed and analytical properties including the linearity (R2, 0.991–1.000), repeatability (over 87 % peaks with CV cry1Ac and sck genes and its wild counterpart. Antioxidants including ferulic acid and sinapic acid were down-regulated at 24 h after insecticide treatment. Signaling metabolites including salicylic acid and nicotinamide adenine dinucleotide were significantly up-regulated at 12–24 h after treatment in transgenic rice. More flavonoids were significantly changed in transgenic plants. Results indicated that gene transformation affected the metabolic response of rice to insecticide stress.
    Metabolomics 12/2014; 10(6). · 4.43 Impact Factor
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    ABSTRACT: Long noncoding RNAs (lncRNAs) are being increasingly recognized as major players in governing fundamental biological processes through diverse mechanisms. Maternally expressed gene 3 (MEG3) is an imprinted gene located at 14q32 that encodes a lncRNA correlated with several human cancers. Recently, the methylation-dependent downregulation of MEG3 has been described in liver cancers. However, its biological functional role in liver fibrosis remain unknown. In our study, MEG3 levels were remarkably decreased in CCl4-induced mouse liver fibrosis models and human fibrotic livers as demonstrated by real-time quantitative PCR. Moreover, the expression of MEG3 was downregulated in human hepatic stellate cell lines LX-2 cells in response to transforming growth factor-β1 (TGF-β1) stimulation in dose and time-dependent manner. Enforced expression of MEG3 in LX-2 cells inhibited TGF-β1-induced cell proliferation, while promoting cell apoptosis. In addition, hypermethylation of MEG3 promoter was identified by methylation-specific PCR and MEG3 expression was robustly increased by inhibition of methylation with either 5-aza-2-deoxycytidine (5-azadC), or siRNA to DNA Methyltransferase 1 (DNMT1) in TGF-β1-induced LX-2 cells. More importantly, overexpression of MEG3 could activate p53 and mediate cytochrome c release, subsequently leading to caspase-3-dependent apoptosis in TGF-β1-treated LX-2 cells. These findings suggested that MEG3 may play an important role in stellate cells activation and liver fibrosis progression and act as a novel potential therapeutic target for liver fibrosis.
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 11/2014; · 4.91 Impact Factor
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    ABSTRACT: High-surface-area and well-ordered mesoporous Fe-incorporated SBA-15 (xFe-SBA-15) and SBA-15-supported FeOx (yFeOx /SBA-15) with the Fe surface density between 0.09 to 1.11 Fe-atom/nm2 have been prepared using the one-step synthesis and incipient wetness impregnation methods, respectively. Physicochemical properties of these materials were characterized by means of numerous techniques, and their catalytic activities for the combustion of toluene were evaluated. It is found that the xFe-SBA-15 and yFeOx /SBA-15 samples possessed rod- or chain-like morphologies. The Fe species were of high dispersion when the Fe surface density was lower than 0.76 Fe-atom/nm2 in xFe-SBA-15 and 0.64 Fe-atom/nm2 in yFeOx /SBA-15. At a similar Fe surface density and space velocity, the xFe-SBA-15 catalysts showed better activity than the yFeOx /SBA-15 catalysts, in which the xFe-SBA-15 catalyst with Fe surface density 0.59 Fe-atom/nm2 performed the best. It is concluded that the good performance of the xFe-SBA-15 sample with Fe surface density 0.59 Fe-atom/nm2 was associated with its large surface area, high Fe species dispersion, and good low-temperature reducibility.
    Chinese Science Bulletin 11/2014; 59(31). · 1.37 Impact Factor
  • ChemInform 10/2014; 45(43).
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    ABSTRACT: Objectives: S100 calcium binding protein A12 (S100A12) has been supposed to be a pro-inflammatory factor associated with non-infectious inflammatory diseases. However, whether S100A12 is involved in the inflammatory process of primary biliary cirrhosis (PBC) has not been shown. Methods: The levels of S100A12 mRNA transcripts in peripheral mononuclear blood cells (PBMCs) of 66 Chinese patients with primary biliary cirrhosis (PBC), 62 healthy controls (HC) and 55 chronic hepatitis B (CHB) were measured by qRT-PCR. S100A12 serum concentrations in 34 PBC patients were measured by ELISA. Results: The levels of S100A12 mRNA transcripts in PBMCs of patients with PBC were significantly higher than healthy controls (p < 0.01) and that of patients with CHB (p < 0.01). Importantly, the levels of S100A12 mRNA in PBMCs and S100A12 protein levels in serum were positively correlated with biochemical indicators of bile duct and hepatocyte damage. Conclusion: S100A12 might participate in the damage of biliary epithelial cells and hepatocytes in PBC, and analysis of S100A12 expression could be useful as a surrogate marker for the evaluation of PBC activity.
    Immunological investigations. 10/2014;
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    ABSTRACT: SUMMARYmicroRNAs (miRNAs) are small non-coding RNAs that participates in the regulation of many physiological pathways, but a role for spermatozoon-delivered miRNAs in fertilization and embryonic development remains controversial. A library of miRNAs in bovine sperm was constructed using Illumina high-throughput sequencing technology, along with the predication and the pathway analysis of target genes. miRNAs in mammalian spermatozoon were systematically investigated, and a protocol for RNA isolation from the cauda region of an epididymal biopsy was established. Unique sequences that were 18–26 nucleotides in length were mapped to specific precursors in miRBase 20.0 using BLAST. A total of 951 known miRNAs and 8 novel, highly expressed miRNA candidates were identified. The search for endogenous sperm miRNAs will contribute to a preliminary database for functional and molecular mechanistic studies in embryonic development and sperm epigenetic programming. Mol. Reprod. Dev. 2014. © 2014 Wiley Periodicals, Inc.
    Molecular Reproduction and Development 10/2014; · 2.81 Impact Factor
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    ABSTRACT: CD200/CD200R1 signalling has an immunoregulatory effect on the activation threshold of the inflammatory immune response and maintains immune homeostasis. In this study we evaluated the status of CD200/CD200R1 interaction in patients with RA.
    Rheumatology (Oxford, England) 09/2014; · 4.24 Impact Factor
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    ABSTRACT: Activation of glucocorticoid receptor signaling in the stress response to traumatic events has been implicated in the pathogenesis of stress-associated psychiatric disorders such as post-traumatic stress disorder (PTSD). Elevated startle response and hyperarousal are hallmarks of PTSD, and are generally considered to evince fear (DSM V). To further examine the efficacy of corticosterone in treating hyperarousal and elevated fear, the present study utilized a learned helplessness stress model in which rats are restrained and subjected to tail shock for three days. These stressed rats develop a delayed long-lasting exaggeration of the acoustic startle response (ASR) and retarded body weight growth, similar to symptoms of PTSD patients (Myers et al., 2005; Speed et al., 1989). We demonstrate that both pre-stress and post-stress administration of corticosterone (3 mg/kg/day) mitigates a subsequent exaggeration of the ASR measured 14 days after cessation of the stress protocol. Furthermore, the mitigating efficacy of pre-stress administration of corticosterone (3 mg/kg/day for three days) appeared to last significantly longer, up to 21 days after the cessation of the stress protocol, in comparison to that of post-stress administration of corticosterone. However, pre-stress administration of corticosterone at 0.3 mg/kg/day for three days did not mitigate stress-induced exaggeration of the ASR measured at both 14 and 21 days after the cessation of the stress protocol. In addition, pre-stress administration of corticosterone (3 mg/kg/day for three days) mitigates the retardation of body weight growth otherwise resulting from the stress protocol. Congruently, co-administration of the corticosterone antagonist RU486 (40 mg/kg/day for three days) with corticosterone (3 mg/kg/day) prior to stress diminished the mitigating efficacy of the exogenous corticosterone on exaggerated ASR and stress-retarded body weight. The relative efficacy of pre versus post administration of corticosterone and high versus low dose of corticosterone on stress-induced exaggeration of innate fear response and stress-retarded body weight growth indicate that exogenous corticosterone administration within an appropriate time window and dosage are efficacious in diminishing traumatic stress induced pathophysiological processes. Clinical implications associated with the efficacy of prophylactic and therapeutic corticosterone therapy for mitigating symptoms of PTSD are discussed, particularly in relation to diminishing hyperarousal and exaggerated innate fear response.
    Journal of psychiatric research. 09/2014;
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    ABSTRACT: Palladium-catalyzed intramolecular addition of C-N and S-N bond to alkynes with the migration of functional groups has been achieved. A wide range of functional groups including acyl, pyruvoyl, amide, and sulfonyl groups can migrate smoothly and be conveniently introduced at the C-3 postion of indoles in our catalytic system. The operational simplicity and broad substrate scope demonstrate the great potential of this method for the synthesis of highly functional indoles.
    Organic letters. 09/2014;
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    ABSTRACT: Two new coordination polymers have been synthesized by the solvothermal reaction of semirigid tripodal carboxylate with imidazolyl-based auxiliary ligands. The luminescent property and UV–Vis absorption in the solid state have been studied.
    Inorganica Chimica Acta 09/2014; 421:380–384. · 1.69 Impact Factor
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    ABSTRACT: The perovskite material Pr0.4Sr0.6Co0.2Fe0.7Nb0.1O3-δ was used as an anode in direct propane fueled solid oxide fuel cells (SOFCs). After exposure of the initial single phase Pr0.4Sr0.6Co0.2Fe0.7Nb0.1O3-δ to a reducing atmosphere at 900 °C, it transformed to a two-phase system with nano-particles of a Co-Fe bimetallic alloy uniformly distributed on a Ruddlesden-Popper ceramic phase. High cell power output and good stability were obtained using propane as the fuel and ambient air as the oxidant. Due to the catalytic effect of the Co-Fe bimetallic alloy in the SOFC operating conditions, macromolecular compounds of polycyclic aromatic hydrocarbons (PAHs) were generated as by-products in the exhaust stream of the anode. This novel anode system successfully demonstrated the co-generation of electricity and high value end use chemicals from direct hydrocarbon fueled SOFC systems.
    Journal of Power Sources 08/2014; 262. · 5.26 Impact Factor
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    ABSTRACT: The effects of Co addition in the Ni-YSZ anode functional layer (AFL) on the structure and electrochemical performance of SOFC are investigated. XRD analyses confirmed that the active metallic phase is a Ni1-xCox alloy under the operation conditions of the SOFC. SEM observations indicate that the grain size of Ni1-xCox increases with the increasing Co content. Thermogravimetric (TG) analyses on the reduction of the Ni1-xCoxO-YSZ powders show that there are two processes: the chemical reaction control process and the diffusion control process. It is found that the reduction peak corresponding to the chemical reaction control process in the DTG curves moves toward lower temperatures with the increasing Co content, suggesting that the catalysis activity of the Ni1-xCox is enhanced by the doping of Co. It is observed that the SOFC shows the best performance at x=0.03, and the corresponding maximum power densities are 445, 651 and 815 mW cm-2 at 700, 750 and 800 oC, respectively. The dependence of the SOFC performance on the Co content can be attributed to the competing results between the decreased three phase boundary (TPB) length in the AFL and the enhanced catalytic activity of the Ni1-xCox phase with the increasing Co content.
    ACS Applied Materials & Interfaces 08/2014; · 5.90 Impact Factor
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    ABSTRACT: The effects of different types of polymers, partially hydrolyzed polyacrylamide (HPAM) and hydrophobically modified polyacrylamide (HMPAM), on dynamic interfacial tensions (IFTs) of surfactant/model oil systems have been investigated by the spinning drop method in this article. Two anionic surfactants, 1,2-dihexyl-4-propylbenzene sulfonate (366), 1,4-dibutyl-2-nonylbenzene sulfonate (494) and an anionic–nonionic surfactant octyl-[ω-alkyloxy-poly(oxyethylene)]yl-benzene sulfonates (828) with high purity were selected as model surfactants. The influences of polymer concentration on IFT were expounded. It was found that the addition of polymer mostly results in increasing IFT because the interfacial molecular arrangement is modified owing to the interaction between polymer and surfactants. For HPAM, the polymer chains will enter the surfactant adsorption layer to form mixed-adsorption layer. Therefore, HPAM shows strong effect on surfactant molecules with large size, such as 366. Conversely, surfactants can interact with the hydrophobic blocks of HMPAM and form mixed micelle-like associations at interface. As a result, HMPAM shows more impact on IFT of 494 due to small steric hindrance for the formation of interfacial associations. This mechanism has been ensured by 828 molecules with two long alkyl chains. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40562.
    Journal of Applied Polymer Science 08/2014; 131(15). · 1.40 Impact Factor
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    ABSTRACT: Tea is one of the most widely consumed beverages in the world for its benefits to daily life and health. To discover the difference and correlation of chemical compositions in the three typical types of tea, a non-targeted metabolomics method was developed. After the optimization of extraction methods, gas chromatography-time-of-flight mass spectrometry and liquid chromatography-quadrupole time-of-flight mass spectrometry were applied for metabolomics analysis, 1,812 and 2,608 features were obtained, respectively. By comparing with the known compounds in public and/or commercial databases, 173 compounds were tentatively identified, and 109 of them were experimentally confirmed by standards. Totally, 33 tea samples including 12, 12 and 9 samples of green, oolong and black tea, respectively, were analyzed by using the above two methods. Multivatiate analysis, Mann-Whitney U test and hierarchical cluster analysis were used to find and visualize the differential components in the three types of tea. Finally, 90 compounds, which contain catechins, amino acids, organic acids, flavonol glycosides, alkaloids, carbohydrates, lipids, etc, were found with a significant difference among them. This study demonstrates the potentials and power of metabolomics methods to understand the chemical secrets of tea. This should help a lot to optimize the processes of agriculture, storage, preparation and consumption.
    08/2014; 32(8):804-16.

Publication Stats

8k Citations
1,534.19 Total Impact Points

Institutions

  • 2014
    • Harbin University
      Charbin, Heilongjiang Sheng, China
  • 2013–2014
    • Sichuan University
      • Key Laboratory of Green Chemistry and Technology
      Hua-yang, Sichuan, China
    • Peking Union Medical College Hospital
      • Department of Rheumatology
      Beijing, Beijing Shi, China
    • Cea Leti
      Grenoble, Rhône-Alpes, France
  • 2012–2014
    • Fudan University
      • Institutes of Biomedical Sciences
      Shanghai, Shanghai Shi, China
    • University of South Carolina
      • Department of Mechanical Engineering
      Columbia, South Carolina, United States
    • Chongqing Municipal Academy of Chinese Materia Medica
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Civil Aviation University of China
      T’ien-ching-shih, Tianjin Shi, China
    • Peking University
      • School of Electronics Engineering and Computer Science
      Peping, Beijing, China
    • Zhongshan Entry-Exit Inspection and Quarantine Bureau
      中山, Guangdong, China
  • 2009–2014
    • Anhui Science and Technology University
      Pang-pu, Anhui Sheng, China
    • National Yang Ming University
      • Department of Psychiatry
      T’ai-pei, Taipei, Taiwan
    • PLA University of Science and Technology
      Peping, Beijing, China
    • Dalian Polytechnic University
      Lü-ta-shih, Liaoning, China
    • Northwest A & F University
      • College of Veterinary Medicine
      Yangling, Shaanxi Sheng, China
    • China University of Mining Technology
      Wu-hsien, Jiangsu Sheng, China
    • Hunan University
      Ch’ang-sha-shih, Hunan, China
    • Ocean University of China
      • College of Marine Life Science
      Tsingtao, Shandong Sheng, China
    • Shenyang Pharmaceutical University
      Feng-t’ien, Liaoning, China
  • 2008–2014
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
    • Uniformed Services University of the Health Sciences
      • Department of Psychiatry
      Maryland, United States
    • General Hospital of the Air Force, PLA
      Peping, Beijing, China
    • Hangzhou Normal University
      • College of Life and Environmental Sciences
      Hang-hsien, Zhejiang Sheng, China
    • University of Washington Seattle
      • Department of Biochemistry
      Seattle, WA, United States
  • 2007–2014
    • Anhui Medical University
      • Department of Pharmacology
      Luchow, Anhui Sheng, China
    • Beijing University of Technology
      Peping, Beijing, China
    • Chinese PLA General Hospital (301 Hospital)
      Peping, Beijing, China
    • Beijing FivePlus Molecular Medicine Institute
      Peping, Beijing, China
  • 2005–2014
    • University of Science and Technology of China
      • • Department of Materials Science and Engineering
      • • Department of Electronic Engineering and Information Science
      Luchow, Anhui Sheng, China
    • East China JiaoTong University
      Jiangxi, Gansu Sheng, China
    • Nanyang Technological University
      • School of Computer Engineering
      Tumasik, Singapore
  • 2004–2014
    • Chinese Academy of Sciences
      • • State Key Laboratory of Drug Research
      • • State Key Laboratory of Catalysis
      • • Key Laboratory of Computer System and Architecture
      • • State Key Laboratory of Information Security
      • • Institute of Oceanology
      Peping, Beijing, China
    • Fourth Military Medical University
      • Department of Epidemiology
      Xi’an, Liaoning, China
  • 2002–2014
    • The Hong Kong Polytechnic University
      • • Department of Land Surveying and Geo-Informatics
      • • Department of Computing
      • • Biometrics Research Centre
      Hong Kong, Hong Kong
  • 2012–2013
    • Tianjin Eye Hospital
      T’ien-ching-shih, Tianjin Shi, China
  • 2010–2013
    • Changhai Hospital, Shanghai
      Shanghai, Shanghai Shi, China
    • North China Electric Power University
      • Department of Mathematics and Physics
      Peping, Beijing, China
    • Ningbo University
      Ning-po, Zhejiang Sheng, China
    • Northwestern Polytechnic University
      China, Maine, United States
    • University of California, Los Angeles
      Los Angeles, California, United States
  • 2009–2013
    • Dalian Institute of Chemical Physics
      Lü-ta-shih, Liaoning, China
    • China Pharmaceutical University
      • • Department of Pharmaceutics
      • • Division of Medicinal Chemistry
      Nanjing, Jiangxi Sheng, China
    • Tongji Hospital
      Wu-han-shih, Hubei, China
    • Beijing University of Aeronautics and Astronautics (Beihang University)
      • Department of Physics
      Beijing, Beijing Shi, China
  • 2007–2013
    • Hefei University of Technology
      • School of Biotechnology and Food Engineering
      Luchow, Anhui Sheng, China
  • 2006–2013
    • Wuhan University
      • • Department of Neurology
      • • College of Chemistry and Molecular Sciences
      Wuhan, Hubei, China
    • China Agricultural University
      • State Key Laboratory for Agrobiotechnology
      Beijing, Beijing Shi, China
    • State University of New York
      New York City, New York, United States
  • 2005–2013
    • Zhejiang University
      • • College of Pharmaceutical Sciences
      • • Department of Environmental Engineering
      • • School of Medicine
      Hangzhou, Zhejiang Sheng, China
    • Northeast Institute of Geography and Agroecology
      • • State Key Laboratory of Drug Research
      • • Institute of Oceanology
      • • State Key Laboratory of Catalysis
      Beijing, Beijing Shi, China
  • 2004–2013
    • Shanghai Jiao Tong University
      • • State Key Laboratory of Mechanical Systems and Vibration
      • • Department of Computer Science and Engineering
      • • Institute of Image Communication and Information Processing
      • • Institute of Robotics
      Shanghai, Shanghai Shi, China
  • 2011–2012
    • Harbin Institute of Technology
      • Research Center of Biocomputing
      Charbin, Heilongjiang Sheng, China
    • Hefei Institute of Physical Sciences, Chinese Academy of Sciences
      Luchow, Anhui Sheng, China
    • Heilongjiang University of Chinese Medicine
      Charbin, Heilongjiang Sheng, China
    • Xi'an Jiaotong University
      • Institute of Image Processing and Pattern Recognition
      Ch’ang-an, Shaanxi, China
    • Hewlett-Packard
      Palo Alto, California, United States
    • Texas Tech University Health Sciences Center
      • Department of Psychiatry
      Lubbock, TX, United States
  • 2009–2012
    • Shanghai Institutes for Biological Sciences
      Shanghai, Shanghai Shi, China
  • 2010–2011
    • Wayne State University
      • Department of Electrical and Computer Engineering
      Detroit, Michigan, United States
  • 2009–2011
    • Xidian University
      • School of Telecommunications Engineering
      Ch’ang-an, Shaanxi, China
    • University of Illinois at Chicago
      • Department of Computer Science
      Chicago, Illinois, United States
  • 2002–2011
    • The University of Hong Kong
      Hong Kong, Hong Kong
  • 2007–2010
    • IBM
      Armonk, New York, United States
  • 2000–2010
    • Tsinghua University
      • Graduate School at Shenzhen
      Peping, Beijing, China
  • 2008–2009
    • Hong Kong Baptist University
      • Department of Chemistry
      Chiu-lung, Kowloon City, Hong Kong
  • 2007–2009
    • Case Western Reserve University
      • Department of Electrical Engineering and Computer Science
      Cleveland, OH, United States
  • 2004–2009
    • Northwestern Polytechnical University
      • School of Automation
      Xi’an, Liaoning, China
  • 2005–2007
    • Huazhong University of Science and Technology
      • Department of Biliary-Pancreatic Surgery
      Wu-han-shih, Hubei, China
  • 2003–2007
    • The Chinese University of Hong Kong
      • Department of Information Engineering
      Hong Kong, Hong Kong
    • 307 Hospital of the Chinese People's Liberation Army
      Peping, Beijing, China
    • The University of Western Ontario
      • Department of Computer Science
      London, Ontario, Canada
    • University of Illinois, Urbana-Champaign
      • Department of Computer Science
      Urbana, Illinois, United States
  • 2004–2006
    • Shanghai University
      • School of Computer Engineering and Sciences
      Shanghai, Shanghai Shi, China
    • Stony Brook University
      • Department of Computer Science
      Stony Brook, New York, United States
  • 2003–2006
    • McMaster University
      • Department of Electrical and Computer Engineering
      Hamilton, Ontario, Canada