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Publications (18)8.69 Total impact

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    ABSTRACT: Glomus tumor is a neuro-myo-arterial benign hamartoma. It is a relatively uncommon lesion. The aim of this study is to define all the unusual localizations of glomus tumor. From January 1999 to December 2006, we included in this retrospective study all patients who had the classic triad of symptoms with histological exam. We analysed epidemiological, clinical and therapeutical features of our patients. Fourteen patients were found to have histopathologically-proven glomus tumors. The patients, eight men and six women, had mean of age around 42 years. Three unusual locations were found: forearm, sacred region and parasternal. Most glomus tumors occur in the toes and fingertips. They are difficult to diagnose, despite painful symptom, because of their unusual locations. Glomus tumors are rare vascular tumors. The usual presentation is a solitary nodule in the distal portion of a digit, but can also occur wherever, with localizations unaccustomed and disconcerting.
    Annales de chirurgie plastique et esthetique 11/2008; 54(1):51-6. · 0.33 Impact Factor
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    ABSTRACT: Nora's tumour is an uncommon benign tumour, involving mostly tubular bones of hands and feet, and characterized by a proliferation of chondroid, bony and fibrous tissues. Main differential diagnoses are osteochondroma, chondrosarcoma, and osteosarcoma. The authors report a case involving the left foot. The diagnosis was suspected by imaging characteristic features and was confirmed by histological examination. Treatment was surgical, with complete excision. There are no clinical or radiological signs of recurrence on further review one year postoperatively.
    Acta orthopaedica Belgica 09/2008; 74(4):562-5. · 0.63 Impact Factor
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    ABSTRACT: Lymphangioleiomyomatosis (LAM) is a rare condition usually occurring in young women of childbearing age. It is characterised by the presence of abnormal smooth muscle cells (LAM cells) in the lungs, lymph nodes, and/or other organs, with a few reports of isolated extrapulmonary cases. We report the case of a 26-yr-old female who presented with a painless shoulder mass. Ultrasonography, computed tomography and magnetic resonance imaging revealed an intermuscular mass with cystic and solid tissue components, measuring 6 cm x 4 cm. The mass was removed surgically after the diagnosis of LAM was made following tru-cut biopsy. This case corresponds to an exceptional localisation of LAM.
    Acta orthopaedica Belgica 03/2008; 74(1):114-7. · 0.63 Impact Factor
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    ABSTRACT: In order to illustrate the clinical and histological presentations of laryngeal atypical carcinoids and their potential course, we report six cases. We evaluated the factors predictive of local recurrence and metastatic diffusion. For each case, we noted the mitotic index, the quality of the resection, the limits of the tumor and the presence of necrosis. An immunohistochemical study was carried out with a series of antibodies (cytokeratins; D(2)40; CD31; MIB1; P53; P16; TTF1...). The clinical presentation we observed was quite similar to that reported in the literature. These tumors are CK7+, CK8+, CK19+, CK5-6-, CK14- and CK20-. P16 is constantly positive. Only the mitotic index and the lymphatic presence of embolus were correlated with the time course. The tumor is more aggressive when the mitotic index is high and an unfavorable course is observed when there are lymphatic emboli or when the Ki67 index is higher than 5%.
    Annales de Pathologie 03/2008; 28(1):2-8. · 0.24 Impact Factor
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    ABSTRACT: Gastrointestinal stromal tumors (GIST) are rare mesenchymal neoplasms of the gastrointestinal tract that arise from Cajal cells. They are characterized by the expression of a growth factor receptor with tyrosine kinase activity termed c-kit. Use of c-kit enabled the histological characterization of these tumors, the development of a specific treatment which radically transformed the prognosis of this illness, and the accentuation of the role of radiology for these tumors. We report an illustrated observation of duodenal GIST which presented as an abdominal mass with fever.
    Feuillets De Radiologie - FEUILL RADIOL. 01/2008; 48(1):39-44.
  • Journal of Neuroradiology 01/2008; 34(5):345-6. · 1.24 Impact Factor
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    ABSTRACT: In order to illustrate the clinical and histological presentations of laryngeal atypical carcinoids and their potential course, we report six cases. We evaluated the factors predictive of local recurrence and metastatic diffusion. For each case, we noted the mitotic index, the quality of the resection, the limits of the tumor and the presence of necrosis. An immunohistochemical study was carried out with a series of antibodies (cytokeratins; D240; CD31; MIB1; P53; P16; TTF1…). The clinical presentation we observed was quite similar to that reported in the literature. These tumors are CK7+, CK8+, CK19+, CK5-6−, CK14− and CK20−. P16 is constantly positive. Only the mitotic index and the lymphatic presence of embolus were correlated with the time course. The tumor is more aggressive when the mitotic index is high and an unfavorable course is observed when there are lymphatic emboli or when the Ki67 index is higher than 5%.
    Annales De Pathologie - ANN PATHOL. 01/2008; 28(1):2-8.
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    ABSTRACT: Blastomycosis is a systemic fungal infection caused by a thermally dimorphic fungus, Blastomyces dermatitidis. The incidence in immunocompromised patients has increased in the last two decades. A 55-year-old man consulted for inflammatory nodules on the forearm. Biopsy of one nodules showed a pseudoepitheliomatous hyperplastic epidermis overlaying a dense agranulomatous inflammatory infiltrate containing free-formed ovoid bodies enclosing giant macrophageous cells. These findings were consistent with blastomycosis. After a month of treatment cutaneous lesions regressed partially but the patient's general status continued to deteriorate with the appearance of an edematous-ascitic syndrome and icterus. Laboratory blood testing demonstrated cholestasia and abdominal ultrasound showed hepatosplenomegaly. Needle liver biopsy revealed giant B-cell lymphomatous infiltration of the hepatic ducts. The patient's condition worsened rapidly and he died five months after diagnosis despite four rounds of chemotherapy. Blastomycosis is rare in Morocco. Primary infection is usually a pneumonic process. Isolated cutaneous infection is possible but uncommon. To our knowledge the association of blastomycosis and intravascular lymphoma has not been previously reported. In immunocompromised patients, clinical findings can be alarming and the outcome can be rapidly fatal.
    Médecine tropicale: revue du Corps de santé colonial 07/2007; 67(3):278-80.
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    ABSTRACT: When ichthyosis occurs in adulthood, it may signify internal disease, especially malignant hemopathy. A 49-year-old man was admitted to hospital with diarrhea, fever, weight loss and abdominal pain. Physical examination showed generalized ichthyosis with palmoplantar hyperkeratosis and multiple inguinal lymph nodes. Laboratory investigations showed severe pancytopenia. Ultrasonography and CT scan demonstrated intraabdominal lymph node enlargement. Osteomedullary biopsy and open abdominal lymph node biopsy revealed an anaplastic large cell lymphoma. The lymph node involvement subsequently became worse and more severe, and the patient's general condition deteriorated. He died before receiving chemotherapy.
    Internal Medicine 02/2007; 46(7):397-9. · 0.97 Impact Factor
  • Internal Medicine - INTERNAL MED. 01/2007; 46(7):397-399.
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    ABSTRACT: Ganglioneuroma is an uncommon benign tumor that arises from the sympathetic nervous system accounting for less than 1% of all soft-tissue neoplasms. We report the case of a 22 year-old man who presented a ganglioneuroma localized in the zygoma. Ganglioneuroma generally develop in the abdomen or thorax soft tissue. The occurrence of ganglioneuroma in the bone is exceptional. To date less than ten cases have been reported, six of which involved the mandible. We discuss the possible causes of tumor development at this site.
    Revue de Stomatologie et de Chirurgie Maxillo-faciale 12/2006; 107(5):370-2. · 0.39 Impact Factor
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    ABSTRACT: IntroductionLe ganglioneurome est une tumeur bénigne rare, se développant à partir des cellules ganglionnaires du système nerveux sympathique. Elle constituerait moins de 1 % de tous les néoplasmes des tissus mous.ObservationNous rapportons une localisation à l’os zygomatique chez un jeune homme de 22 ans, aux antécédents de traumatisme orbitaire dans l’enfance. La tumeur se manifestait par une simple tuméfaction asymptomatique. Le diagnostic a été posé sur l’analyse de la pièce opératoire après ostéotomie modelante.DiscussionLes sites préférentiels du ganglioneurome sont l’abdomen et le thorax, la localisation osseuse est exceptionnelle avec moins de dix cas rapportés dans la littérature, dont six cas mandibulaires. Nous discutons les causes possibles de cette localisation exceptionnelle.IntroductionGanglioneuroma is an uncommon benign tumor that arises from the sympathetic nervous system accounting for less than 1% of all soft-tissue neoplasms.Case reportWe report the case of a 22 year-old man who presented a ganglioneuroma localized in the zygoma.DiscussionGanglioneuroma generally develop in the abdomen or thorax soft tissue. The occurrence of ganglioneuroma in the bone is exceptional. To date less than ten cases have been reported, six of which involved the mandible. We discuss the possible causes of tumor development at this site.
    Revue de Stomatologie et de Chirurgie Maxillo-faciale. 01/2006; 107(5):370-372.
  • Revue Francophone des Laboratoires 01/2005; 2005(377):59-60.
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    ABSTRACT: Granular cell tumors (GCT) are rarely located in the perianal area. Over the past 3 years, a 56 year-old man presented a papule of the right margin of the anus that had progressively increased in size (1.5 cm). Cell proliferation was located in the dermis and strongly expressed the S100 protein. It was covered by a pseudo-epitheliomatous hyperplasia of the overlying epidermis. Forty months after local surgical excision, there was no sign of recurrence. Granular cell tumors are rare and usually benign. When cutaneous or mucosal, the pseudo-epitheliomatous hyperplasia of the overlying epithelium may, on superficial samples, be mistakenly diagnosed as squamous cell carcinomas. Malignant GCT may, histologically, appear identical to a benign GCT and only the appearance of metastases (generally after local recurrence) permits the subsequent diagnosis of malignancy.
    La Presse Médicale 03/2003; 32(5):221-2. · 0.87 Impact Factor
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    ABSTRACT: Nodular fasciitis is a benign neoplastic and reactive proliferation of fibroblasts of soft tissues, which is often mistaken for a sarcoma because of its rapid growth, rich cellularity and mitotic activity. A case is reported that provides the opportunity to discuss the specific clinical and pathological features of nodular fasciitis.
    Pathologie Biologie 01/2002; 49(10):808-11. · 1.67 Impact Factor
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    ABSTRACT: Nodular fasciitis is a benign neoplastic and reactive proliferation of fibroblasts of soft tissues, wich is often mistaken for a sarcoma because of its rapid growth, rich cellularity and mitotic activity. A case is reported that provides the opportunity to discuss the specific clinical and pathological features of nodular fasciitis.
    Pathologie Biologie. 01/2001;
  • Pathologie Biologie 01/2001; 49(10). · 1.67 Impact Factor
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    ABSTRACT: Le lipome intraosseux du calcanéus est une localisation rare de l’affection. Elle peut poser un problème de diagnostic d’une image lacunaire lorsqu’elle est de découverte fortuite à la radiographie simple. Les formes avec effraction corticale sont exceptionnelles. Les auteurs en rapportent un cas et discutent de l’indication chirurgicale dans cette localisation. Intraosseous lipoma of the calcaneus is a rare, benign, primary bone lesion, frequently misdiagnosed as other tumours, especially unicameral bone cysts. We present the case of a 48-year-old member of the armed services who was diagnosed with intraosseous lipoma of the calcaneus and discuss the clinical presentation and treatment choice.
    Médecine et Chirurgie du Pied 23(4):124-126. · 0.06 Impact Factor