ABSTRACT: ObjectiveTo evaluate the clinical significance of platelet (PLT) count in epithelial ovarian cancer, and to investigate the correlation
between thrombocytosis and the incidence of epithelial ovarian cancer.
MethodsWe evaluated 220 epithelial ovarian tumor patients divided into early stage epithelial ovarian cancer group (n = 80), advanced stage epithelial ovarian cancer group (n = 50) and benign ovarian tumor group (n = 90) as controls, who underwent primary surgical treatment. Three groups were evaluated with the relationship between platelet
counts and preoperative and postoperative CA125, histopathology, abdominal edema, residual tumor, and lymph node metastasis.
Epithelial ovarian cancer patients were evaluated whether platelet count was decreased after surgery.
ResultsThe mean platelet counts were (234.55 ± 71.51) × 109/L in the early stage epithelial ovarian cancer group, (308.12 ± 111.95) × 109/L in the advanced stage epithelial ovarian cancer group, and (206.28 ± 52.62) × 109/L in the benign ovarian tumor group, with a significant difference among the 3 groups (P < 0.05). In the early stage epithelial ovarian cancer group, the platelet count was correlated with histopathology. In the
advanced stage epithelial ovarian cancer group, there was a correlation between thrombocytosis and the incidence of that residual
tumor diameter was greater than 2 cm. But there was no relationship between platelet count and histopathology, CA125, abdominal
edema, or lymph node metastasis. In general the platelet count was decreased after surgery.
ConclusionAn increased platelet count is commonly seen in patients with epithelial ovarian cancer, but it usually decreases after surgery.
Patients with thrombocytosis have poor prognosis. Platelet count can be used as a marker for the development and prognosis
of epithelial ovarian cancer.
The Chinese-German Journal of Clinical Oncology 04/2012; 8(4):225-228.