Publications (1)1.89 Total impact
-
Article: Oligosaccharide tagged β-cyclodextrins: synthesis and biological affinity towards Concanavalin A
[show abstract] [hide abstract]
ABSTRACT: An original synthetic route based on multi-glycosylation and selective protection–deprotection steps has been developed which allows a fast access to complex oligomannosides with both α-(1,3),α-(1,6) and α-(1,3),α-(1,4) cores. The later have been linked to modified β-cyclodextrins bearing spacing arms of varying chemical structure and length through peptidic-like coupling, leading to the formation of a range of oligomannosyl cyclodextrin conjugates. Complexation studies with sodium anthraquinone-2-sulfonate (ASANa) and sodium adamantane 1-carboxylate (ACNa) as guest molecules demonstrated that the β-cyclodextrin inclusion properties are preserved. Binding affinity studies using the mannose specific lectin Concanavalin A (Con A) demonstrated the key role of the density and tridimensional structure of the sugar ligand in recognition events.Journal of Inclusion Phenomena 03/2007; 57(1):9-14. · 1.89 Impact Factor
