Publications (1)13.45 Total impact
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Article: Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR.
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ABSTRACT: Together strong: Cooperative binding of organic (see picture, red) and inorganic fragments provides a strategy for the potent inhibition of protein-protein interactions. By targeting specific Lewis basic side chains in peripheral regions of the binding site for coordination to a rhodium(II) center, the affinity of otherwise weak ligands is improved.Angewandte Chemie International Edition 06/2012; 51(29):7217-20. · 13.45 Impact Factor
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2012
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Rice University
- Department of Chemistry
Houston, TX, USA
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