XiaoBin He

Wuhan Institute Of Virology, Wu-han-shih, Hubei, China

Are you XiaoBin He?

Claim your profile

Publications (1)1.37 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The molecular and pathogenic properties of avian influenza virus (A/duck/Hubei/216/1985/H7N8) isolated from Hubei Province of China in 1985 were characterized. The hemagglutinin gene (HA) of Dk/Hb/216/85/H7N8 had the multiple amino acid sequences (-PEIPKGRG-) at the connecting peptide between HA1 and HA2, which is considered to be a distinguishing molecular characteristic of low pathogenicity. The key sites of host markers among the genes (M, NP, NS, PA and PB2) of Dk/Hb/216/85/H7N8 were similar to those of H5N1 viruses. Phylogenetic analysis showed that the genes (M, NS and PB2) of Dk/Hb/216/85/H7N8 clustered closely with those of Gs/Guangdong/1996/H5N1 (Gs/GD/96), implying that three ancient genes of Gs/GD/96-like viruses had been circulating in Central China during the 1980s. In experimental infection, Dk/Hb/216/85/H7N8 was lowly pathogenic to chickens and mice, consistent with the molecular feature of HA gene. Keywordsavian influenza virus-low pathogenicity-H7N8-H5N1
    Chinese Science Bulletin 06/2010; 55(16):1625-1630. DOI:10.1007/s11434-010-3148-x · 1.37 Impact Factor