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ABSTRACT: ObjectiveTo study the expressions of FAK and Pyk2 in human astrocytic tumors and their relationship with angiogenesis.
MethodsThe S-P immunohistochemical method was used to measure the expressions of FAK, Pyk2 and VEGF proteins in 58 human brain astrocytic
tumors, and microvessel density (MVD) was detected by CD31 staining.
ResultsIn astrocytic tumors with I, II, III and IV grades, the positive rates of FAK were 20.00%, 26.67%, 44.44% and 50.00%, respectively,
those of Pyk2 were 40.00%, 60.00%, 77.78% and 85.00%, respectively. FAK and Pyk2 expressions, especially Pyk2, correlated
positively with VEGF expression and MVD.
ConclusionFAK and Pyk2 plays the important role in astrocytic tumor angiogenesis through regulation to VEGF.
The Chinese-German Journal of Clinical Oncology 10/2008; 7(11):658-660.