Publications (2)4.36 Total impact
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Article: Immunohistochemical expression of β-human chorionic gonadotropin in colorectal carcinoma
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ABSTRACT: The presence of human -chorionic gonadotropin (HCG) was immunohistochemically studied in 123 cases of primary colorectal carcinoma using the avidin-biotinperoxidase complex method. Positive staining for HCG was recognized in 45 (36.6%) tumors and a statistical difference was observed between the HCG-positive (n=45) and-negative (n=78) groups concerning the frequency of blood vessel invasion in the primary tumor (PPSurgery Today 11/1996; 26(12):966-970. · 1.22 Impact Factor -
Article: Multiple colorectal neoplasms in a young adult with hypogammaglobulinemia
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ABSTRACT: We report on a 22-year-old man with congenital hypogammaglobulinemia who developed multiple colorectal neoplasms. An immunodeficiency had been diagnosed in the patient since two years of age, and this time many tumors of the sigmoid colon and rectum were detected by barium enema and fiberscopy. Abdominoperineal resection was performed, and the resected specimen revealed 29 polyps, including 9 adenocarcinomas and 20 adenomas. The carcinomas, measuring 0.8 to 11.0 cm in size, showed various depths of invasion, and the adenomas, measuring 0.2 to 1.5 cm in size, showed various degrees of epithelial atypia. DNA analysis demonstrated that the tumors were heterogeneous, showing different DNA index and ploidy patterns. The pathogenetic relation between malignancy and immunodeficiency is also reviewed.Diseases of the Colon & Rectum 01/1992; 35(2):197-200. · 3.13 Impact Factor
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Institutions
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1992–1996
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Kyushu University
Fukuoka-shi, Fukuoka-ken, Japan
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