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Publications (7)1.31 Total impact

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    ABSTRACT: Justification. In many publications on cancer in Africa, the majority of patients were seen in advanced stages (III or IV) during the first consultation. So, it was important to look for factors that explain this situation. Methods. A survey by questionnaire was made in our Medical Oncology Department of University Teaching Hospital of Brazzaville from January to October 2010. The responsibility of advice to go to hospital was codified in Arrival in Advanced Stage (AAS) from the weakest (AAS 1) to the strongest (AAS 8) according to the knowledge in oncology. The impact of organ accessibility and the patient's instruction level were also evaluated. Results. One hundred and ninety-six patients seen in consultation, hospital day and hospitalization were asked and we had gathered the same information in patients' medical files. Our sample was essentially made by women (67,4%). The age of patients were from 21 to 83 years old with average of 53,8. The direct responsibility of the patient was weak (24,4%) by ignorance or fear of diagnosis. The hospital personal, the nurses and physicians who work in private were for a great part: 40,8%. The number of practitioners by category had limited the results because of the difficulty to join them. The medical doctor, specialist or not, were responsible at 25,5%. Conclusion. The medical vulgarization, large information, specialization training adapted were the way to choose in the resolution of the problem, which impact on therapeutic result was undeniable.
    Bulletin du cancer 02/2013; · 0.61 Impact Factor
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    ABSTRACT: The Brazzaville cancer registry was created in 1996 with the support of the International Agency Research against Cancer (IARC) which is located in Lyon, France. The Brazzaville cancer registry is a registry which is based on population which records new cancer cases occurring in Brazzaville by using Canreg 4.0 Software. Its aim is to supply useful information to fight against cancer to physicians and to decision makers. We conducted this study whose target was to determine the incidence of cancer in Brazzaville during twelve years, from January 1st, 1998 to December 31, 2009. During that period 6,048 new cancer cases were recorded: 3,377 women (55.8%), 2,384 men (39.4%), and 287 children (4.8%) from 0 to 14 years old with an annual average of 504 cases. Middle age to the patient's diagnosis was 49.5 years in female sex and 505.5 years old for male sex. The incidence rate of cancers in Brazzaville was 39.8 or 100.000 inhabitants per year and by sex we observed 49 to female sex and 35.2 for male sex. The first cancers localizations observed to women were in order of frequency: breast, cervix uterine, liver ovaries, hematopoietic system, to men : liver, prostate, hematopoietic system, colon and stomach; to children : retina, kidney, hematopoietic system, liver and bones. These rates are the basis to know the burden of cancer among all pathologies of Brazzaville and the achievement of a national cancer control program.
    Bulletin du cancer 02/2013; 100(2):135-139. · 0.61 Impact Factor
  • J. Nsondé Malanda, S. Djabanga, C. Gombé Mbalawa
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    ABSTRACT: Les localisations mammaires primitives des sarcomes sont rares. Aussi, nous avons pensé rapporter ici les caractères propres de cette variété histologique. Nous avons ainsi entrepris une étude rétrospective sur treize années (1996–2008). Elle a concerné des localisations mammaires primitives des sarcomes histologiquement confirmés et suivis dans le service de carcinologie et radiothérapie du CHU de Brazzaville. Au cours de la période d’étude, 999 cancers du sein ont été observés dont quatre, soit 0,4 %, pour sarcome. L’âge moyen était de 32,7 ans et les extrêmes de 19 et 45 ans. Le motif de consultation a été une volumineuse néoformation (18,6 cm en moyenne) avec une circulation collatérale et sans adénopathie. Quatre variétés de sarcomes ont été retrouvées: sarcome à cellules fusiformes, rhabdomyosarcome, histiocytofibrosarcome et hémangiopéricytome malin. L’évolution a été défavorable en moins de dix mois. Malignant breast sarcoma is rarely observed. We report here the types of this histological variety. We conducted a retrospective study for 13 years (1996–2008). It concerned the locations of primary breast sarcomas histologically confirmed and monitored in the radiotherapy and oncology department of the CHU of Brazzaville. During the study period, 999 cases of breast cancer were observed, and 4 (0.4%) of them were for breast sarcoma. The mean age was 32.7 years, with extremes of 19 and 45 years. The consultation motive was a big tumor (18.6 cm on average), with collateral circulation and no lymphadenopathy. Four types of sarcomas were found: spindle cell sarcoma, rhabdomyosarcoma, malignant hemangiopericytoma, and histiocytofibrosarcoma. Outcome was bad despite mastectomy and chemotherapy. Mots clésSarcome–Sein–Primitif–Brazzaville KeywordsSarcoma–Breast–Primary–Brazzaville
    Journal africain du cancer / African Journal of Cancer 01/2011; 3(1):20-23.
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    ABSTRACT: Les mélanomes malins de localisations primitives extracutanées ne sont pas courants. Nous rapportons, ici, cinq observations qui ont été rassemblées après 26 ans et quatre mois d’activité dans le service de médecine et carcinologie (SMC) du CHU de Brazzaville. Ces cinq observations ont concerné des localisations suivantes: col utérin, endomètre, jonction anorectale, langue et palais. La démonstration du caractère primitif après diagnostic positif, l’administration du traitement adéquat et les modalités de surveillance postthérapeutique ont constitué les principaux points d’analyse. Primary malignant non-cutaneous melanomas are rare. We report here five observations collected during 26 years and 4 months of activity in the Medical Oncology Department of Brazzaville University Teaching Hospital. These five observations concerned the followed localisations: cervix, endometrium, high rectum, tongue, and palate. The demonstration of primary character after positive diagnosis, administration of appropriate treatment and conditions of post-therapeutic follow-up were the main points of analysis.
    Journal africain du cancer / African Journal of Cancer 01/2009; 1(1):16-20.
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    ABSTRACT: Les auteurs rapportent un cas de carcinose péritonéale dont la tumeur primitive est prostatique, chez un patient de 81 ans ayant subi une prostatectomie trois ans plutôt. La découverte d’une ascite hémorragique riche en protéine et en cellules adénocarcinomateuses identiques à celles de la tumeur primitive, l’augmentation de l’antigène prostatique spécifique et le résultat de l’histologie de la pièce opératoire, qui montre la présence d’un adénocarcinome, font évoquer une carcinose péritonéale à point de départ prostatique. Cette observation permet de souligner la rareté reconnue à ce type de localisation de métastases de l’adénocarcinome de la prostate. The authors report a case of peritoneal carcinomatosis deriving from a prostatic primary tumour in an 81 year old patient, who had undergone prostatectomy three years earlier. There was haemorrhagic ascites with high protein content. This contained many adenocarcinomatous cells identical to those of the primary tumour. Prostate specific antigen was raised. Histology of the original operative specimen had revealed adenocarcinoma. All of these findings suggested a diagnosis of peritoneal carcinomatosis secondary to a prostatic primary. This case enables us to emphasise the known rarity of this locus for metastases in prostatic adenocarcinoma.
    Journal Africain d?Hépato-Gastroentérologie 01/2009; 3(4):224-225.
  • J. Nsondé Malanda, J. F. Péko, C. Gombé Mbalawa
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    ABSTRACT: Deux cas de sarcome testiculaire ont été observés au CHU de Brazzaville. Le premier patient était âgé de 41 ans, reçu au service de chirurgie polyvalentepourunegrosse bourse douloureuse évoluant depuis trois mois. Il a bénéficié d’une orchidectomie gauche avec curage ganglionnaire. Il a été perdu de vue huit mois plus tard. Le second, âgé de 21 ans, consulte pour une augmentation de volume de son testicule, constatée huit mois avant. Il a subi une orchidectomie totale gauche, et l’examen microscopique de la pièce opératoire a conclu à un sarcome testiculaire à cellules fusiformes. Mais, trois mois après l’acte opératoire, l’évolution a été marquée par une altération de l’état général et l’apparition d’une métastase hépatique et d’une hydroné-phrose unilatérale gauche. Le patient a ensuite été mis sous chimiothérapie (vincristine et cisplatine). Quatre mois après, on a assisté à une rémission complète, traduite par la disparition de la métastase hépatique, et la restauration de l’état général. Cette heureuse situation s’est maintenue jusqu’au 30 juin 2008, soit 28 moisaprès l’acte opératoire. Two cases of testicular sarcoma were encountered in Brazzaville university hospital. The first consisted of a 41-year old man who was admitted in the polyvalent surgeon unit for an enlarged testicle. He underwent left orchiectomy. He did not come back for his regular visit 8 months later. The second patient was a young man of 21 years who was seeking care for an increase of his left testicle seen eight months before. He underwent left orchiectomy and according to the histopathologic evaluation, he had a testicular spindle cells sarcoma. Three months after surgery, the patient showed an alteration of his general state while liver metastases and left hydronephrosis were observed. Chemotherapy with vincristin and cisplatin was initiated. Complete remission was seen after three cycles of chemotherapy, with the disappearance of liver metastases and the restoration of a good general health status until 28 months after surgery in 30 June 2008. Mots clésSarcome–Testicule–Jeune–Rémission compléte KeywordsSarcoma–Testicle–Young–Complete remission
    Oncologie 12:45-47. · 0.10 Impact Factor
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    ABSTRACT: Les tumeurs mésenchymateuses malignes (TMM) sont un groupe d’affections néoplasiques rares, avec une fréquence de 0,86 %. Du 1er janvier 1996 au 31 mai 2008, soit une période de 12 ans et cinq mois, 5 307 nouveaux cas de cancer ont été relevés dans le registre des cancers de Brazzaville (RCB) qui siège dans le service de carcinologie et de radiothérapie du CHU de Brazzaville. Durant cette période, 46 cas de TMM ont été observés, dont 33 cas (0,62 %) étaient localisés aux membres, avec respectivement dix (30,3 %) aux membres supérieurs et 23 (69,7 %) aux membres inférieurs. L’âge moyen a été de 36,6 ans (extrêmes de 15 et 75 ans). Le motif principal de consultation a été la découverte d’une masse tumorale. La taille moyenne de la tumeur était de 13,3 cm, avec des extrêmes de 7 et 24 cm. Le délai moyen de consultation était de 16,5 mois. Les types histologiques les plus fréquents ont été: le sarcome différencié (30,3 %) et le fibrosarcome (30,3 %), suivis du rhabdomyosarcome (18,2 %). L’intérêt de l’immunohistochimie a été évoqué dans la précision du type histologique et dans l’attitude thérapeutique ultérieure. Onze des 33 patients n’ont pas reçu de traitements spécifiques. Après 12 mois, 19 patients étaient décédés, sept patients ont été perdus de vue et sept patients (4,5 %) étaient vivants. Malignant mesenchymatous tumors are uncommon diseases. From 1st January 1996 to 31st May 2008, a period of 12 years and five months, 5307 new cases of cancer were recorded; of these, 33 cases (0.86%) of malignant mesenchymatous tumors, representing 71.72% of all malignant mesenchymatous tumors, were located in the limbs: 10 cases on upper limbs (30.30%) and 23 cases on lower limbs (69.69%). The average age was 36.69 years (range: 15 to 75 years); the mean reason for consultation was the discovery of tumor masses, with an average time before consultation of 16.5 months. The average size of tumor was 13.33 cm (range: 7 to 24 cm). The histological types frequently met were undifferentiated sarcoma (30.3%) and fibrosarcoma (30.3%), rhabdomyosarcoma (18.2%), chondrosarcoma 6.0%, leiomyosarcoma 6%, hemangiopéricytoma 6%, and synovialosarcome (3%). The immunohistochemical test was evocated in the precision of the histological type and the subsequent management of the tumors. Eleven patients did not receive specific treatment. After 12 months, 19 patients had died, seven patients had been lost to follow up, and seven patients were alive. Mots clésTumeurs mésenchymateuses–Membres–Brazzaville KeywordsMalignant mesenchymatous–Limbs–Brazzaville
    Journal africain du cancer / African Journal of Cancer 3(1):44-48.