Elizabeth J. Soilleux

Oxford University Hospitals NHS Trust, Oxford, England, United Kingdom

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Publications (5)3.77 Total impact

  • Zanna J. Voysey, Elizabeth J. Soilleux
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    ABSTRACT: Bone marrow involvement is assessed in lymphoma staging/restaging following treatment/relapse by a combination of an aspirate and trephine biopsy. Of 262 consecutive cases staged by aspirate and trephine, the aspirate yielded a diagnosis when a trephine did not in only 11.8%. Trephine biopsies were positive in 34.7% cases and equivocal/insufficient in 14.9%, while aspirates were positive in 11.1% cases and equivocal/insufficient in 21%. We suggest that in the majority of cases, it may be acceptable either to store an aspirate for reporting only if the trephine is inconclusive or to take a trephine biopsy without an aspirate. KeywordsLymphoma–Bone marrow–Staging–Trephine–Aspirate–Correlation
    01/2011; 4(2):113-116.
  • Elizabeth J. Soilleux
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    ABSTRACT: In recent years, there has been a better appreciation of mast cell and monocyte/macrophage/histiocyte/dendritic cell ontogeny, which has led to reclassification of certain entities within the World Health Organization (WHO) classification of tumours of haematopoietic and lymphoid tissues. Notably, mastocytosis has been reclassified as a chronic myeloproliferative neoplasm, while the former “blastic natural killer cell lymphoma” or “haematodermic neoplasm” is now known as a blastic plasmacytoid dendritic cell neoplasm and classified with the acute leukaemias. This review aims to give a brief overview of the physiological roles and patterns of migration of the corresponding normal cells before discussing the presentation and diagnostic features of mast cell and monocyte/dendritic cell neoplasms. Distinguishing reactive from neoplastic proliferations still poses major challenges and the reasons for this are briefly explained.
    Diagnostic Histopathology 04/2010; 16(4):182-205.
  • Elizabeth J. Soilleux
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    ABSTRACT: The thymus is an anterior mediastinal lymphoid organ important for immunological self-tolerance that comprises epithelial, lymphocytic, histiocytic and stromal elements with characteristic histological arrangements. Its complex embryological development means that dysgenesis and embryological remnants may be seen and rarely lead to sequelae such as tumours. Thymic biopsy or thymectomy may be performed for diagnostic reasons, although thymectomy is more commonly performed as a treatment, usually for myaesthenia gravis or tumours. The major categories of thymic pathology include cysts, hyperplasia, thymomas, haematopoietic neoplasms, primary and secondary carcinomas, neuroendocrine tumours, germ cell tumours and soft tissue tumours.
    Diagnostic Histopathology. 01/2010;
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    ABSTRACT: Improving vaccine immunogenicity remains a major challenge in the fight against developing country diseases like malaria and AIDS. We describe a novel strategy to identify new DNA vaccine adjuvants. We have screened components of the Toll-like receptor signalling pathways for their ability to activate pro-inflammatory target genes in transient transfection assays and assessed in vivo adjuvant activity by expressing the activators from the DNA backbone of vaccines. We find that a robust increase in the immune response necessitates co-expression of two activators. Accordingly, the combination of tak1 and tram elicits synergistic reporter activation in transient transfection assays. In a mouse model this combination, but not the individual molecules, induced approximately twofold increases in CD8+ T-cell immune responses. These results indicate that optimal immunogenicity may require activation of distinct innate immune signalling pathways. Thus this strategy offers a novel route to the discovery of a new generation of adjuvants.
    Vaccine 08/2009; 27(41):5589-98. · 3.77 Impact Factor
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    Elizabeth J. Soilleux, Margaret M. Burke
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    ABSTRACT: Sudden cardiac death (SCD) in younger people is rarely due to ischaemic or hypertensive heart disease, but more commonly is a consequence of congenital heart defects, genetic abnormalities affecting the myocardium and other rare non-ischaemic causes. The potentially hereditary causes include cardiomyopathies, primary arrhythmogenic disorders (e.g. channelopathies) and some storage disorders. Here we describe a pragmatic approach to autopsies that may represent SCD due to a potentially hereditary condition. We consider briefly non-cardiac and cardiac causes of sudden death that should be excluded as part of a detailed autopsy investigation. We discuss the circumstances in which genetic analysis of material preserved at autopsy, followed by family screening, should be undertaken. We then describe the recently instigated UK Cardiac Pathology Network that aims to improve and maintain standards of autopsy investigation and to encourage subsequent genetic analysis of relevant material and family screening, in addition to setting up and maintaining a database of SCD due to these rare potentially hereditary conditions in the UK.
    Diagnostic Histopathology. 01/2009;