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    ABSTRACT: Potentilla chinensis has been widely used as a traditional medicine for the treatment of many diseases. In macrophages, nitric oxide (NO) released as an inflammatory mediator and has been proposed an important modulator of many pathophysiological conditions. In the present study, we investigated the inhibitory effects of methanol extracts of P. chinensis (PCM) on NO production in mouse (C57BL/6) peritoneal macrophages. PCM suppressed IFN-γ and LPS-induced NO production independent of iNOS expression. Interestingly, iNOS enzyme activity was reduced by PCM treatment. On the contrary to iNOS, cyclooxygenase-2 (COX-2) expression was attenuated by PCM significantly. PCM also demonstrated potent radical scavenging activity and reducing power. The present results indicate that PCM’s inhibitory action on the NO production is not due to attenuation of iNOS expression but direct scavenging of NO radical. These results suggest that PCM may be beneficial in diseases which related to oxidative stress-mediated inflammatory disorders such as rheumatoid arthritis. Keywords Potentilla chinensis –Anti-inflammatory–Antioxidant
    Oriental Pharmacy and Experimental Medicine 01/2011; 11(2):137-142.