[Show abstract][Hide abstract] ABSTRACT: Potentilla chinensis has been widely used as a traditional medicine for the treatment of many diseases. In macrophages, nitric oxide (NO) released
as an inflammatory mediator and has been proposed an important modulator of many pathophysiological conditions. In the present
study, we investigated the inhibitory effects of methanol extracts of P. chinensis (PCM) on NO production in mouse (C57BL/6) peritoneal macrophages. PCM suppressed IFN-γ and LPS-induced NO production independent
of iNOS expression. Interestingly, iNOS enzyme activity was reduced by PCM treatment. On the contrary to iNOS, cyclooxygenase-2
(COX-2) expression was attenuated by PCM significantly. PCM also demonstrated potent radical scavenging activity and reducing
power. The present results indicate that PCM’s inhibitory action on the NO production is not due to attenuation of iNOS expression
but direct scavenging of NO radical. These results suggest that PCM may be beneficial in diseases which related to oxidative
stress-mediated inflammatory disorders such as rheumatoid arthritis.
Oriental Pharmacy and Experimental Medicine 01/2011; 11(2):137-142.