Roy Mathew

University of Maryland, College Park, College Park, MD, United States

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Publications (1)1.76 Total impact

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    ABSTRACT: Tyrosine phosphorylation events are key components of several cellular signal transduction pathways. This study describes a novel method for identification of substrates for tyrosine kinases. Co-expression of the tyrosine kinase EphB1 with the intracellular domain of guanylyl cyclase C (GCC) inEscherichia coli cells resulted in tyrosine phosphorylation of GCC, indicating that GCC is a potential substrate for tyrosine kinases. Indeed, GCC expressed in mammalian cells is tyrosine phosphorylated, suggesting that tyrosine phosphorylation may play a role in regulation of GCC signalling. This is the first demonstration of tyrosine phosphorylation of any member of the family of membrane-associated guanylyl cyclases.
    Journal of Biosciences 04/2012; 25(4):339-346. · 1.76 Impact Factor

Publication Stats

5 Citations
1.76 Total Impact Points

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  • 2012
    • University of Maryland, College Park
      • Department of Animal and Avian Sciences
      College Park, MD, United States