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    ABSTRACT: Objective The aim of the study was to estimate the clinical value of serum interleukin-18 (IL-18) and nitric oxide (NO) activities in patients with prostate cancer. Methods The 50 patients with prostate cancer and 25 control subjects were measured in serum IL-18 by enzyme-linked immunosorbent assay (ELISA) and nitrate + nitrite level by an index of NO generation. Results Serum IL-18 and nitrate + nitrite levels were significantly higher in patients with prostate cancer when compared to the control subjects (P < 0.05). Serum IL-18 level was significantly higher in patients with stages B, C and D when compared to patients with stage A (P < 0.05). Serum IL-18 level was significantly higher in the metastatic patients compared with the nonmetastatic patients (P < 0.01). There was no difference in serum nitrate and nitrite level between metastatic and nonmetastatic patients (P > 0.05). The serum IL-18 and nitrate and nitrite levels decreased after patients underwent surgical resection. Conclusion Serum IL-18 level may be a useful marker to predict prognosis of patients with prostate cancer after surgery. Long-term follow- up is required to clarify this hypothesis.
    The Chinese-German Journal of Clinical Oncology 10(12).
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    ABSTRACT: ObjectiveThe aim of our study was to analyze interleukin-18 (IL-18) and vascular endothelial growth factor (VEGF) serum levels in patients with prostate cancer before and after operation and the possible correlation between IL-18 and VEGF serum levels. MethodsSerum IL-18 and VEGF levels were measured by enzyme-linked immunosorbent assay (ELISA) in 36 patients with prostate cancer before and after radical prostatectomy and in 25 healthy controls. ResultsSerum IL-18 and VEGF levels were significantly higher in patients with prostate cancer before operation with respect to healthy controls (P < 0.05), with a highly significant correlation between IL-18 and VEGF (R = 0.800, P = 0.017). It was significantly reduced in IL-18 and VEGF after operation. IL-18 and VEGF serum concentrations were correlated with the clinicalopathological status of patients with prostate cancer. ConclusionIt is correlative with serum IL-18 and VEGF. Serum IL-18 and VEGF levels may be useful prognostic marker in patients with prostate cancer. Key wordsinterleukin-18 (IL-18)-vascular endothelial growth factor (VEGF)-prostate cancer
    The Chinese-German Journal of Clinical Oncology 9(11):643-647.