ABSTRACT: Complex formation between CDs and a very poorly water-soluble antifungal agent, clotrimazole (CLT), was studied. Products containing -CD were prepared in two molecular ratios by four methods. The rates of dissolution ofthe 1 : 1 drug/CD combinations revealed better dissolution properties than thoseof the 1 : 2 products. Drug/CD interactions in both aqueous solution and the solidstate were studied by phase solubility and thermal analysis. The effects of differentauxiliary materials (polymers, hydroxy acids and surfactants) on the aqueous solubilityof CLT were investigated. The aqueous solubility of CLT was increased significantly bythe addition of the auxiliary materials. Particle size distribution, partition coefficient,surface tension, heat of dissolution and wettability studies were also carried out.
Journal of Inclusion Phenomena 01/2003; 46(1):1-13. · 1.89 Impact Factor