Publications (2)0 Total impact
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ABSTRACT: This study was performed to determine the acute effects of a single intravenous dose of ondansetron on the electrocardiogram of dogs. Eight adult crossbreed dogs were used in this study. The electrocardiogram recording was obtained before the infusion of ondansetron and repeated at 5, 30, 60, and 120min after treatment. The ECG measurements of heart rate, PR interval, QRS interval, ST segment, T-wave amplitude, and QT interval were taken from lead II. The JT interval was calculated as the QT interval minus the QRS interval. Rate-corrected QT and JT intervals (QTc and JTc) were obtained by using two formulas QTc = QT/3√R-R interval and JTc = JT/3√R-R interval. In comparison to the baseline values, mean heart rate significantly decreased at 5, 30, and 60min after administration of intravenous ondansetron. There was significant prolongation of QT, QTc, and JT intervals at 30 and 60min after infusion of drug. T-waves showed significant changes in its direction and amplitude at 60 and 120min after treatment compared to the baseline values. In conclusion, ondansetron at standard dosages apparently causes ECG changes in healthy dogs. These include marked QT interval prolongation and reduction in heart rate. Although in current experiment, we did not observe serious arrhythmias in this group of dogs, it does not exclude the possibility of ventricular arrhythmias in prolonged use after reaching a certain cumulative dose. KeywordsOndansetron-Electrocardiogram-DogComparative Clinical Pathology 04/2012; 19(5):499-502.
Article: Successful management of refractory psychomotor seizures with gabapentin and phenobarbital in a Doberman pinscher dog[show abstract] [hide abstract]
ABSTRACT: Gabapentin is a new antiepileptic drug which is used in humans with complex partial epilepsy. Recently, two published studies described the efficacy of gabapentin in dogs with refractory epilepsy. However, clinical application of gabapentin in dogs with refractory psychomotor seizure has not been documented. The present report describes a 2-year-old male Doberman pinscher dog with a history of recurrent bizarre behaviors such as aggression, circling, and flank-biting. Initial oral administration of phenobarbital resulted in resolution of psychomotor seizures, but 3months after the initial presentation, the dog became refractory to the selected treatment. The treatment was changed to a combination therapy with phenobarbital and gabapentin. Two days after starting the combination therapy, the dog became seizure-free, and there were no detectable signs of previous abnormal behaviors during the 14-month follow-up period.Comparative Clinical Pathology 04/2012; 19(1):125-127.