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Publications (2)2.33 Total impact

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    ABSTRACT: The inhibitory effect of edible microalga, Nostochopsis sp. on the activation of hyaluronidase was evaluated. The 50% inhibitory concentration (IC50) of the aqueous extract and the ethanol-insoluble fraction of aqueous extract was 0.0148 and 0.0178 mg/mL, respectively. The IC50 of disodium cromoglycate (DSCG) used as the anti-allergic medicine was 0.120 mg/mL. The IC50 of Nostochopsis sp. was 8 times smaller than that of DSCG. The aqueous extract was ultrafiltered through a membrane having a molecular exclusion limit of 10 kDa. The IC50 of the residue was almost the same as that of aqueous extract. These results suggest that Nostochopsis sp. might have strong anti-allergic substance(s) which may be polysaccharides.
    Algal Resources. 01/2012; 5:17-19.
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    ABSTRACT: The inhibitory effects of seven microalgae, Nostoc flagelliforme, Spirulina platensis, Porphyridium purpureum, Rhodosorus marinus,Chlorella pyrenoidosa, Dunaliella salina and Pleurochrysiscarterae on the activation of hyaluronidase were evaluated. Theinhibitory effect of the ethanol-insoluble fraction of each water extract frommicroalgae was stronger than that of the ethanol-soluble fraction. The50% inhibitory concentration (IC50) of the ethanol-insolublefraction of S. platensis, P. purpureum, R. marinus, C.pyrenoidosa, D. salina and P. carterae was 0.15, 0.18, 0.26,0.94, 0.15 and 0.41 mg mL-1, respectively. The IC50 ofN .flagelliforme was not calculated, because there was no detectableinhibitory effect of this alga. The IC50 of disodium cromoglycate(DSCG) used as the anti-allergic medicine was 0.14 mg mL-1. The IC50 of S. platensis, P. purpureum and D. salinawere almost the same as that of DSCG. This suggests that theethanol-insoluble fraction of S. platensis, P. purpureum and D. salina might be an anti-allergic substance. The ethanol-insoluble fractionof S. platensis and D. salina was ultrafiltered through a membranehaving a molecular exclusion limit of 20 kDa. The IC50 of theresidue was stronger than that of the filtrate. These results suggest that theanti-allergic substance(s) of these microalgae may be polysaccharides.
    Journal of Applied Phycology 11/2001; 13(6):489-492. · 2.33 Impact Factor